公开(公告)号：US20070129434A1

公开(公告)日：2007-06-07

申请号：US10501692

申请日：2004-07-15

申请人： Richard Smith-Carliss ,  Frank Caruso ,  Peter Crooks ,  Kenneth Kellar ,  Yingxian Xiao

发明人： Richard Smith-Carliss ,  Frank Caruso ,  Peter Crooks ,  Kenneth Kellar ,  Yingxian Xiao

IPC分类号： A61K31/24

CPC分类号： C07D207/267 ,  A61K31/40 ,  A61K31/44 ,  C07D207/06 ,  C07D207/20 ,  C07D207/22 ,  C07D209/96 ,  C07D401/04

摘要： A method for inducing analgesia and/or inhibiting abuse of abusive substances includes administration of d-methadone metabolites or their structural analogs. The d-methadone metabolites, EMDP and EDDP, and their structural analogs may be incorporated into a suitable pharmaceutical composition for administration to patients. The invention includes the method itself, certain structural analogs, and pharmaceutical compositions for use in accordance with the method.

摘要翻译： 用于诱导镇痛和/或抑制滥用滥用物质的方法包括给予美沙酮代谢物或其结构类似物。 d美沙酮代谢物，EMDP和EDDP及其结构类似物可以并入用于给予患者的合适的药物组合物中。 本发明包括方法本身，某些结构类似物和根据该方法使用的药物组合物。

公开(公告)号：US06423296B1

公开(公告)日：2002-07-23

申请号：US09101528

申请日：1999-02-22

申请人： Wolfgang Gunther ,  Kenneth Kellar ,  Dennis Kiyoshi Fujii ,  Vinay Desai ,  Christopher Black ,  Marshall Beeber ,  Jennifer Wellons ,  Anne Kjersti Fahlvik ,  Jasbir Singh ,  Edward Richard Bacon ,  Gregory Lynn McIntire ,  Robert Alan Snow ,  Brian Weekley ,  Torgrim Engell ,  Michel Gacek ,  David Lee Ladd ,  Anne Naevestad ,  George Na ,  Barbara Yuan ,  Jack Stevens

发明人： Wolfgang Gunther ,  Kenneth Kellar ,  Dennis Kiyoshi Fujii ,  Vinay Desai ,  Christopher Black ,  Marshall Beeber ,  Jennifer Wellons ,  Anne Kjersti Fahlvik ,  Jasbir Singh ,  Edward Richard Bacon ,  Gregory Lynn McIntire ,  Robert Alan Snow ,  Brian Weekley ,  Torgrim Engell ,  Michel Gacek ,  David Lee Ladd ,  Anne Naevestad ,  George Na ,  Barbara Yuan ,  Jack Stevens

IPC分类号： A61B5055

CPC分类号： B82Y5/00 ,  A61K49/049 ,  A61K49/1842 ,  A61K49/186 ,  A61K49/1863

摘要： The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.

摘要翻译： 本发明涉及含有复合纳米颗粒的MR造影剂，优选包含超顺磁性氧化铁芯，其具有包含氧化分解的淀粉涂层的涂层，任选与功能化的聚环氧烷一起延长血液停留。

公开(公告)号：US20060281658A1

公开(公告)日：2006-12-14

申请号：US11147609

申请日：2005-06-08

申请人： Kenneth Kellar ,  Justyna Nicinska

发明人： Kenneth Kellar ,  Justyna Nicinska

IPC分类号： C11D17/00

CPC分类号： C11D3/046 ,  C11D3/10 ,  C11D17/043

摘要： An article comprising an organic solvent free aqueous liquid laundry detergent at least about 35% by weight of water and an inorganic salt, an ionic surfactant, and a non-ionic surfactant which is contained in a package, preferably a pouch or packet containing a unit dose of said liquid laundry detergent, said package comprising a water-soluble film-forming material that dissolves when place in the laundry wash water so as to release the liquid laundry detergent, said water-soluble film-forming material being in substantially direct contact with the liquid laundry detergent, said film-forming material maintaining its structural integrity prior to addition to the laundry wash water due to the critical level of salt contained within the liquid laundry detergent, and wherein said individual pouches are stored within a water vapor impermeable container.

摘要翻译： 包含至少约35重量％水的无机溶剂含水液体衣物洗涤剂和包含在包装中的无机盐，离子表面活性剂和非离子表面活性剂的制品，优选包含单位的袋或包装 所述液体衣物洗涤剂的剂量，所述包装包含水溶性成膜材料，其在衣物洗涤水中的位置时溶解以释放液体衣物洗涤剂，所述水溶性成膜材料基本上直接与 液体衣物洗涤剂，所述成膜材料由于包含在液体衣物洗涤剂中的盐的临界水平而在洗衣洗涤水添加之前保持其结构完整性，并且其中所述单独的袋储存在不透水的容器中。

公开(公告)号：US20060093562A1

公开(公告)日：2006-05-04

申请号：US10981242

申请日：2004-11-04

申请人： Kenneth Kellar ,  Justyna Nicinska

发明人： Kenneth Kellar ,  Justyna Nicinska

IPC分类号： A61K8/21

CPC分类号： A61K8/463 ,  A61K8/19 ,  A61Q11/00

摘要： Sodium decyl sulfate yields high foam production when added to aqueous compositions containing high levels of sodium bicarbonate. Sodium bicarbonate toothpastes and gels containing sodium decyl sulfate have high foaming properties and hold a desirable ribbon-type shape when applied to a toothbrush. Rheological properties and phase stability of such toothpastes can be controlled by the addition of potassium carbonate.

摘要翻译： 当加入含高含量碳酸氢钠的含水组合物中时，癸基硫酸钠会产生高泡沫产量。 碳酸氢钠牙膏和含有十二烷基硫酸钠的凝胶具有高发泡性能，并且当应用于牙刷时保持期望的带状形状。 这种牙膏的流变性能和相稳定性可以通过加入碳酸钾来控制。