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公开(公告)号：US07371869B2
公开(公告)日：2008-05-13
申请号：US11225950
申请日：2005-09-14
申请人： Robert Alan Goodnow, Jr. , Nicholas J. S. Huby , Norman Kong , Lee Apostle McDermott , John Anthony Moliterni , Zhuming Zhang
发明人： Robert Alan Goodnow, Jr. , Nicholas J. S. Huby , Norman Kong , Lee Apostle McDermott , John Anthony Moliterni , Zhuming Zhang
IPC分类号： A61K31/427 , C07D409/12
CPC分类号： C07D417/14 , C07D417/12
摘要： The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
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公开(公告)号：US07427635B2
公开(公告)日：2008-09-23
申请号：US11202299
申请日：2005-08-11
申请人： Xin-Jie Chu , Nader Fotouhi , Nicholas J. S. Huby , Norman Kong , Lee Apostle McDermott , John Moliterni , Zhuming Zhang
发明人： Xin-Jie Chu , Nader Fotouhi , Nicholas J. S. Huby , Norman Kong , Lee Apostle McDermott , John Moliterni , Zhuming Zhang
IPC分类号： A61K31/427 , C07D417/12
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
摘要翻译： 本发明涉及可用于治疗以MEK多动症为特征的疾病的下式化合物。 因此，该化合物可用于治疗诸如癌症，认知和CNS障碍和炎症/自身免疫性疾病的疾病。
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公开(公告)号：US07612212B2
公开(公告)日：2009-11-03
申请号：US11657800
申请日：2007-01-25
申请人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , Steven Gregory Mischke , John Anthony Moliterni , Hong Wang , Zhuming Zhang
发明人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , Steven Gregory Mischke , John Anthony Moliterni , Hong Wang , Zhuming Zhang
IPC分类号： C07D233/02 , A61K31/4166
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
摘要翻译： 本发明涉及其制备方法的化合物及其使用方法。 该化合物可用于治疗以MEK多动症为特征的疾病。 因此，该化合物可用于治疗诸如癌症，认知和CNS疾病以及炎性/自身免疫性疾病的疾病。
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公开(公告)号：US20070197617A1
公开(公告)日：2007-08-23
申请号：US11657800
申请日：2007-01-25
申请人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , Steven Gregory Mischke , John Anthony Moliterni , Hong Wang , Zhuming Zhang
发明人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , Steven Gregory Mischke , John Anthony Moliterni , Hong Wang , Zhuming Zhang
IPC分类号： A61K31/4178 , A61K31/4166 , C07D403/02
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
摘要翻译： 本发明涉及其制备方法的化合物及其使用方法。 该化合物可用于治疗以MEK多动症为特征的疾病。 因此，该化合物可用于治疗诸如癌症，认知和CNS疾病以及炎性/自身免疫性疾病的疾病。
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公开(公告)号：US08063085B2
公开(公告)日：2011-11-22
申请号：US12331538
申请日：2008-12-10
IPC分类号： A01N43/50 , A61K31/415 , C07D407/00
CPC分类号： C07D233/74 , C07D233/78 , C07D417/14
摘要： The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
摘要翻译： 本发明涉及其制备方法的化合物及其使用方法。 该化合物可用于治疗以MEK多动症为特征的疾病。 因此，该化合物可用于治疗诸如癌症，认知和CNS疾病以及炎性/自身免疫性疾病的疾病。
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公开(公告)号：US07557221B2
公开(公告)日：2009-07-07
申请号：US12186648
申请日：2008-08-06
IPC分类号： A61K31/4184 , C07D403/06
CPC分类号： C07D403/06
摘要： This invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are described in this application. These compounds inhibit the enzymes MEK 1 and MEK2, protein kinases that are components of the MAP kinase signal transduction pathway and as such the compounds will have anti-hyperproliferative cellular activity.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中本申请中描述了R1，R2，R3，R4，R5和R6。 这些化合物抑制作为MAP激酶信号转导途径成分的蛋白激酶MEK1和MEK2，因此这些化合物将具有抗过度增殖的细胞活性。
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公开(公告)号：US08314250B2
公开(公告)日：2012-11-20
申请号：US12905120
申请日：2010-10-15
申请人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
发明人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
IPC分类号： C07D285/01 , C07D417/06 , A61K31/425 , A61K31/4535 , A61K31/4523
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.
摘要翻译： 本发明涉及具有细胞毒活性的根据式1的化合物。 该化合物可用于治疗癌症。
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公开(公告)号：US20110124686A1
公开(公告)日：2011-05-26
申请号：US12905120
申请日：2010-10-15
申请人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
发明人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
IPC分类号： A61K31/454 , A61K31/425 , C07D275/03 , C07D417/06 , A61P35/00
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.
摘要翻译： 本发明涉及具有细胞毒活性的根据式1的化合物。 该化合物可用于治疗癌症。
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公开(公告)号：US20090048452A1
公开(公告)日：2009-02-19
申请号：US12186648
申请日：2008-08-06
IPC分类号： C07D403/06 , C07D409/14
CPC分类号： C07D403/06
摘要： This invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof,wherein R1, R2, R3, R4, R5, and R6 are described in this application. These compounds inhibit the enzymes MEK 1 and MEK2, protein kinases that are components of the MAP kinase signal transduction pathway and as such the compounds will have anti-hyperproliferative cellular activity.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中本申请中描述了R1，R2，R3，R4，R5和R6。 这些化合物抑制作为MAP激酶信号转导途径成分的蛋白激酶MEK1和MEK2，因此这些化合物将具有抗过度增殖的细胞活性。
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公开(公告)号：US20060063814A1
公开(公告)日：2006-03-23
申请号：US11225950
申请日：2005-09-14
申请人： Robert Goodnow, , Nicholas Huby , Norman Kong , Lee McDermott , John Moliterni , Zhuming Zhang
发明人： Robert Goodnow, , Nicholas Huby , Norman Kong , Lee McDermott , John Moliterni , Zhuming Zhang
IPC分类号： A61K31/427 , C07D417/02
CPC分类号： C07D417/14 , C07D417/12
摘要： The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
摘要翻译： 本发明涉及式的化合物
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