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公开(公告)号：US11478795B2
公开(公告)日：2022-10-25
申请号：US16348264
申请日：2017-10-26
申请人： Robert Bosch GmbH
发明人： Bernd Faltin , Jochen Rupp , Juergen Steigert , Christian Dorrer , Karsten Seidl
IPC分类号： C12Q1/6806 , B01L3/00
摘要： A microfluidic device for analysing nucleic acids includes a pump unit with a pumping volume, a filter unit for receiving a lysate, and a reaction chamber. The pump unit, the filter unit and the reaction chamber are arranged in the stated order in a pump direction of the pump unit. The microfluidic device is configured to pump an elution medium via the pump unit into the filter unit for elution and subsequently into the reaction chamber for further treatment.
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公开(公告)号：US20210016289A1
公开(公告)日：2021-01-21
申请号：US16982961
申请日：2019-04-18
申请人： Robert Bosch GmbH
发明人： Jochen Rupp , Daniel Czurratis , Karsten Seidl , Thomas Jelinek
IPC分类号： B01L9/00
摘要： In a device for coupling a cartridge for a lab-on-a-chip analysis device, the cartridge has at least one pneumatic port and at least one reagent chamber. The device has a receiving region and a clamping unit. The receiving region is shaped to receive the cartridge. The clamping unit includes a pneumatic interface for pneumatically contacting the pneumatic port and a punch for insertion into the reagent chamber. The clamping unit is arranged adjacent to the receiving region and is designed to perform a first translatory motion toward the receiving region in order to bring the pneumatic interface into contact with the pneumatic port. Furthermore, the clamping unit is designed to perform a second translatory motion toward the receiving region following the first translatory motion in order to insert the punch into the reagent chamber.
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公开(公告)号：US20200377876A1
公开(公告)日：2020-12-03
申请号：US16603717
申请日：2018-04-05
申请人： Robert Bosch GmbH
发明人： Jochen Rupp , Christian Dorrer , Juergen Steigert , Bernd Faltin , Karsten Seidl
IPC分类号： C12N15/10 , B01L3/00 , C12Q1/6806
摘要： In a method for the desorption of nucleic acids from a sample, in order to simplify the desorption of nucleic acids from the sample, a solid phase is repeatedly rinsed with an elution buffer in a microfluidic system, in order to elute nucleic acids bonded to the solid phase from the solid phase in the microfluidic system.
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公开(公告)号：US20190314818A1
公开(公告)日：2019-10-17
申请号：US16348264
申请日：2017-10-26
申请人： Robert Bosch GmbH
发明人： Bernd Faltin , Jochen Rupp , Juergen Steigert , Christian Dorrer , Karsten Seidl
IPC分类号： B01L3/00 , C12Q1/6806
摘要： A microfluidic device for analysing nucleic acids includes a pump unit with a pumping volume, a filter unit for receiving a lysate, and a reaction chamber. The pump unit, the filter unit and the reaction chamber are arranged in the stated order in a pump direction of the pump unit. The microfluidic device is configured to pump an elution medium via the pump unit into the filter unit for elution and subsequently into the reaction chamber for further treatment.
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5.发明申请公开(公告)号：US20190265259A1
公开(公告)日：2019-08-29
申请号：US16349011
申请日：2017-11-26
申请人： Robert Bosch GmbH
发明人： Martin Schulz , Jochen Rupp , Christian Dorrer , Karsten Seidl
摘要： A processing system includes a processing unit configured to process a cartridge, in particular a microfluidic cartridge, and is further configured to process a biological sample received in the cartridge. The processing unit includes a computing unit configured to compare input or read in sample data with input or read in first cartridge data in order to determine a compatibility of the sample with the cartridge. The computing unit is further configured to output a first error message in response to a determination of incompatibility between the sample and the cartridge. A method includes using the processing system to determine a compatibility between a sample and a cartridge.
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公开(公告)号：USD848637S1
公开(公告)日：2019-05-14
申请号：US29603675
申请日：2017-05-11
申请人： Robert Bosch GmbH
设计人： Martin Schulz , Fabian Baumann , Jochen Rupp , Anette Ströh , Christian Dorrer , Karsten Seidl , Stephan Rein
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公开(公告)号：US10072258B2
公开(公告)日：2018-09-11
申请号：US14910530
申请日：2014-07-30
申请人： Robert Bosch GmbH
发明人： Bernd Faltin , Franz Laermer , Jochen Rupp , Peter Rothacher , Christian Dorrer , Sebastian Berning
CPC分类号： C12N15/1003 , C07H1/06 , C12M47/04 , C12M47/06 , C12N1/06 , C12N1/066 , C12N1/08 , C12N15/1017 , G01N29/00
摘要： A method for preparing a sample of biological materials containing target cells and accompanying cells for extracting nucleic acids of the target cells includes accumulating the target cells of the sample by separating the target cells or the accompanying cells from the sample. The method also includes digesting the target cells via chemical and/or physical lysis in order to produce a target cell lysate containing the nucleic acids of the target cells. The method furthermore includes purifying the nucleic acids from the target cell lysate in order to extract the nucleic acids of the target cells.
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公开(公告)号：US20220252513A1
公开(公告)日：2022-08-11
申请号：US17286339
申请日：2019-10-18
申请人： Robert Bosch GmbH
发明人： Jochen Rupp , Robert Schreiner , Karsten Seidl , Tino Frank , Genrich Siris
摘要： A filter device for an optical module for a lab-on-a-chip analysis device, in which the optical module has a light path, includes a support element, a filter support, and a drive device. The support element can be mounted in the optical module. The filter support is arranged so that it can move on the support element. The filter support also has a first filter region and a second filter region. The drive device is configured such that the filter support can move between a first position in which the first filter region is arranged in the light path, and a second position in which the second filter region is arranged in the light path.
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9.发明申请公开(公告)号：US20210293779A1
公开(公告)日：2021-09-23
申请号：US17047632
申请日：2019-04-18
申请人： Robert Bosch GmbH
发明人： Jochen Rupp , Tom Doehring , Karsten Seidl , Tino Frank
IPC分类号： G01N33/487 , G16H10/40
摘要： A method for actuating an analysis device for running an analysis on a sample material includes reading a user parameter, which represents an analysis to be carried out on the sample material, and loading a plurality of actuation commands for at least one analysis running unit of the analysis device from a command library. The method further includes actuating the at least one analysis running unit using the actuation commands in order to analyze the sample material.
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