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    Production of monoclonal antibodies
    1.
    发明授权
    Production of monoclonal antibodies 失效
    生产单克隆抗体

    公开(公告)号：US5426037A

    公开(公告)日：1995-06-20

    申请号：US167801

    申请日：1993-12-14

    申请人： Richard Pannell ,  Cesar Milstein

    发明人： Richard Pannell ,  Cesar Milstein

    IPC分类号： C12M1/10 ,  C12M3/04 ,  C12M3/06 ,  C12N5/08 ,  C12P21/08 ,  C12M3/00 ,  C12M1/28

    CPC分类号： C12M27/12 ,  C12M27/00 ,  C12M29/04

    摘要： Apparatus and method for the production of monoclonal antibodies, wherein a sealed dialysis tube (18) is fixed within a roller bottle (10) to be immersed in a growth medium (24) contained within the roller bottle, the dialysis tube is filled with a culture of hybridomas (20) to the extent that a bubble (22) remains within the tube, and the bottle is rotated or otherwise moved in order to cause the bubble to oscillate back and forth from one end of the tube to the other.

    摘要翻译： PCT No.PCT / GB92 / 00982 Sec。 371日期：1993年12月14日 102（e）日期1993年12月14日PCT提交1992年6月1日PCT公布。 出版物WO92 / 22634 PCT 日本1992年12月23日。用于生产单克隆抗体的装置和方法，其中将密封的透析管（18）固定在辊瓶（10）内以浸没在容纳在所述滚瓶内的生长培养基（24） 透析管填充有杂交瘤（20）的培养物，使得气泡（22）保留在管内，并且瓶子被旋转或以其他方式移动，以使气泡从 管到另一个。

    Method for seed bed treatment before a polymerization reaction
    2.
    发明申请
    Method for seed bed treatment before a polymerization reaction 审中-公开
    聚合反应前种子床处理方法

    公开(公告)号：US20070073012A1

    公开(公告)日：2007-03-29

    申请号：US11236998

    申请日：2005-09-28

    申请人： Richard Pannell ,  Agapios Agapiou ,  Eric Markel

    发明人： Richard Pannell ,  Agapios Agapiou ,  Eric Markel

    IPC分类号： C08F2/00

    CPC分类号： C08F10/00 ,  Y02P20/582 ,  C08F2/34 ,  C08F2/005

    摘要： In some embodiments, a method in which at least one continuity additive (“CA”) and a seed bed are pre-loaded into a reactor, and a polymerization reaction is optionally then performed in the reactor. In other embodiments, at least one flow improver, at least one CA, and a seed bed are pre-loaded into a reactor. Pre-loading of a reactor with a CA can significantly improve continuity of a subsequent polymerization reaction in the reactor during its initial stages, including by reducing sheeting and fouling. The CA can be pre-loaded in dry form (e.g., as a powder), or in liquid or slurry form (e.g., as an oil slurry). To aid delivery of a dry CA to the reactor and combination of the dry CA with a seed bed in the reactor, the dry CA can be combined with a flow improver and the combination of CA and flow improver then loaded into the reactor. Alternatively, the CA and flow improver can be sequentially loaded into the reactor, and then mixed together (and mixed with a seed bed) in the reactor after both the CA and flow improver have been separately loaded into the reactor.

    摘要翻译： 在一些实施方案中，将至少一种连续性添加剂（“CA”）和种子床预加载到反应器中的方法，然后任选地在反应器中进行聚合反应。 在其它实施方案中，将至少一种流动改进剂，至少一种CA和种子床预加载到反应器中。 具有CA的反应器的预装载可以显着改善反应器在其初始阶段期间的后续聚合反应的连续性，包括通过减少薄片和结垢。 CA可以预干燥形式（例如，作为粉末），或以液体或浆液形式（例如，作为油浆）预加载。 为了帮助将干燥的CA输送到反应器中，并且干燥的CA与反应器中的种子床的组合，干燥的CA可与流动改进剂组合，然后将CA和流动改进剂的组合装入反应器中。 或者，CA和流动改进剂可以顺序地加载到反应器中，然后在CA和流动改进剂已经分别装载到反应器中之后混合在一起（并与种子床混合）在反应器中。

    Method for determining temperature value indicative of resin stickiness from data generated by polymerization reaction monitoring
    5.
    发明申请
    Method for determining temperature value indicative of resin stickiness from data generated by polymerization reaction monitoring 有权
    用于通过聚合反应监测产生的数据确定指示树脂粘性的温度值的方法

    公开(公告)号：US20070073010A1

    公开(公告)日：2007-03-29

    申请号：US11599122

    申请日：2006-11-14

    申请人： Richard Pannell ,  Robert Hagerty ,  Eric Markel

    发明人： Richard Pannell ,  Robert Hagerty ,  Eric Markel

    IPC分类号： C08F2/00

    CPC分类号： C08F210/16 ,  C08F2400/02 ,  C08F2/005 ,  C08F2/00 ,  C08F2/34 ,  C08F210/14 ,  C08F2500/12

    摘要： In some embodiments, a method including the steps of monitoring a polymerization reaction which produces a polymer resin in a fluid bed reactor, where a dry melt reference temperature is characteristic of melting behavior of a dry version of the resin, and in response to data indicative of at least one monitored parameter of the reaction, determining a reduced melt reference temperature that is at least substantially equal to the difference between the dry melt reference temperature and a temperature by which the dry melt reference temperature is depressed by the presence of condensable diluent gas with the resin in the reactor. Optionally, the method also includes the step of controlling the reaction in response to the reduced melt reference temperature or a stickiness parameter determined from the reduced melt reference temperature.

    摘要翻译： 在一些实施方案中，一种方法包括以下步骤：监测在流化床反应器中产生聚合物树脂的聚合反应，其中干燥熔体参考温度是干燥形式的树脂的熔融特性的特征，并且响应于数据指示 的至少一个监测的反应参数，确定降低的熔融参考温度，其至少基本上等于干熔体参考温度与通过存在可冷凝稀释气体而使干熔体参考温度下降的温度之间的差异 与反应器中的树脂。 任选地，该方法还包括响应于降低的熔融参考温度或从降低的熔融参考温度确定的粘性参数来控制反应的步骤。