摘要:
Methods of determining the ratio of apolipoprotein B-100 to apolipoprotein A-I using ELISA techniques in conjunction with monoclonal paratopic molecules are disclosed as are diagnostic systems useful in performing those determinations. Monoclonal paratopic molecules secreted by hybridomas having ATCC accession numbers HB 8742, HB 8746, HB 9200 and HB 9201 are utilized.
摘要:
Methods and compositions are described for determining the level of low density lipoproteins (LDL) in plasma. Native apoprotein B-100 (apo B-100) present in LDL particles is immunologically mimicked by a polypeptide of the invention. A polypeptide includes an amino acid residue sequence corresponding to a pan epitope region of the target apoprotein. A preferred polypeptide is a fusion protein that simultaneously mimics native apo B-100 and native apo A-I. Improved assay systems and methods for determining HDL and LDL levels in a body fluid sample are also described.
摘要:
Methods and compositions are described for determining the level of low density lipoproteins (LDL) in plasma. Native apoprotein B-100 (apo B-100) present in LDL particles is immunologically mimicked by a polypeptide of the invention. A polypeptide includes an amino acid residue sequence corresponding to a pan epitope region of the target apoprotein. A preferred polypeptide is a fusion protein that simultaneously mimics native apo B-100 and native apo A-I. Improved assay systems and methods for determining HDL and LDL levels in a body fluid sample are also described.
摘要:
The present invention describes an Apo AI polypeptide capable of immunologically mimicking an Apo AI epitope. The polypeptide is useful in diagnostic methods and systems for detecting Apo AI in vascular fluid samples, and for preparation of anti-Apo AI antibodies. In addition, the polypeptide is useful in therapeutic methods for increasing esterified cholesterol in a human patient.
摘要:
The present invention describes a monoclonal antibody that is directed against an Apo AI/HLD epitope whose expression is substantially unaffected by deamidation. Also disclosed is a polypeptide capable of immunologically mimicking an Apo AI/HLD epitope whose expression is substantially unaffected by deamidation. Diagnostic systems and methods for determining the amount of Apo AI in a vascular fluid sample using a disclosed monoclonal antibody and/or a disclosed polypeptide are also described.
摘要翻译:本发明描述了针对Apo AI / HLD表位的单克隆抗体,其表达基本上不受脱酰胺作用的影响。 还公开了能够免疫模拟Apo AI / HLD表位的多肽,其表达基本上不受脱酰胺的影响。 还描述了使用公开的单克隆抗体和/或所公开的多肽来测定血管液样品中Apo AI的量的诊断系统和方法。
摘要:
This invention relates generally to: (1) methods of forming enhanced-surface walls (20) for use in apparatae (e.g., heat transfer devices, fluid mixing devices, etc.) for performing a process, (2) to enhanced-surface walls per se, and (3) to various apparatae incorporating such enhanced-surface walls.The method improved method broadly comprises the steps of: providing a length of material (21) having opposite initial surfaces (22a, 22b), said material having a longitudinal centerline (x-x) positioned substantially midway between said initial surfaces, said material having an initial transverse dimension measured from said centerline to a point on either of said initial surfaces located farthest away from said centerline, each of said initial surfaces having a initial surface density, said surface density being defined as the number of characters on an surface per unit of projected surface area; impressing secondary patterns (23a, 23b) having secondary pattern surface densities onto each of said initial surfaces to distort said material and to increase the surface densities on each of said surfaces and to increase the trans-verse dimension of said material from said centerline to the farthest point of such distorted material; and impressing primary patterns (25a, 25b) having primary pattern surface densities onto each of such distorted surfaces to further distort said material and to further increase the surface densities on each of said surfaces; thereby to provide an enhanced-surface wall for use in an apparatus for performing a process.
摘要:
A device and method for manufacture thereof having a one or more cantilevered cutting teeth integrally formed in raised configuration on a flat base fro cutting food items moved along said base. The free end portion is formed by upper and lower etched out portions of the upper end of said cutting teeth to form a cutting edge. The upper surface of the upper cut-out portion of the teeth is situation at a position out contact with food items being cut. A substantially portion of the teeth is coated with a low friction material, except for the cutting edge In a second embodiment one or more domed cutting elements are cut out of base sheet and may include a leading V-shaped cutting edge.
摘要:
An electric sharpener having two pairs of interlocking abrasives for sharpening the edge of blades to different sharpening angles. An adjustment assembly simultaneously moves the wheels of each pair either toward or away from each other to adjust the sharpening angle produced by pair of abrasive wheels in a sharpening operation. The adjustment assembly is provided with a rotatable shaft having an external handle which engages a lower platen. The lower end of the shaft is threaded to move the platen in vertical direction to move translation bars affixed to the platen. The translation bars extend through elongated slots in respective pairs of adjustment arms coupled to each pair of abrasive wheels to rotate and vary the spacing between the abrasive wheels and adjust sharpening angles.
摘要:
An adjustable manual abrasive sharpener having a pair of sharpening slots formed in a frame with opposing abrasive arms being pivotally mounted in each of the sharpening slots. A rod is mounted on the frame for rotatable motion and for linear motion long its axis of rotation from a position at which the rod is locked against rotation to a depressed position whereby the rod may be rotated. The bottom end portion of the rod includes a pinion gear which engages a pair of gear racks which are mounted for movement laterally relative to the axis of rotation of the rod. The pair of gear racks respectively engage slots formed on the bottom of the abrasive arms in each sharpening slot. Rotation of the rod causes movement of the gear racks to adjust each pair of abrasive arms with respect to each other to vary the sharpening angle of the abrasive elements.