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公开(公告)号：US20120260671A1
公开(公告)日：2012-10-18
申请号：US13434345
申请日：2012-03-29
申请人： Richard L. DAMREN , Colin Tuohey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
发明人： Richard L. DAMREN , Colin Tuohey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
CPC分类号： C12M29/26 , B01D5/0042 , B01D5/0093 , B01D46/4263 , B01D53/265 , C12M23/28 , C12M29/04 , C12M41/12
摘要： Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioretractor, forming a dry gas stream for entering or leaving the bioreactor.
摘要翻译： 本文公开了一种系统和方法，用于冷凝进入生物反应器或留下生物减馏器的湿气流中的水分，形成用于进入或离开生物反应器的干燥气流。
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公开(公告)号：US09499781B2
公开(公告)日：2016-11-22
申请号：US13434345
申请日：2012-03-29
申请人： Richard Damren , Colin Touhey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
发明人： Richard Damren , Colin Touhey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
CPC分类号： C12M29/26 , B01D5/0042 , B01D5/0093 , B01D46/4263 , B01D53/265 , C12M23/28 , C12M29/04 , C12M41/12
摘要： Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, forming a dry gas stream for entering or leaving the bioreactor.
摘要翻译： 本文公开了一种用于冷凝进入生物反应器或离开生物反应器的湿气流中的水分的系统和方法，形成用于进入或离开生物反应器的干燥气流。
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公开(公告)号：US09127242B2
公开(公告)日：2015-09-08
申请号：US13262155
申请日：2010-04-05
申请人： Patrick M. Guertin , Parrish M. Galliher , Michael Fisher , Joseph D. Crowell , Colin R. Tuohey , Laura A. Niklason , William E. Tente , Shannon M. Dahl , Juliana Blum , Justin Strader
发明人： Patrick M. Guertin , Parrish M. Galliher , Michael Fisher , Joseph D. Crowell , Colin R. Tuohey , Laura A. Niklason , William E. Tente , Shannon M. Dahl , Juliana Blum , Justin Strader
摘要： A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit that provides full environmental control of cell culture conditions.
摘要翻译： 单次使用，单次或多次组织，器官和移植物生物反应器和环境控制系统被设计为复制组织，器官或移植物生长所必需的条件，同时解决扩大组织生长的问题; 适应一次性或一次性格式; 作为提供细胞培养条件的全面环境控制的独立单元的操作。
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公开(公告)号：US20120028234A1
公开(公告)日：2012-02-02
申请号：US13262155
申请日：2010-04-05
申请人： Patrick M. Guertin , Parrish M. Galliher , Michael Fisher , Joseph D. Crowell , Colin R. Tuohey , Laura A. Niklason , William E. Tente , Shannon M. Dahl , Juliana Blum , Justin Strader
发明人： Patrick M. Guertin , Parrish M. Galliher , Michael Fisher , Joseph D. Crowell , Colin R. Tuohey , Laura A. Niklason , William E. Tente , Shannon M. Dahl , Juliana Blum , Justin Strader
摘要： A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit that provides full environmental control of cell culture conditions.
摘要翻译： 单次使用，单次或多次组织，器官和移植物生物反应器和环境控制系统被设计为复制组织，器官或移植物生长所必需的条件，同时解决扩大组织生长的问题; 适应一次性或一次性格式; 作为提供细胞培养条件的全面环境控制的独立单元的操作。
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公开(公告)号：US5631159A
公开(公告)日：1997-05-20
申请号：US124676
申请日：1993-09-22
CPC分类号： C12N5/0037 , C12N2500/36
摘要： Methods are provided for producing serum-free, animal cell culture media which have enhanced cell culture properties, such as cell growth, cell viability and protein production properties. The cell culture properties of standard serum-free media formulations, which include compositions such as inorganic salts, glucose, fatty acids, amino acids and vitamins, can be enhanced according to the methods of the invention, by providing the media with an additive. The additive in one embodiment can be produced by the acid or base catalyzed hydrolysis of a phosphoglyceride.
摘要翻译： 提供了用于生产具有增强的细胞培养性能，例如细胞生长，细胞活力和蛋白质生产性质的无血清动物细胞培养基的方法。 根据本发明的方法，通过向培养基中提供添加剂，可以增强包括组合物如无机盐，葡萄糖，脂肪酸，氨基酸和维生素在内的标准无血清培养基制剂的细胞培养性能。 在一个实施方案中，添加剂可以通过酸或碱催化的磷酸甘油酯水解产生。
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6.发明授权公开(公告)号：US08741312B2
公开(公告)日：2014-06-03
申请号：US13012917
申请日：2011-01-25
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , Y02A50/388
摘要： The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.
摘要翻译： 本发明提供了一种非活性的非复制疫苗，其包含完整的病毒体，化学灭活的黄热病病毒，其使用确保保存关键的中和表位的方法灭活。 黄热病病毒已经适应于在细胞中传播比未适应病毒更高的产量。 本发明还提供了防止黄热病毒感染的方法。
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