公开(公告)号：US06569851B1

公开(公告)日：2003-05-27

申请号：US09338191

申请日：1999-06-22

申请人： Richard C. Thompson ,  Stephen Wilkie ,  Douglas R. Stack ,  Eldon E. VanMeter ,  Qing Shi ,  Thomas C. Britton ,  James E. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  Steven S. Henry ,  Stacey L. McDaniel ,  Russell D. Stucky ,  Warren J. Porter

发明人： Richard C. Thompson ,  Stephen Wilkie ,  Douglas R. Stack ,  Eldon E. VanMeter ,  Qing Shi ,  Thomas C. Britton ,  James E. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  Steven S. Henry ,  Stacey L. McDaniel ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： C07D24324

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D403/12 ,  C07K5/0821 ,  C07K5/0823

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及预防性和治疗性地用这种药物组合物治疗阿尔茨海默病的方法。

公开(公告)号：US06906056B2

公开(公告)日：2005-06-14

申请号：US10392332

申请日：2003-03-20

申请人： Richard C. Thompson ,  Stephen Wilkie ,  Douglas R. Stack ,  Eldon E. Vanmeter ,  Qing Shi ,  Thomas C. Britton ,  James E. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  Steven S. Henry ,  Stacey L. McDaniel ,  Russell D. Stucky ,  Warren J. Porter

发明人： Richard C. Thompson ,  Stephen Wilkie ,  Douglas R. Stack ,  Eldon E. Vanmeter ,  Qing Shi ,  Thomas C. Britton ,  James E. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  Steven S. Henry ,  Stacey L. McDaniel ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61K31/445 ,  A61K31/4706 ,  A61K31/501 ,  A61K31/55 ,  A61K38/00 ,  C07D401/12 ,  C07D403/12 ,  C07K5/097 ,  C07D267/02 ,  A61P25/28 ,  C07D223/12 ,  C07D487/00

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D403/12 ,  C07K5/0821 ,  C07K5/0823

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06559141B2

公开(公告)日：2003-05-06

申请号：US09915564

申请日：2001-07-27

申请人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

发明人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61K3155

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06635632B1

公开(公告)日：2003-10-21

申请号：US08996422

申请日：1997-12-22

申请人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

发明人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61K3155

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06632811B2

公开(公告)日：2003-10-14

申请号：US09915342

申请日：2001-07-27

申请人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

发明人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61K3155

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物，以及预防和治疗阿尔茨海默病的方法，该药物组合物均为该药物组合物。

公开(公告)号：US06544978B2

公开(公告)日：2003-04-08

申请号：US09915480

申请日：2001-07-27

申请人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

发明人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61K3155

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06541466B2

公开(公告)日：2003-04-01

申请号：US09915362

申请日：2001-07-27

申请人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

发明人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61K3155

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06667305B1

公开(公告)日：2003-12-23

申请号：US10336745

申请日：2003-01-06

申请人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

发明人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61P2528

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06951854B1

公开(公告)日：2005-10-04

申请号：US10951992

申请日：2004-09-29

申请人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

发明人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/55 ,  A61K38/04 ,  A61K38/05 ,  A61P25/28 ,  C07D223/18 ,  C07D471/04 ,  C07D471/06 ,  C07D471/08

CPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/5513 ,  A61K38/05 ,  C07C237/22 ,  C07C2603/32 ,  C07D223/18 ,  C07D307/33 ,  C07D311/76 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06683075B1

公开(公告)日：2004-01-27

申请号：US10336806

申请日：2003-01-06

申请人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

发明人： Jing Wu ,  Jay S. Tung ,  Eugene D. Thorsett ,  Michael A. Pleiss ,  Jeffrey S. Nissen ,  R. Jeffrey Neitz ,  Lee H. Latimer ,  Varghese John ,  Stephen Freedman ,  Thomas C. Britton ,  James A. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  James J. Droste ,  Steven S. Henry ,  Stacey L. McDaniel ,  William Leonard Scott ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61K3155

CPC分类号： C07D471/04 ,  A61K31/55 ,  C07D223/18 ,  C07D471/06 ,  C07D471/08

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。