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1.发明申请Thienoisoquinoline-phenylsulfonamides and their use as ER-NFkappaB inhibitors 失效噻吩并喹啉 - 苯基磺酰胺及其作为ER-NFkappaB抑制剂的用途公开(公告)号：US20060154875A1
公开(公告)日：2006-07-13
申请号：US11313140
申请日：2005-12-20
IPC分类号： A61K31/7052 , A61K31/4743 , C07D498/02
CPC分类号： C07D495/04
摘要： This invention provides estrogen receptor modulators having the structure: wherein R1 to R7 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供具有以下结构的雌激素受体调节剂：其中R 1至R 7如本说明书中所定义; 或其药学上可接受的盐。
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公开(公告)号：US20060173049A1
公开(公告)日：2006-08-03
申请号：US11344432
申请日：2006-01-31
申请人： Michael Malamas , William Fobare , William Solvibile , Frank Lovering , Jeffrey Condon , Albert Robichaud
发明人： Michael Malamas , William Fobare , William Solvibile , Frank Lovering , Jeffrey Condon , Albert Robichaud
IPC分类号： C07D403/02 , A61K31/4439
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14
摘要： The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的氨基 - 吡啶化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。
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3.发明申请Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation 失效氨基-5-（5元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途公开(公告)号：US20070004786A1
公开(公告)日：2007-01-04
申请号：US11478122
申请日：2006-06-29
申请人： Michael Malamas , Ping Zhou , William Fobare , William Solvibile , Iwan Gunawan , James Erdei , Yinfa Yan , Patrick Andrae , Dominick Quagliato
发明人： Michael Malamas , Ping Zhou , William Fobare , William Solvibile , Iwan Gunawan , James Erdei , Yinfa Yan , Patrick Andrae , Dominick Quagliato
IPC分类号： A61K31/427 , A61K31/422 , A61K31/4196 , C07D417/04 , C07D413/04 , C07D403/04
CPC分类号： C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译： 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法
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![Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase](/abs-image/US/2007/03/29/US20070072925A1/abs.jpg.150x150.jpg)
4.发明申请Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase 失效用于抑制β-分泌酶的氨基-5- [4-（二氟甲氧基）苯基] -5-苯基咪唑啉酮化合物公开(公告)号：US20070072925A1
公开(公告)日：2007-03-29
申请号：US11526511
申请日：2006-09-25
申请人： Michael Malamas , James Erdei , William Fobare , Dominick Quagliato , Schuyler Antane , Albert Robichaud
发明人： Michael Malamas , James Erdei , William Fobare , Dominick Quagliato , Schuyler Antane , Albert Robichaud
IPC分类号： A61K31/4166 , C07D233/34
CPC分类号： C07D233/88 , C07D401/12 , C07D409/12
摘要： The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的2-氨基-5- [4-（二氟甲氧基）苯基] -5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白的方法 沉积物和神经原纤维缠结。
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5.发明申请Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators 失效取代的噻吩基和呋喃基酰基胍及其用作β-分泌酶调节剂的方法公开(公告)号：US20060183792A1
公开(公告)日：2006-08-17
申请号：US11352646
申请日：2006-02-13
申请人： William Fobare , William Solvibile
发明人： William Fobare , William Solvibile
IPC分类号： A61K31/381 , C07D333/38
CPC分类号： C07D333/24 , C07D307/52 , C07D409/12
摘要： The present invention provides a substituted thienyl or furyl acylguanidine compound of formula I The present invention also provides methods for the inhibition of β-secretase (BACE) and for the treatment of β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的取代的噻吩基或呋喃基酰基胍化合物本发明还提供抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。
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