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公开(公告)号:US07084145B2
公开(公告)日:2006-08-01
申请号:US10693327
申请日:2003-10-24
申请人: Robert Duncan Armour , Andrew Douglas Baxter , Justin Stephen Bryans , Kevin Neil Dack , Patrick Stephen Johnson , Russell Andrew Lewthwaite , Julie Newman , David James Rawson , Thomas Ryckmans
发明人: Robert Duncan Armour , Andrew Douglas Baxter , Justin Stephen Bryans , Kevin Neil Dack , Patrick Stephen Johnson , Russell Andrew Lewthwaite , Julie Newman , David James Rawson , Thomas Ryckmans
IPC分类号: A61K31/4965 , C07D403/00
CPC分类号: C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/14
摘要: The invention provides compounds of formula (I), the pharmaceutically acceptable salts and solvates thereof, wherein A, B, R1, R2, and R7 are as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereof as vasopressin V1A antagonists.
摘要翻译: 本发明提供式(I)化合物,其药学上可接受的盐和溶剂化物,其中A,B,R 1,R 2和R 7, / SUP>如本文所定义; 其药物组合物; 其组合; 并且其用作血管加压素V 1A拮抗剂。
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公开(公告)号:US07183294B2
公开(公告)日:2007-02-27
申请号:US10800253
申请日:2004-03-12
申请人: Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon John Mantell
发明人: Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon John Mantell
IPC分类号: A61K31/4439 , A61K31/427 , A61K31/4045 , C07D401/12 , C07D209/14
CPC分类号: C07D209/42 , C07D401/12 , C07D417/12
摘要: The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译: 本发明涉及吲哚衍生物和制备用于制备含有这些衍生物的组合物和用途的中间体的方法。 根据本发明的吲哚衍生物可用于许多疾病,病症和病症,特别是炎症,过敏和呼吸道疾病,病症和病症。
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公开(公告)号:US07138527B2
公开(公告)日:2006-11-21
申请号:US10959934
申请日:2004-10-05
申请人: Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon Mantell
发明人: Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon Mantell
IPC分类号: C07D209/04
CPC分类号: C07D209/42
摘要: The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译: 本发明涉及吲哚衍生物和制备用于制备含有这些衍生物的组合物和用途的中间体的方法。 根据本发明的吲哚衍生物可用于许多疾病,病症和病症,特别是炎症,过敏和呼吸道疾病,病症和病症。
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公开(公告)号:US06844362B2
公开(公告)日:2005-01-18
申请号:US10684233
申请日:2003-10-09
申请人: Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon Mantell
发明人: Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon Mantell
IPC分类号: C07D209/42 , A61K31/404 , C07D209/04
CPC分类号: C07D209/42
摘要: The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译: 本发明涉及吲哚衍生物和制备用于制备含有这些衍生物的组合物和用途的中间体的方法。 根据本发明的吲哚衍生物可用于许多疾病,病症和病症,特别是炎症,过敏和呼吸道疾病,病症和病症。
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公开(公告)号:US20120010183A1
公开(公告)日:2012-01-12
申请号:US13179587
申请日:2011-07-11
申请人: Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
发明人: Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
IPC分类号: A61K31/44 , C07D401/04 , C07D215/20 , C07D405/12 , C07D231/56 , A61P29/00 , A61K31/506 , A61K31/47 , A61K31/4427 , A61K31/416 , A61K31/4545 , A61K31/4439 , C07D213/69 , C07D401/12
CPC分类号: C07D213/69 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/56 , C07D239/47 , C07D401/04 , C07D405/12 , C07D487/04
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:或其药学上可接受的盐,其中Het1,X,R1,R2,R3,R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US20130116285A1
公开(公告)日:2013-05-09
申请号:US13808658
申请日:2011-07-06
申请人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Manuel Perez-Pacheco , David James Rawson , Robert Ian Storer , Nigel Alan Swain
发明人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Manuel Perez-Pacheco , David James Rawson , Robert Ian Storer , Nigel Alan Swain
IPC分类号: A61K31/444 , A61K31/4418 , A61K45/06 , A61K31/4164 , C07C311/13 , A61K31/18 , C07D233/64 , C07D213/64 , C07D401/12
CPC分类号: A61K31/444 , A61K31/18 , A61K31/4164 , A61K31/4418 , A61K45/06 , C07C311/13 , C07C311/51 , C07D213/64 , C07D213/65 , C07D213/69 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D401/12
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I):(I) or a pharmaceutically acceptable salt thereof, wherein Z, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式10(I):(I)的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐,其中Z,R1,R2,R3,R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US20120010207A1
公开(公告)日:2012-01-12
申请号:US13179585
申请日:2011-07-11
申请人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
发明人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
IPC分类号: A61K31/18 , C07D231/12 , C07D233/64 , A61P29/00 , A61K31/415 , A61K31/4164 , A61K31/50 , A61K31/277 , C07C311/51 , C07D237/08
CPC分类号: C07C311/51 , C07C2601/02 , C07D231/12 , C07D233/60 , C07D237/08
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:或其药学上可接受的盐,其中Ar1,X,R1,R2,R3,R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US08592629B2
公开(公告)日:2013-11-26
申请号:US13179587
申请日:2011-07-11
申请人: Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
发明人: Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
IPC分类号: C07C303/00 , A61K31/18
CPC分类号: C07D213/69 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/56 , C07D239/47 , C07D401/04 , C07D405/12 , C07D487/04
摘要: This invention relates to sulfonamide derivative of formula (I), to their use in medicine, to compositions containing them, to processes for their preparation, and to intermediates used in such processes. These compounds are inhibitors of Nav1.7.
摘要翻译: 本发明涉及式(I)的磺酰胺衍生物,其在药物中的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 这些化合物是Nav1.7的抑制剂。
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公开(公告)号:US08685977B2
公开(公告)日:2014-04-01
申请号:US13179585
申请日:2011-07-11
申请人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
发明人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
IPC分类号: A01N43/58 , A61K31/50 , A01N43/40 , A61K31/435 , A01N43/56 , A61K31/415 , A01N43/36 , A61K31/40
CPC分类号: C07C311/51 , C07C2601/02 , C07D231/12 , C07D233/60 , C07D237/08
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:或其药学上可接受的盐,其中Ar1,X,R1,R2,R3,R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US08772343B2
公开(公告)日:2014-07-08
申请号:US13808658
申请日:2011-07-06
申请人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Manuel Perez-Pacheco , David James Rawson , Robert Ian Storer , Nigel Alan Swain
发明人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Manuel Perez-Pacheco , David James Rawson , Robert Ian Storer , Nigel Alan Swain
IPC分类号: A01N41/06 , A61K31/18 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00
CPC分类号: A61K31/444 , A61K31/18 , A61K31/4164 , A61K31/4418 , A61K45/06 , C07C311/13 , C07C311/51 , C07D213/64 , C07D213/65 , C07D213/69 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D401/12
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I):(I) or a pharmaceutically acceptable salt thereof, wherein Z, R1, R2, R3, R4 and R5 are as defined in the description. Nav1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式10(I):(I)的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐,其中Z,R1,R2,R3,R4和R5如说明书中所定义。 Nav1.7抑制剂可用于治疗各种各样的疾病,特别是疼痛。
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