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1.发明授权APO AI polypeptides, diagnostic methods and systems for quantifying APO AI, and therapeutic methods 失效APO AI多肽，用于定量APO AI的诊断方法和系统以及治疗方法
公开(公告)号：US5814467A
公开(公告)日：1998-09-29
申请号：US292870
申请日：1994-08-19
IPC分类号： A61K38/00 , A61K39/395 , A61P3/06 , C07K7/08 , C07K14/775 , C07K16/00 , C07K16/18 , C12N15/02 , C12P21/08 , G01N33/53
CPC分类号： C07K16/18 , C07K14/775 , A61K38/00 , Y10S435/975 , Y10S530/811 , Y10S530/812
摘要： The present invention describes an Apo AI polypeptide capable of immunologically mimicking an Apo AI epitope. The polypeptide is useful in diagnostic methods and systems for detecting Apo AI in vascular fluid samples, and for preparation of anti-Apo AI antibodies. In addition, the polypeptide is useful in therapeutic methods for increasing esterified cholesterol in a human patient.
摘要翻译： 本发明描述了能够免疫模拟Apo AI表位的Apo AI多肽。 该多肽可用于检测血管液样品中Apo AI的诊断方法和系统，并用于制备抗Apo AI抗体。 此外，该多肽可用于增加人类患者中酯化胆固醇的治疗方法。
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公开(公告)号：US5786206A
公开(公告)日：1998-07-28
申请号：US333577
申请日：1994-10-31
申请人： Richard S. Smith , Linda K. Curtiss , Kanaka Raju Koduri , Joseph L. Witztum , Stephen G. Young
发明人： Richard S. Smith , Linda K. Curtiss , Kanaka Raju Koduri , Joseph L. Witztum , Stephen G. Young
IPC分类号： A61K38/00 , C07K14/775 , C12N1/21 , C07H21/04 , C12N15/63
CPC分类号： C07K14/775 , A61K38/00 , C07K2319/00 , C07K2319/40
摘要： Methods and compositions are described for determining the level of low density lipoproteins (LDL) in plasma. Native apoprotein B-100 (apo B-100) present in LDL particles is immunologically mimicked by a polypeptide of the invention. A polypeptide includes an amino acid residue sequence corresponding to a pan epitope region of the target apoprotein. A preferred polypeptide is a fusion protein that simultaneously mimics native apo B-100 and native apo A-I. Improved assay systems and methods for determining HDL and LDL levels in a body fluid sample are also described.
摘要翻译： 描述了用于确定血浆中低密度脂蛋白（LDL）水平的方法和组合物。 LDL颗粒中存在的天然载脂蛋白B-100（载脂蛋白B-100）由本发明的多肽免疫模拟。 多肽包括对应于目标载脂蛋白的泛表位区域的氨基酸残基序列。 优选的多肽是同时模拟天然载脂蛋白B-100和天然载脂蛋白A-I的融合蛋白。 还描述了用于测定体液样品中HDL和LDL水平的改进的测定系统和方法。
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公开(公告)号：US5182364A
公开(公告)日：1993-01-26
申请号：US485158
申请日：1990-02-26
申请人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
发明人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
IPC分类号： A61K38/00 , C07K14/775 , C07K16/18
CPC分类号： C07K14/775 , C07K16/18 , A61K38/00
摘要： The present invention contemplates a method for treating hypercholesterolemia in a patient, which method comprises administering to the patient an LDL plasma concentration-reducing amount of a multimeric polypeptide capable of binding the LDL receptor. THe repeating unit of the polypeptide has an amino acid residue sequence corresponding to that represented by the formula LRKLRKRLLRDADDL.
摘要翻译： 本发明涉及用于治疗患者的高胆固醇血症的方法，该方法包括向患者施用LDL血浆浓度降低量的能够结合LDL受体的多聚体多肽。 所述多肽的重复单元具有对应于由式LRKLRKRLLRDADDL表示的氨基酸残基序列。
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公开(公告)号：US5177189A
公开(公告)日：1993-01-05
申请号：US395732
申请日：1989-08-18
申请人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
发明人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
IPC分类号： A61K38/00 , C07K14/775 , C07K16/18
CPC分类号： C07K16/18 , C07K14/775 , A61K38/00
摘要： The present invention contemplates a multimeric polypeptide capable of mimicking the ability of Apo E in regulating lymphocyte proliferation and ovarian androgen synthesis. The polypeptide has an amino acid residue sequence represented by the formula ##STR1##
摘要翻译： 本发明考虑了能够模拟Apo E调节淋巴细胞增殖和卵巢雄激素合成的能力的多聚体多肽。 该多肽具有由式NH2-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu- Leu-Arg-Asp-Ala-Asp-Asp-Leu- Leu-Arg-Lys- Leu-Arg-Lys-Arg-Leu- Leu-Arg-Asp-Ala-Asp-Asp-Leu-COOH。
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5.发明授权Diagnostic systems and methods using polypeptide analogs of apolipoprotein E 失效诊断系统和使用APOPOOPOPTETE E的多肽类似物的方法
公开(公告)号：US5168045A
公开(公告)日：1992-12-01
申请号：US540363
申请日：1990-06-18
申请人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
发明人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
IPC分类号： A61K38/00 , A61K38/04 , A61K39/395 , A61P3/06 , A61P7/00 , A61P37/06 , C07K7/08 , C07K14/775 , C07K16/00 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53
CPC分类号： C07K16/18 , C07K14/775 , A61K38/00
摘要： Apo E polypeptides capable of mimicking apolipoprotein E are described that are useful to prepare diagnostic antibodies, and for use in diagnostic systems and methods for detecting apo E antigens in vascular body fluids.
摘要翻译： 描述了能够模拟载脂蛋白E的Apo E多肽，其可用于制备诊断抗体，并且用于诊断系统和用于检测血管体液中的载脂蛋白E抗原的方法。
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公开(公告)号：US5126240A
公开(公告)日：1992-06-30
申请号：US913061
申请日：1986-09-29
申请人： Linda K. Curtiss
发明人： Linda K. Curtiss
IPC分类号： C12N15/02 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/18 , C07K19/00 , C12N5/10 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/50 , G01N33/53 , G01N33/577
CPC分类号： C07K16/18 , Y10S435/81 , Y10S436/808 , Y10S530/806
摘要： Hybridomas and their secreted paratopic molecules that immunoreact with apolipoprotein A-I are disclosed, as are assay methods for determining the presence and amount of apo A-I, and diagnostic systems useful in performing those determinations. Monoclonal paratopic molecules secreted by hybridomas having ATCC accession numbers HB 9200, HB 9201, HB 9202, HB 9203 and HB 9204 are utilized.
摘要翻译： 公开了与载脂蛋白A-1免疫反应的杂交瘤及其分泌的副相分子，以及用于确定载脂蛋白A-I的存在和量以及用于进行这些测定的诊断系统的测定方法。 利用具有ATCC登录号HB 9200，HB 9201，HB 9202，HB 9203和HB 9204的杂交瘤分泌的单克隆副变应性分子。
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7.发明授权Assay method and diagnostic system for determining the ratio of APO B-100 to APO A-I in a blood sample 失效用于确定血液样品中APO B-100与APO A-I的比例的测定方法和诊断系统
公开(公告)号：US4828986A
公开(公告)日：1989-05-09
申请号：US913140
申请日：1986-09-29
CPC分类号： G01N33/92 , G01N2800/044 , Y10S435/81 , Y10S435/948 , Y10S530/809
摘要： Methods of determining the ratio of apolipoprotein B-100 to apolipoprotein A-I using ELISA techniques in conjunction with monoclonal paratopic molecules are disclosed as are diagnostic systems useful in performing those determinations. Monoclonal paratopic molecules secreted by hybridomas having ATCC accession numbers HB 8742, HB 8746, HB 9200 and HB 9201 are utilized.
摘要翻译： 公开了使用ELISA技术结合单克隆副作用分子来确定载脂蛋白B-100与载脂蛋白A-1的比例的方法，作为用于进行这些测定的诊断系统。 利用具有ATCC登录号HB 8742，HB 8746，HB 9200和HB 9201的杂交瘤分泌的单克隆互补分子。
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8.发明授权Diagnostic assay for the presence of apolipoproteins associated with plasma high density lipoproteins 失效与血浆高密度脂蛋白相关的载脂蛋白的存在的诊断测定
公开(公告)号：US4677057A
公开(公告)日：1987-06-30
申请号：US710038
申请日：1985-03-11
IPC分类号： G01N33/53 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/18 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/92 , G01N33/543
CPC分类号： G01N33/92 , C07K16/18 , G01N2800/044 , Y10S435/948 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S530/808 , Y10S530/809 , Y10S530/864
摘要： Monoclonal receptors that immunologically bind to human apolipoprotein A molecules, particularly apo-A-I and apo-A-II, are described as are their methods of use and articles of manufacture containing them.
摘要翻译： 与人载脂蛋白A分子，特别是载脂蛋白A-I和载脂蛋白A-II免疫结合的单克隆受体，被描述为它们的使用方法和含有它们的制品。
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公开(公告)号：US5055396A
公开(公告)日：1991-10-08
申请号：US116248
申请日：1987-11-02
申请人： Linda K. Curtiss , Richard S. Smith
发明人： Linda K. Curtiss , Richard S. Smith
IPC分类号： G01N33/53 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/775 , C07K16/00 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/18 , Y10S435/81 , Y10S436/808 , Y10S530/806
摘要： The present invention describes a monoclonal antibody that is directed against an Apo AI/HLD epitope whose expression is substantially unaffected by deamidation. Also disclosed is a polypeptide capable of immunologically mimicking an Apo AI/HLD epitope whose expression is substantially unaffected by deamidation. Diagnostic systems and methods for determining the amount of Apo AI in a vascular fluid sample using a disclosed monoclonal antibody and/or a disclosed polypeptide are also described.
摘要翻译： 本发明描述了针对Apo AI / HLD表位的单克隆抗体，其表达基本上不受脱酰胺作用的影响。 还公开了能够免疫模拟Apo AI / HLD表位的多肽，其表达基本上不受脱酰胺的影响。 还描述了使用公开的单克隆抗体和/或所公开的多肽来测定血管液样品中Apo AI的量的诊断系统和方法。
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10.发明授权
公开(公告)号：US4876188A
公开(公告)日：1989-10-24
申请号：US932442
申请日：1986-11-18
CPC分类号： G01N33/723 , Y10S436/808 , Y10S436/811 , Y10S436/815 , Y10S436/825
摘要： Methods of preparing glucitollysinehemoglobin from a sample of glucohemoglobin containing stable and labile glucohemoglobins and for assaying for the presence of stable glucohemoglobin are disclosed, as is a diagnostic assay system useful for carrying out the methods.
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