公开(公告)号：US4577222A

公开(公告)日：1986-03-18

申请号：US444613

申请日：1982-11-26

申请人： Robert A. Kruger ,  James A. Nelson

发明人： Robert A. Kruger ,  James A. Nelson

IPC分类号： A61B6/00 ,  A61B6/02 ,  G06T11/00 ,  H04N5/32

CPC分类号： A61B6/481 ,  A61B6/02 ,  A61B6/504 ,  G06T11/005

摘要： The disclosure is directed to a method and apparatus for generating a processed image of a cross-section through a body. Fluoroscopic tomography is achieved wherein a series of video frames of a cross-section of a body can be viewed in real time. In this manner, for example, one can monitor the progress of a bolus of contrast material moving through a blood vessel in the cross-section being viewed. In a form of the disclosure, a recorded series of frames of a principal plane of a body being imaged can be processed to obtain a corresponding series of frames that represent a plane of interest that is spaced from the principal plane, thereby avoiding the necessity of re-exposure for each new plane to be viewed. In accordance with the disclosed method, a body is disposed between a combination of a source of radiation and an associated detector, such that a beam of radiation from the source impinges angularly on the body and passes through to the detector. Relative rotational motion is effected between the beam and the body, such that a principal plane of interest in the body remains substantially in focus during the relative rotational motion. A series of frames of electronic video signals are derived from the detector, at different rotational positions, the frames representing images of the radiation transmission characteristics of the body at a series of successive times. The series of frames are temporally filtered and then displayed. In a preferred embodiment, the temporal filtering step comprises filtering the series of frames of video signals with a filter function having a temporal frequency response that corresponds substantially the temporal frequency of the movement of a bolus of contrast material through the region being imaged.

摘要翻译： 本公开涉及一种用于通过身体产生横截面的经处理图像的方法和装置。 实现了透视断层摄影，其中可以实时观看身体横截面的一系列视频帧。 以这种方式，例如，可以监视在所观察的横截面中移动通过血管的大量造影剂的进展。 以本公开的形式，可以处理正在成像的身体的主平面的记录的一系列帧，以获得表示与主平面间隔开的感兴趣平面的相应系列的帧，从而避免必要 每次新飞机重新曝光要被观看。 根据所公开的方法，身体设置在辐射源和相关联的检测器的组合之间，使得来自源的辐射束成角度地撞击在身体上并且通过到检测器。 在梁和本体之间进行相对旋转运动，使得在相对旋转运动期间，主体中的感兴趣的主平面保持基本上聚焦。 电子视频信号的一系列帧在不同的旋转位置处从检测器导出，这些帧代表身体在一系列连续时间的辐射传播特性的图像。 一系列帧被时间过滤，然后显示。 在优选实施例中，时间滤波步骤包括用具有时间频率响应的滤波器函数对视频信号的一系列帧进行滤波，该时间频率响应基本上对应于通过所成像的区域的大量对比材料的运动的时间频率。

公开(公告)号：US10472886B2

公开(公告)日：2019-11-12

申请号：US15721515

申请日：2017-09-29

申请人： James A. Nelson

发明人： James A. Nelson

IPC分类号： E06B9/42 ,  E06B9/44 ,  E06B9/72

摘要： The invention is a roller shade tube assembly with a main housing having a lumen divided into two sections by an internal spring stop. The distal end of the main housing has a recessed mounting cavity coupleable to a motor. The proximal end of the main housing has one or more interlocking fingers. A spring inside the proximal lumen abuts the spring stop. An inner guide cylinder is coupled to slide inside the main housing against the spring and coupled to a lumen of an auxiliary housing that is movably coupled to the main housing. The distal end of the auxiliary housing includes one or more complementary interlocking fingers and a second recessed mounting cavity at its proximal end. Wall mounting brackets on each side of the tube assembly are configured to fit into the recessed mounting cavities. A shade fabric is coupled to the roller shade tube assembly.

公开(公告)号：US5071988A

公开(公告)日：1991-12-10

申请号：US661734

申请日：1991-02-27

申请人： Amedeo A. Failli ,  Anthony F. Kreft, III ,  John H. Musser ,  Annette L. Banker ,  James A. Nelson ,  Uresh S. Shah

发明人： Amedeo A. Failli ,  Anthony F. Kreft, III ,  John H. Musser ,  Annette L. Banker ,  James A. Nelson ,  Uresh S. Shah

IPC分类号： C07C45/00 ,  C07C45/63 ,  C07C45/72 ,  C07C59/90 ,  C07C69/738 ,  C07C205/45 ,  C07C255/40 ,  C07D215/14 ,  C07D263/32 ,  C07D413/12

CPC分类号： C07D413/10 ,  C07C205/45 ,  C07C255/40 ,  C07C45/004 ,  C07C45/63 ,  C07C45/72 ,  C07C59/90 ,  C07C69/738 ,  C07D215/14 ,  C07D263/32

摘要： There are disclosed compounds of the formulaA(CH.sub.2).sub.n O--BwhereinA is ##STR1## n is 1-2; B is ##STR2## wherein R.sup.4 and R.sup.5 are each, independently, hydrogen or lower alkyl;R.sup.6 is hydrogen, halo or nitro; ##STR3## R.sup.8 is lower alkyl; m is 0-3;and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated nasobronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

摘要翻译： 公开了式A（CH 2）n O-B的化合物，其中A是n是1-2; B是 ，其中R 4和R 5各自独立地是氢或低级烷基; R6是氢，卤素或硝基; R8是低级烷基; m为0-3; 及其药理学上可接受的盐及其在治疗炎性病症如类风湿性关节炎，溃疡性结肠炎，牛皮癣和其他立即超敏反应中的用途; 治疗白三烯介导的鼻支气管阻塞性通气条件如过敏性鼻炎，过敏性支气管哮喘等; 和作为胃细胞保护剂。

公开(公告)号：USRE33334E

公开(公告)日：1990-09-18

申请号：US259339

申请日：1988-10-18

申请人： James A. Nelson

发明人： James A. Nelson

IPC分类号： B60S3/00 ,  B60S3/06

CPC分类号： B60S3/002 ,  B60S3/06

摘要： An apparatus for both washing and drying an automotive vehicle. The apparatus includes a track gantry that moves along the track and over the vehicle. Water outlets and brushes are on the gantry to wash the car. The apparatus further includes a blower, nozzle, and oscillator. The blower, also mounted on the gantry, expels air onto the vehicle. The nozzle, positioned on the blower, defines an orientation and directs the air from the blower substantially parallel to the orientation. The oscillator periodically changes the orientation of the nozzle and the direction of the air from the blower.

公开(公告)号：US4685169A

公开(公告)日：1987-08-11

申请号：US769666

申请日：1985-08-26

申请人： James A. Nelson

发明人： James A. Nelson

IPC分类号： B60S3/00 ,  B60S3/06

CPC分类号： B60S3/002 ,  B60S3/06 ,  Y10S15/02

摘要： An apparatus for both washing and drying an automotive vehicle. The apparatus includes a track gantry that moves along the track and over the vehicle. Water outlets and brushes are on the gantry to wash the car. The apparatus further includes a blower, nozzle, and oscillator. The blower, also mounted on the gantry, expels air onto the vehicle. The nozzle, positioned on the blower, defines an orientation and directs the air from the blower substantially parallel to the orientation. The oscillator periodically changes the orientation of the nozzle and the direction of the air from the blower.

摘要翻译： 一种用于洗涤和干燥机动车辆的装置。 该装置包括沿轨道和车辆上方移动的轨道台架。 龙门架上的出水口和刷子都要洗车。 该装置还包括鼓风机，喷嘴和振荡器。 也安装在龙门架上的鼓风机将空气排出到车辆上。 定位在鼓风机上的喷嘴限定了取向，并将来自鼓风机的空气基本上平行于取向引导。 振荡器周期性地改变喷嘴的方向和来自鼓风机的空气的方向。

公开(公告)号：US4553960A

公开(公告)日：1985-11-19

申请号：US632956

申请日：1984-07-20

申请人： Harrison Lazarus ,  James A. Nelson

发明人： Harrison Lazarus ,  James A. Nelson

IPC分类号： A61B17/34 ,  A61B19/02 ,  A61M25/01 ,  A61M5/00

CPC分类号： A61B17/3415 ,  A61B50/33 ,  A61M25/0111

摘要： The cannula of a conventional intravascular catheter is placed into the peritoneal cavity through a small shallow incision in antiseptically prepared skin. The stylet or trocar of the conventional catheter is removed; and a stainless steel elongated flexible guide is inserted through the catheter's cannula into the peritoneal cavity. The catheter's cannula is removed and a flexible elongated cannula inserted into the cavity over the guide and secured in place with a suture. Fluid operation means is connected to the elongated cannula by connector means to permit fluid treatment after removal of the guide. Apparatus to effect peritoneal fluid treatment are placed in sterile openable sealed packages for storage and transport.

公开(公告)号：US4479792A

公开(公告)日：1984-10-30

申请号：US423034

申请日：1982-09-24

申请人： Harrison Lazarus ,  James A. Nelson

发明人： Harrison Lazarus ,  James A. Nelson

IPC分类号： A61B17/34 ,  A61B19/02 ,  A61M25/01 ,  A61M25/00

CPC分类号： A61B17/3415 ,  A61B50/33 ,  A61M25/0111

摘要： The cannula of a conventional intravascular catheter is placed into the peritoneal cavity through a small shallow incision in antiseptically prepared skin. The stylet or trocar of the conventional catheter is removed; and a stainless steel elongated flexible guide is inserted through the catheter's cannula into the peritoneal cavity. The catheter's cannula is removed and a flexible elongated cannula inserted into the cavity over the guide and secured in place with a suture. Fluid operation means is connected to the elongated cannula by connector means to permit fluid treatment after removal of the guide. Apparatus to effect peritoneal fluid treatment are placed in sterile openable sealed packages for storage and transport.

摘要翻译： 常规血管内导管的插管通过在防腐剂制备的皮肤中的小的浅切口放入腹腔。 去除常规导管的探针或套管针; 并且将不锈钢细长的柔性引导件穿过导管的插管插入腹膜腔中。 去除导管的套管，并将柔性细长插管插入引导件上的空腔中并用缝合线固定在适当位置。 流体操作装置通过连接器装置连接到细长插管，以在移除引导件之后允许流体处理。 用于进行腹膜液处理的装置放置在用于储存和运输的无菌可打开的密封包装中。

公开(公告)号：US06374670B1

公开(公告)日：2002-04-23

申请号：US08402872

申请日：1995-03-13

申请人： Francis A. Spelman ,  Page Read ,  N. Mani Prakash ,  James A. Nelson ,  Charles E. Pope ,  Margaret Heitkemper ,  James D. Rothermel

发明人： Francis A. Spelman ,  Page Read ,  N. Mani Prakash ,  James A. Nelson ,  Charles E. Pope ,  Margaret Heitkemper ,  James D. Rothermel

IPC分类号： A61B522

CPC分类号： A61B5/42 ,  A61B5/0031 ,  A61B5/06 ,  A61B5/062

摘要： An apparatus (4) and method of non-invasive monitoring of gut motility. An ingestible magnet (10, M) is swallowed by the patient (12) and then linear and rotational movement is directionally detected by an external compass (14, 16). In preferred form, movements of the magnet (10, M) are recorded by a memory means (18) and graphically presented (20) over a period of predetermined time. An alternate embodiment includes multiple compasses (C1, C2) for directionally locating the magnet (10, M) within the patient (12).

摘要翻译： 一种无创性监测肠道运动的装置（4）和方法。 可摄入的磁体（10，M）被患者（12）吞咽，然后线性和旋转运动由外部指南针（14,16）定向检测。 在优选形式中，磁体（10，M）的移动由存储装置（18）记录并在预定时间段内以图形方式呈现（20）。 替代实施例包括用于将患者（12）内的磁体（10，M）定向定位的多个罗盘（C1，C2）。

公开(公告)号：US06372745B1

公开(公告)日：2002-04-16

申请号：US09455220

申请日：1999-12-06

申请人： Annmarie L. Sabb ,  Gregory S. Welmaker ,  James A. Nelson

发明人： Annmarie L. Sabb ,  Gregory S. Welmaker ,  James A. Nelson

IPC分类号： A61K315025

CPC分类号： C07D487/04 ,  A61K31/4985

摘要： This invention provides compounds of formula I, wherein R is hydrogen or alkyl of 1-6 carbon atoms; R′ is hydrogen, alkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl; R1, R2, R3, and R4 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, trifluoroalkyl, —CN, alkyl sulfonamide of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, trifluoroalkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl; X is CR5R6 or a carbonyl group; R5 and R6 are each, independently, hydrogen or alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, with the proviso that at least one of R1, R2, R3, or R4 are not hydrogen; which are 5HT2C receptor agonists useful for the treatment of disorders involving the central nervous system such as obsessive-compulsive disorder, depression, anxiety, schizophrenia, migraine, sleep disorders, eating disorders, obesity, type II diabetes, and epilepsy.

摘要翻译： 本发明提供了式I化合物，其中R是氢或1-6个碳原子的烷基; R'是氢，1-6个碳原子的烷基，2-7个碳原子的酰基或芳酰基; R1，R2，R3， 和R 4各自独立地为氢，1-6个碳原子的烷基，1-6个碳原子的烷氧基，卤素，三氟烷基，-CN，1-6个碳原子的烷基磺酰胺，1-6个碳原子的烷基酰胺， 氨基，1-6个碳原子的烷基氨基，每个烷基部分1-6个碳原子的二烷基氨基，1-6个碳原子的三氟烷氧基，2-7个碳原子的酰基或芳酰基; X是CR5R6或羰基; R5和 R6各自独立地为氢或1-6个碳原子的烷基;或其药学上可接受的盐，条件是R 1，R 2，R 3或R 4中的至少一个不是氢;它们是5HT 2C受体激动剂，其可用于 治疗涉及中枢神经系统的障碍，例如强迫症，抑郁症，焦虑症，精神分裂症，偏头痛，睡眠障碍，进食障碍， 肥胖，II型糖尿病和癫痫。

公开(公告)号：US5824071A

公开(公告)日：1998-10-20

申请号：US798700

申请日：1997-02-12

申请人： James A. Nelson ,  Ascher Shmulewitz

发明人： James A. Nelson ,  Ascher Shmulewitz

IPC分类号： A61B17/00 ,  A61B17/32 ,  A61F2/02 ,  A61F2/06 ,  A61F2/94 ,  A61M25/00 ,  A61M1/10

CPC分类号： A61F2/94 ,  A61B17/320016 ,  A61F2/064 ,  A61F2/2493 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2018/00392 ,  A61F2220/0016 ,  A61M25/0021 ,  A61M25/0075

摘要： Apparatus and methods are provided for use in open surgical and transluminal methods for supplying long-term retrograde perfusion of the myocardium via a conduit disposed between the left ventricle and the coronary sinus. In a first method, an opening is formed between the left ventricle and the coronary sinus, and the coronary ostium is partially occluded using a stent that prevents the pressure in the coronary sinus from exceeding a predetermined value. In an alternative method, a first end of a conduit is inserted transeptally through the right atrium and obliquely into the posterior septal endocardium of the left ventricle via the posterior pyramidal space, while a second end of the conduit is inserted into the coronary sinus via the coronary ostium. A pressure-limiting valve is included in the conduit. In either method, the outlet from the left ventricle to the coronary sinus may include a one-way valve to prevent backflow from the coronary sinus into the left ventricle during cardiac diastole.

摘要翻译： 提供的装置和方法用于通过设置在左心室和冠状窦之间的导管供给心肌的长期逆行灌注的开放式外科和腔内方法。 在第一种方法中，在左心室和冠状窦之间形成开口，并且使用防止冠状窦压力超过预定值的支架部分闭塞冠状口。 在替代方法中，导管的第一端通过右心房横切插入并经由后金字塔形空间倾斜地插入左心室的后隔膜心内膜，而导管的第二端经由 冠状口。 管道中包括一个限压阀。 在任一方法中，从左心室到冠状窦的出口可以包括单向阀，以防止心脏舒张期期间从冠状窦逆流到左心室。