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公开(公告)号：US20110257129A1
公开(公告)日：2011-10-20
申请号：US13152018
申请日：2011-06-02
申请人： Richard Storer , Francois-Rene Alexandre , Cyril Dousson , Adel M. Moussa , Edward Bridges , Alistair Stewart , Jing Yang Wang , Benjamin Alexander Mayes
发明人： Richard Storer , Francois-Rene Alexandre , Cyril Dousson , Adel M. Moussa , Edward Bridges , Alistair Stewart , Jing Yang Wang , Benjamin Alexander Mayes
IPC分类号： A61K31/675 , A61P31/18
CPC分类号： C07F9/5728
摘要： 3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoindole compounds alone or in combination with one or more other anti-viral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
摘要翻译： 提供了基本上为可用于治疗黄病毒科病毒感染，特别是HIV感染的单一对映体形式的3-磷酸吲哚化合物。 还提供了包含单独的3-磷酸吲哚化合物或与一种或多种其它抗病毒剂组合的药物组合物，其制备方法和制备并入这些化合物的药物的方法。
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公开(公告)号：US08486991B2
公开(公告)日：2013-07-16
申请号：US13152018
申请日：2011-06-02
申请人： Richard Storer , Francois-Rene Alexandre , Cyril Dousson , Adel M. Moussa , Edward Bridges , Alistair Stewart , Jing Yang Wang , Benjamin Alexander Mayes
发明人： Richard Storer , Francois-Rene Alexandre , Cyril Dousson , Adel M. Moussa , Edward Bridges , Alistair Stewart , Jing Yang Wang , Benjamin Alexander Mayes
IPC分类号： A61K31/40
CPC分类号： C07F9/5728
摘要： 3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoindole compounds alone or in combination with one or more other anti-viral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
摘要翻译： 提供了基本上为可用于治疗黄病毒科病毒感染，特别是HIV感染的单一对映体形式的3-磷酸吲哚化合物。 还提供了包含单独的3-磷酸吲哚化合物或与一种或多种其它抗病毒剂组合的药物组合物，其制备方法和制备并入这些化合物的药物的方法。
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公开(公告)号：US07960428B2
公开(公告)日：2011-06-14
申请号：US11906095
申请日：2007-09-28
申请人： Richard Storer , Francois-Rene Alexandre , Cyril Dousson , Adel M. Moussa , Edward Bridges , Alistair Stewart , Jing Yang Wang , Benjamin Alexander Mayes
发明人： Richard Storer , Francois-Rene Alexandre , Cyril Dousson , Adel M. Moussa , Edward Bridges , Alistair Stewart , Jing Yang Wang , Benjamin Alexander Mayes
IPC分类号： A61K31/40 , C07D209/42
CPC分类号： C07F9/5728
摘要： 3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoindole compounds alone or in combination with one or more other anti-viral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
摘要翻译： 提供了基本上为可用于治疗黄病毒科病毒感染，特别是HIV感染的单一对映体形式的3-磷酸吲哚化合物。 还提供了包含单独的3-磷酸吲哚化合物或与一种或多种其它抗病毒剂组合的药物组合物，其制备方法和制备并入这些化合物的药物的方法。
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公开(公告)号：US20080213217A1
公开(公告)日：2008-09-04
申请号：US11906095
申请日：2007-09-28
申请人： Richard Storer , Francois-Rene Alexandre , Cyril Dousson , Adel M. Moussa , Edward Bridges , Alistair Stewart , Jing Yang Wang , Benjamin Alexander Mayes
发明人： Richard Storer , Francois-Rene Alexandre , Cyril Dousson , Adel M. Moussa , Edward Bridges , Alistair Stewart , Jing Yang Wang , Benjamin Alexander Mayes
IPC分类号： A61K38/21 , C07D209/04 , C12N5/00 , A61P31/18 , A61K31/675
CPC分类号： C07F9/5728
摘要： 3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoindole compounds alone or in combination with one or more other anti-viral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
摘要翻译： 提供了基本上为可用于治疗黄病毒科病毒感染，特别是HIV感染的单一对映体形式的3-磷酸吲哚化合物。 还提供了包含单独的3-磷酸吲哚化合物或与一种或多种其它抗病毒剂组合的药物组合物，其制备方法和制备并入这些化合物的药物的方法。
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公开(公告)号：US08044091B2
公开(公告)日：2011-10-25
申请号：US12275510
申请日：2008-11-21
CPC分类号： C07F9/65586 , C07F9/5728 , C07F9/65583
摘要： 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
摘要翻译： 描述了用于治疗逆转录病毒感染，特别是HIV的3-磷酸吲哚化合物。 还包括包含单独的3-磷酸吲哚衍生物或与一种或多种其它抗逆转录病毒剂组合的组合物，其制备方法和制备并入这些化合物的药物的方法。
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公开(公告)号：US07534809B2
公开(公告)日：2009-05-19
申请号：US11229150
申请日：2005-09-16
CPC分类号： C07F9/65586 , C07F9/5728 , C07F9/65583
摘要： 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
摘要翻译： 描述了用于治疗逆转录病毒感染，特别是HIV的3-磷酸吲哚化合物。 还包括包含单独的3-磷酸吲哚衍生物或与一种或多种其它抗逆转录病毒剂组合的组合物，其制备方法和制备并入这些化合物的药物的方法。
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公开(公告)号：US20060074054A1
公开(公告)日：2006-04-06
申请号：US11229150
申请日：2005-09-16
IPC分类号： A61K31/675 , C07F9/6561
CPC分类号： C07F9/65586 , C07F9/5728 , C07F9/65583
摘要： 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
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公开(公告)号：US20090163444A1
公开(公告)日：2009-06-25
申请号：US12275510
申请日：2008-11-21
IPC分类号： A61K31/675 , C07F9/572 , A61P31/18
CPC分类号： C07F9/65586 , C07F9/5728 , C07F9/65583
摘要： 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
摘要翻译： 描述了用于治疗逆转录病毒感染，特别是HIV的3-磷酸吲哚化合物。 还包括包含单独的3-磷酸吲哚衍生物或与一种或多种其它抗逆转录病毒剂组合的组合物，其制备方法和制备并入这些化合物的药物的方法。
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公开(公告)号：US07598373B2
公开(公告)日：2009-10-06
申请号：US10735408
申请日：2003-12-12
摘要： The present invention provides an improved process for preparing 2-C-methyl-D-ribonolactone.
摘要翻译： 本发明提供了制备2-C-甲基-D-核糖内酯的改进方法。
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公开(公告)号：US07595390B2
公开(公告)日：2009-09-29
申请号：US10833925
申请日：2004-04-28
申请人： Adel Moussa , Jing Yang Wang , Richard Storer
发明人： Adel Moussa , Jing Yang Wang , Richard Storer
IPC分类号： C07H19/073
CPC分类号： C07H19/073
摘要： An industrially scalable two-step process for preparing a β-L-2′-deoxy-nucleoside that results in a predominance of the β- over the α-anomeric form of the compound is described. An optional third step may be used to prepare 3′-prodrugs of desirable β-L-2′-deoxy-nucleosides for the delivery of these pharmaceuticals effective for treating viral diseases. The synthetic process is applicable in particular to the formation of β-L-2′-deoxy-cytidine, a pharmaceutically acceptable salt or prodrug thereof. The process can provide a relatively uncontaminated product that may require no further isolation or purification, thereby making the synthesis easily scalable for industrial manufacture.
摘要翻译： 描述了一种用于制备β-L-2'-脱氧核苷的工业可扩展的两步法，其导致β-位于化合物的α-端基异构体形式的优势。 可选的第三步可用于制备所需的β-L-2'-脱氧核苷的3'-前药，用于递送有效治疗病毒性疾病的这些药物。 合成方法特别适用于形成β-L-2'-脱氧胞苷，其药学上可接受的盐或前药。 该方法可以提供可能不需要进一步分离或纯化的相对未污染的产品，从而使合成容易扩展到工业制造。
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