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    Isolated nucleic acid molecules which encode mammalian or rodent 2,8 polysialyl transferases
    1.
    发明授权
    Isolated nucleic acid molecules which encode mammalian or rodent 2,8 polysialyl transferases 失效
    编码哺乳动物或啮齿动物2,8聚唾液酸转移酶的分离的核酸分子

    公开(公告)号：US6020201A

    公开(公告)日：2000-02-01

    申请号：US899545

    申请日：1997-07-24

    申请人： Rita Gerardy-Schahn ,  Minoru Fukuda ,  Jun Nakayama ,  Matthias Eckhardt

    发明人： Rita Gerardy-Schahn ,  Minoru Fukuda ,  Jun Nakayama ,  Matthias Eckhardt

    IPC分类号： A61K38/00 ,  C12N9/10 ,  C12N15/00

    CPC分类号： C12N9/1081 ,  A61K38/00

    摘要： A protein having polysialyl transferase activity, which a) is a product of a prokaryotic or eukaryotic expression of an exogenous DNA, b) is coded by the DNA sequence shown in SEQ ID No. 1, c) is coded by the DNA sequences which hybridize with the sequences SEQ ID No. 1 and/or SEQ ID No. 3, d) is coded by DNA sequences which if there was no degeneracy of the genetic code, would hybridize with the sequences defined in b) to c), and e) catalyzes the polycondensation of .alpha.-2,8-linked sialic acids, and its related nucleic acid molecules and fragments are useful for the production of therapeutic agents for tumor therapy.

    摘要翻译： 具有唾液酸转移酶活性的蛋白质，a）是外源DNA的原核或真核表达的产物，b）由SEQ ID No.1所示的DNA序列编码，c）由杂交的DNA序列编码 具有序列SEQ ID No.1和/或SEQ ID No.3，d）由DNA序列编码，如果不存在遗传密码的简并性，将与b）至c）中定义的序列杂交，e ）催化α-2,3-连接的唾液酸的缩聚，其相关的核酸分子和片段可用于生产用于肿瘤治疗的治疗剂。

    Isolated polysialyl transferases
    2.
    发明授权
    Isolated polysialyl transferases 失效
    分离的唾液酸转移酶

    公开(公告)号：US5959078A

    公开(公告)日：1999-09-28

    申请号：US972498

    申请日：1997-11-18

    申请人： Rita Gerardy-Schahn ,  Minoru Fukuda ,  Jun Nakayama ,  Matthias Eckhardt

    发明人： Rita Gerardy-Schahn ,  Minoru Fukuda ,  Jun Nakayama ,  Matthias Eckhardt

    IPC分类号： A61K38/00 ,  C12N9/10 ,  C07K14/00 ,  C12N9/00

    CPC分类号： C12N9/1081 ,  A61K38/00

    摘要： Isolated nucleic acid molecules encoding polysialyl transferases, and the polysialyl transferases themselves are disclosed. SEQ ID NOS: 1, 2, 7 and 8 present examples of these. The nucleic acid molecules and the proteins can be used diagnostically or therapeutically. Additionally, antisense oligonucleotides and antibodies are described, which can also be used diagnostically or therapeutically.

    摘要翻译： 公开了分离的编码聚唾液酸转移酶的核酸分子，以及唾液酸转移酶本身。 图1，图2，图7和图8示出了这些实施例。 核酸分子和蛋白质可以在诊断上或治疗上使用。 另外，描述了反义寡核苷酸和抗体，其也可以在诊断上或治疗上使用。