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公开(公告)号：US07557079B2
公开(公告)日：2009-07-07
申请号：US10539847
申请日：2003-12-23
申请人： Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Richard James Mitter , Ursula Boschert , Yolande Chvatchko
发明人： Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Richard James Mitter , Ursula Boschert , Yolande Chvatchko
CPC分类号： C12N9/6489 , C12N15/52
摘要： This invention relates to proteins termed INSP005a and INSP005b, herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及称为INSP005a和INSP005b的蛋白质，在本文中鉴定为分泌蛋白质，特别是金属蛋白酶家族的成员，以及来自编码基因的这些蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。
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公开(公告)号：US07622555B2
公开(公告)日：2009-11-24
申请号：US10706691
申请日：2003-11-12
申请人： Andrew Robert Davids , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Yolande Chvatchko , Ursula Boschert
发明人： Andrew Robert Davids , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Yolande Chvatchko , Ursula Boschert
CPC分类号： C07K14/70503
摘要： This invention relates to a novel protein (INSP052), herein identified as an immunoglobulin domain-containing cell surface recognition molecule and to the use of this proteins and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease. The invention also relates to the identification of the extracellular domain of INSP052.
摘要翻译： 本发明涉及本文鉴定为含有免疫球蛋白结构域的细胞表面识别分子的新型蛋白质（INSP052），以及来自编码基因的该蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。 本发明还涉及INSP052细胞外结构域的鉴定。
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3.发明授权Method of treatment comprising administration of a cytokine antagonist molecule 失效包括给予细胞因子拮抗剂分子的治疗方法公开(公告)号：US07803383B2
公开(公告)日：2010-09-28
申请号：US10579113
申请日：2004-11-12
申请人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
发明人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
IPC分类号： A61K39/00 , A61K39/395 , C07K14/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/10 , C07K2319/30 , Y02A50/401
摘要： This invention relates to novel uses of a protein sequence (INSP052EC), herein identified as an immunoglobulin domain-containing cell surface recognition, in the diagnosis, prevention and treatment of diseases, in particular those related to the excessive expression and/or secretion of cytokines.
摘要翻译： 本发明涉及本文鉴定为含有免疫球蛋白结构域的细胞表面识别的蛋白质序列（INSP052EC）在疾病的诊断，预防和治疗中的新用途，特别是与细胞因子的过度表达和/或分泌相关的那些 。
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公开(公告)号：US20080025951A1
公开(公告)日：2008-01-31
申请号：US10579113
申请日：2004-11-12
申请人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
发明人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
IPC分类号： A61K38/16 , A01K67/00 , A61K48/00 , A61P31/12 , C07H21/00 , C12N1/00 , C12N15/63 , C07K14/00 , A61P37/00 , A61P17/00 , A61K31/7088
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/10 , C07K2319/30 , Y02A50/401
摘要： This invention relates to novel uses of a protein sequence (INSP052EC), herein identified as an immunoglobulin domain-containing cell surface recognition, in the diagnosis, prevention and treatment of diseases, in particular those related to the excessive expression and/or secretion of cytokines.
摘要翻译： 本发明涉及本文鉴定为含有免疫球蛋白结构域的细胞表面识别的蛋白质序列（INSP052EC）在疾病的诊断，预防和治疗中的新用途，特别是与细胞因子的过度表达和/或分泌相关的那些 。
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公开(公告)号：US07605129B2
公开(公告)日：2009-10-20
申请号：US10539962
申请日：2003-12-19
申请人： Richard Joseph Fagan , Christopher Benjamin Phelps , Tania Maria Rodrigues , Christine Power , Mariastella De Tiani
发明人： Richard Joseph Fagan , Christopher Benjamin Phelps , Tania Maria Rodrigues , Christine Power , Mariastella De Tiani
CPC分类号： C07K14/61
摘要： This invention relates to a protein, termed INSP105, herein identified as a splice variant of human placental growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种称为INSP105的蛋白质，其在本文中被鉴定为人胎盘生长激素的剪接变体，以及来自编码基因的该蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。
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公开(公告)号：US20100048467A1
公开(公告)日：2010-02-25
申请号：US12159541
申请日：2006-01-12
申请人： Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson , Yan Lavrovsky
发明人： Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson , Yan Lavrovsky
IPC分类号： A61K38/16 , A61K31/7088 , A61P35/00
CPC分类号： A61K38/18
摘要： This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种新型蛋白质（INSP002），其被鉴定为分泌型蛋白质，其是胱氨酸 - 结折叠细胞因子超家族的丹氏家族的成员，并且使用该蛋白质和来自编码基因的核酸序列 诊断，预防和治疗疾病。
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公开(公告)号：US20090214548A1
公开(公告)日：2009-08-27
申请号：US11721291
申请日：2005-12-08
IPC分类号： A61K39/395 , A61K39/00 , A61K35/00 , A61K38/43 , C12Q1/68 , G01N33/53 , C40B40/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K31/7088 , C07K14/435 , A01K67/00
CPC分类号： C07K14/71 , A61K38/00 , G01N33/74 , G01N2333/71
摘要： There are provided proteins containing a domain corresponding to the C-terminal half of a ZP domain similar to that identified in TGF-beta Receptor III and the use of the proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of diseases. In particular, the present invention relates to the use of the disclosed proteins for modulating the activity of proteins belonging to the TGF-beta superfamily.
摘要翻译： 提供的蛋白质含有对应于与TGF-β受体III中鉴定的ZP结构域的C末端半部分相关的结构域，以及来自编码基因的蛋白质和核酸序列在诊断，预防和治疗中的用途 疾病 特别地，本发明涉及所公开的蛋白质用于调节属于TGF-β超家族的蛋白质的活性的用途。
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公开(公告)号：US07619065B2
公开(公告)日：2009-11-17
申请号：US10872898
申请日：2004-06-21
申请人： Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson
发明人： Mark Douglas Davies , Christopher Benjamin Phelps , Richard Joseph Fagan , Christine Power , Melanie Yorke , Mark Ibberson
摘要： This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种新型蛋白质（INSP002），其被鉴定为分泌型蛋白质，其是胱氨酸 - 结折叠细胞因子超家族的丹氏家族的成员，并且使用该蛋白质和来自编码基因的核酸序列 诊断，预防和治疗疾病。
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公开(公告)号：US07514533B2
公开(公告)日：2009-04-07
申请号：US10557400
申请日：2003-05-21
申请人： Stephen Noel Fitzgerald , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Mark Ibberson , Melanie Yorke
发明人： Stephen Noel Fitzgerald , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Mark Ibberson , Melanie Yorke
CPC分类号： A01K2217/075 , A61K38/00 , C07K14/472 , C07K14/525
摘要： This invention relates to novel protein INSP058, herein identified as TNF-like secreted protein, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及本文鉴定为TNF-样分泌蛋白的新型蛋白质INSP058，以及该蛋白质和来自编码基因的核酸序列在疾病的诊断，预防和治疗中的用途。
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公开(公告)号：US07531508B2
公开(公告)日：2009-05-12
申请号：US10537142
申请日：2003-12-05
申请人： Richard Joseph Fagan , Christopher Benjamin Phelps , Tania Maria Rodrigues , Melanie Yorke , Mariastella De Tiani
发明人： Richard Joseph Fagan , Christopher Benjamin Phelps , Tania Maria Rodrigues , Melanie Yorke , Mariastella De Tiani
IPC分类号： A61K38/27 , C07K14/475
CPC分类号： C07K14/61 , A01K2217/05 , A01K2217/075
摘要： This invention relates to a novel protein, termed INSP101, herein identified as a novel splice variant of human pituitary growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及一种称为INSP101的新型蛋白质，在本文中被鉴定为人垂体生长激素的新型剪接变体，以及在诊断，预防和治疗疾病中使用该蛋白质和来自编码基因的核酸序列。
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