公开(公告)号：US06423296B1

公开(公告)日：2002-07-23

申请号：US09101528

申请日：1999-02-22

申请人： Wolfgang Gunther ,  Kenneth Kellar ,  Dennis Kiyoshi Fujii ,  Vinay Desai ,  Christopher Black ,  Marshall Beeber ,  Jennifer Wellons ,  Anne Kjersti Fahlvik ,  Jasbir Singh ,  Edward Richard Bacon ,  Gregory Lynn McIntire ,  Robert Alan Snow ,  Brian Weekley ,  Torgrim Engell ,  Michel Gacek ,  David Lee Ladd ,  Anne Naevestad ,  George Na ,  Barbara Yuan ,  Jack Stevens

发明人： Wolfgang Gunther ,  Kenneth Kellar ,  Dennis Kiyoshi Fujii ,  Vinay Desai ,  Christopher Black ,  Marshall Beeber ,  Jennifer Wellons ,  Anne Kjersti Fahlvik ,  Jasbir Singh ,  Edward Richard Bacon ,  Gregory Lynn McIntire ,  Robert Alan Snow ,  Brian Weekley ,  Torgrim Engell ,  Michel Gacek ,  David Lee Ladd ,  Anne Naevestad ,  George Na ,  Barbara Yuan ,  Jack Stevens

IPC分类号： A61B5055

CPC分类号： B82Y5/00 ,  A61K49/049 ,  A61K49/1842 ,  A61K49/186 ,  A61K49/1863

摘要： The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.

摘要翻译： 本发明涉及含有复合纳米颗粒的MR造影剂，优选包含超顺磁性氧化铁芯，其具有包含氧化分解的淀粉涂层的涂层，任选与功能化的聚环氧烷一起延长血液停留。

公开(公告)号：US5801228A

公开(公告)日：1998-09-01

申请号：US478803

申请日：1995-06-07

申请人： Kenneth Robert Hollister ,  Kenneth Edmund Keller ,  Dong Wei ,  Xin Peng ,  David Lee Ladd ,  Paul Mark Henrichs ,  Robert Allen Snow

发明人： Kenneth Robert Hollister ,  Kenneth Edmund Keller ,  Dong Wei ,  Xin Peng ,  David Lee Ladd ,  Paul Mark Henrichs ,  Robert Allen Snow

IPC分类号： C07D255/02 ,  A61K41/00 ,  A61K49/00 ,  A61K49/08 ,  A61K51/00 ,  A61P39/02 ,  C07D257/02 ,  C07D259/00 ,  C08G63/685 ,  C08G69/48 ,  C07F5/00 ,  C09F13/00

CPC分类号： A61K49/128

摘要： The invention provides polymeric polychelants containing polymer repeat units of formula �L--Ch--L--B! (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic group providing a carbon chain of at least 4 carbon atoms between the L linkages it interconnects) or a salt or chelate thereof, with the proviso that where Ch is 2,5-biscarboxymethyl-2,5-diazahex-1,6-diyl, the polychelant is metallated with lanthanide or manganese ions or B provides a carbon chain of at least 10 carbon atoms between the L linkages it interconnects and their salts and chelates. The paramagnetic polychelates of the polychelants of the invention have remarkably high R.sub.1 relaxivities.

摘要翻译： 本发明提供了含有式[L-Ch-LB]（其中Ch是多齿螯合剂部分）的聚合物重复单元的聚合物聚合物; L是酰胺或酯键; B是提供至少4个碳原子的碳链的疏水基团 在其互连的L键之间）或其盐或螯合物，条件是其中Ch为2,5-双羧甲基-2,5-二氮杂己-1,6-二基，该多孔金属化用镧系元素或锰离子或B 在其互连的L键与其盐和螯合物之间提供至少10个碳原子的碳链。 本发明的聚合物的顺磁性聚合物具有非常高的R1松弛度。

公开(公告)号：US06500917B1

公开(公告)日：2002-12-31

申请号：US09489831

申请日：2000-01-24

申请人： Manohar Tukaram Saindane ,  David Lee Ladd

发明人： Manohar Tukaram Saindane ,  David Lee Ladd

IPC分类号： C08G7902

CPC分类号： C08G65/3353 ,  C07F9/091 ,  C08G65/322

摘要： The invention provides an improved process for the synthesis of compounds carrying at least one phosphate group, especially polyalkylene glycol phosphate compounds, said process comprising the steps of: (a) reacting a compound containing at least one primary alcohol moiety with a diaryl- or diaralkyl-halophosphate whereby to form the corresponding diaryl- or diaralkyl-phosphate ester; (b) reductively cleaving the resulting product; and (c) if desired, repeating steps (a) and (b) with the product of step (b) whereby to produce a compound carrying two or more phosphate groups. Advantages of the process in accordance with the invention are that this avoids the production of by-products and results in products which are low in impurities. Also provided are novel diaryl- and diaralkyl-phosphate ester compounds, in particular polyethylene glycol diphenylphosphate ester and derivatives thereof.

摘要翻译： 本发明提供了一种用于合成携带至少一种磷酸酯基团的化合物，特别是聚亚烷基二醇磷酸酯化合物的改进方法，所述方法包括以下步骤：（a）使含有至少一个伯醇部分的化合物与二芳基或二烷基 从而形成相应的二芳基 - 或二烷基 - 磷酸酯; （b）还原性裂解所得产品; 和（c）如果需要，用步骤（b）的产物重复步骤（a）和（b），由此制备携带两个或更多个磷酸酯基团的化合物。 根据本发明的方法的优点在于，这避免了副产物的生产并导致杂质低的产物。 还提供了新的二芳基 - 和二烷基 - 磷酸酯化合物，特别是聚乙二醇二苯基磷酸酯及其衍生物。