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公开(公告)号：US5856507A
公开(公告)日：1999-01-05
申请号：US786523
申请日：1997-01-21
申请人： Richard P. Polniaszek , Xuebao Wang , Jeffrey S. DePue , Chennagiri R. Pandit , Kumar G. Gadamasetti , Yadagiri Pendri , Eduardo J. Martinez
发明人： Richard P. Polniaszek , Xuebao Wang , Jeffrey S. DePue , Chennagiri R. Pandit , Kumar G. Gadamasetti , Yadagiri Pendri , Eduardo J. Martinez
IPC分类号： C07D263/32 , C07D405/12 , C07D413/12
CPC分类号： C07D405/12 , C07D263/32
摘要： Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
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公开(公告)号：US06515136B1
公开(公告)日：2003-02-04
申请号：US09141402
申请日：1998-08-27
申请人： Richard P. Polniaszek , Xuebao Wang , Jeffrey S. DePue , Chennagiri R. Pandit , Kumar G. Gadamasetti , Yadagiri Pendri , Eduardo J. Martinez
发明人： Richard P. Polniaszek , Xuebao Wang , Jeffrey S. DePue , Chennagiri R. Pandit , Kumar G. Gadamasetti , Yadagiri Pendri , Eduardo J. Martinez
IPC分类号： C07D41312
CPC分类号： C07D405/12 , C07D263/32
摘要： Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
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3.发明申请Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids 审中-公开制备4-（联苯基）氮杂环丁烷-2-酮膦酸的方法公开(公告)号：US20090099355A1
公开(公告)日：2009-04-16
申请号：US11915241
申请日：2006-05-25
申请人： Stephen Antonelli , Timothy C. Barden , Peter Lee , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley
发明人： Stephen Antonelli , Timothy C. Barden , Peter Lee , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley
IPC分类号： C07D205/08 , C07D263/22 , C07C211/28 , C07F9/38
CPC分类号： C07C251/24 , C07D205/08 , C07D263/26 , C07D309/30 , C07D309/38 , C07F7/1892 , C07F9/568
摘要： The present invention relates to processes for the production of 4-(biphenylyl)azetidin-2-one phosphonic acid derivatives of formula
摘要翻译： 本发明涉及制备式（I）的4-（联苯基）吖丁啶-2-酮膦酸衍生物的方法
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公开(公告)号：US20090131395A1
公开(公告)日：2009-05-21
申请号：US11913461
申请日：2006-05-05
申请人： Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley , Timothy C. Barden , JingJing Yang , Daniel P. Zimmer
发明人： Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley , Timothy C. Barden , JingJing Yang , Daniel P. Zimmer
IPC分类号： A61K31/397 , C07D205/08 , A61P9/10
CPC分类号： C07D205/08 , C07D405/10 , C07F9/568 , C07F9/65586 , C07H7/04 , C07H15/203
摘要： The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula I: Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.
摘要翻译： 本发明涉及可用于治疗高胆固醇血症和其他疾病的4-联苯-1-苯基氮杂环丁烷-2-酮的化学属。 该化合物具有通式I：还公开了用于治疗胆固醇和脂质相关疾病的药物组合物和方法。
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5.发明申请公开(公告)号：US20080200669A1
公开(公告)日：2008-08-21
申请号：US11913958
申请日：2006-05-11
IPC分类号： C07D205/08 , C07C225/22 , C07C251/24 , C07D263/22
CPC分类号： C07D263/14 , C07D205/08 , C07F7/1892
摘要： The present invention relates to processes for the production of phenolic 4-biphenylylazetidin-2-one derivatives of formula
摘要翻译： 本发明涉及制备下式的酚类4-联苯基氮杂环丁烷-2-酮衍生物的方法
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公开(公告)号：US5892106A
公开(公告)日：1999-04-06
申请号：US99472
申请日：1998-06-18
IPC分类号： C07C205/56 , C07D209/34 , C07C205/06
CPC分类号： C07C201/12 , C07C227/04 , C07D209/34 , Y02P20/55
摘要： The present invention relates to novel intermediates of the formula ##STR1## wherein the wavy bond () represents the racemate, the (R)-enantiomer or the (S)-enantiomer; and R is hydrogen, a carboxyl-protecting group or a cation of an addition salt; or solvate thereof; and to the use thereof in a process for the preparation of certain 3-fluoro oxindole derivatives.
摘要翻译： 本发明涉及式（IMAGE）的新型中间体，其中波状键（+ Z）表示外消旋物，（R） - 对映异构体或（S） - 对映体; R为氢，羧基保护基或加成盐的阳离子; 或其溶剂合物; 以及在制备某些3-氟羟吲哚衍生物的方法中的用途。
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公开(公告)号：US5808095A
公开(公告)日：1998-09-15
申请号：US946393
申请日：1997-10-07
IPC分类号： C07C205/56 , C07D209/34 , C07D209/12
CPC分类号： C07C201/12 , C07C227/04 , C07D209/34 , Y02P20/55
摘要： The present invention relates to novel intermediates of the formula ##STR1## wherein the wavy bond () represents the racemate, the (R)-enantiomer or the (S)-enantiomer; and R is hydrogen, a carboxyl-protecting group or a cation of an addition salt; or solvate thereof; and to the use thereof in a process for the preparation of certain 3-fluoro oxindole derivatives.
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公开(公告)号：US20080167255A1
公开(公告)日：2008-07-10
申请号：US11954170
申请日：2007-12-11
申请人： Eduardo J. Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
发明人： Eduardo J. Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
IPC分类号： A61K31/7052 , C07D205/04 , A61K31/397 , A61K31/69 , A61P9/00 , A61K31/66 , C07H15/00
CPC分类号： C07D205/08 , A61K31/337 , A61K31/397 , A61K45/06 , C07D263/20 , C07D401/04 , C07D405/10 , C07D409/04 , C07D453/02 , C07F7/1804 , C07F9/568 , C07H7/04 , C07H15/203 , A61K2300/00
摘要： 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
摘要翻译： 公开了可用于治疗高胆固醇血症的4-二苄基-1-苯基氮杂环丁-2-酮。 该化合物具有以下通式：其中
表示芳基或杂芳基残基; Ar表示芳基残基; U是2至6个原子链; R代表取代基。
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公开(公告)号：US20080287663A1
公开(公告)日：2008-11-20
申请号：US11913587
申请日：2006-05-08
申请人： Peter Lee , Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley
发明人： Peter Lee , Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley
IPC分类号： C07H7/04
CPC分类号： C07C251/24 , C07C229/34 , C07D205/08 , C07D263/26 , C07D405/10 , C07F5/025 , C07F7/1804 , C07F7/1892
摘要： The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formula
摘要翻译： 本发明涉及制备式的4-联苯基氮杂环丁烷-2-酮衍生物的方法
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10.发明申请4-Biarylyl-1-Phenylazetidin-2-One Glucuronide Derivatives for Hypercholesterolemia 审中-公开用于高胆固醇血症的4-二环戊基-1-苯基氮杂环丁烷-2-酮葡糖苷酸衍生物公开(公告)号：US20080194494A1
公开(公告)日：2008-08-14
申请号：US11912558
申请日：2006-04-26
IPC分类号： A61K31/7052 , C07H15/26 , C07D205/08 , A61P3/06 , A61P9/10
CPC分类号： C07H7/04 , C07D205/08 , C07H15/26
摘要： The invention relates to a chemical genus of 4-biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia and other disorders, having general formula: Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.
摘要翻译： 本发明涉及用于治疗高胆固醇血症和其它病症的4-二芳基-1-苯基氮杂环丁烷-2-酮的化学属，具有以下通式：还公开了治疗胆固醇和脂类相关疾病的药物组合物和方法。
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