公开(公告)号：US08988372B2

公开(公告)日：2015-03-24

申请号：US13402452

申请日：2012-02-22

Applicant: Robert G. Messerschmidt ,  Christopher D. Brown

Inventor： Robert G. Messerschmidt ,  Christopher D. Brown

IPC: G09G3/36 ,  G06F3/041 ,  G06F19/00

CPC classification number: A61B5/02427 ,  A61B5/0404 ,  A61B5/0537 ,  A61B5/6898 ,  G06F3/041 ,  G06F19/00 ,  G09G3/36 ,  G16H40/63

Abstract: An apparatus and method for obtaining a physiological measurement associated with a user using a portable device is disclosed herein. Information displayed on a touch-sensitive display of the portable device specifies the contact area(s) on the portable device for a user to touch. One or more areas on the portable device and/or a detachable device connected to the portable device comprise conductive areas for measuring the resistance or impedance of the user's body between those conductive areas.

Abstract translation: 本文公开了一种用于使用便携式设备获得与用户相关联的生理测量的装置和方法。 在便携式设备的触敏显示器上显示的信息指定便携式设备上的用户触摸的接触区域。 便携式设备上的一个或多个区域和/或连接到便携式设备的可拆卸设备包括用于测量用户身体在那些导电区域之间的电阻或阻抗的导电区域。

公开(公告)号：US06622032B1

公开(公告)日：2003-09-16

申请号：US09672373

申请日：2000-09-28

Applicant: Mark Ries Robinson ,  Robert G. Messerschmidt

Inventor： Mark Ries Robinson ,  Robert G. Messerschmidt

IPC: A61B550

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2562/146

Abstract: A method for non-invasively measuring the concentration of an analyte, particularly blood analyte in blood. The method utilizes spectrographic techniques in conjunction with an improved optical interface between a sensor probe and a skin surface or tissue surface of the body containing the blood to be analyzed. An index-matching medium is disclosed to improve the interface between the sensor probe and skin surface during spectrographic analysis. In a preferred embodiment, the blood analyte concentration in blood is quantified utilizing a partial squares analysis relative to a model incorporating analysis of plural known blood samples.

Abstract translation: 用于非侵入性地测量血液中分析物，特别是血液分析物浓度的方法。 该方法利用光谱技术结合传感器探针与包含待分析血液的皮肤表面或组织表面之间的改进的光学界面。 公开了一种索引匹配介质，以在光谱分析期间改善传感器探针和皮肤表面之间的界面。 在优选实施方案中，使用相对于包含多个已知血液样品分析的模型的部分平方分析来定量血液中的血液分析物浓度。

公开(公告)号：US06230034B1

公开(公告)日：2001-05-08

申请号：US09324286

申请日：1999-06-02

Applicant: Robert G. Messerschmidt ,  Mark Ries Robinson

Inventor： Robert G. Messerschmidt ,  Mark Ries Robinson

IPC: A61B500

CPC classification number: G01N21/474 ,  G01N21/4738 ,  G01N21/49

Abstract: An improved method and apparatus for diffuse reflectance spectroscopy. A specular control device is provided that can discriminate between diffusely reflected light that is reflected from selected depths or layers within the tissue. The specular control device permits a spectroscopic analyzer to receive the diffusely reflected light that is reflected from, for example, a first layer or depth within the tissue, while preventing the remaining diffusely reflected light from reaching the spectroscopic analyzer. Furthermore, the specular control device may prevent the specularly reflected light (e.g. surface reflected light) from reaching the spectroscopic analyzer.

Abstract translation: 一种用于漫反射光谱的改进方法和装置。 提供了一种镜面控制装置，其可以区分从组织内的选定深度或层反射的漫反射光。 镜面控制装置允许光谱分析仪接收从例如组织内的第一层或深度反射的漫反射光，同时防止剩余的漫反射光到达光谱分析仪。 此外，镜面控制装置可以防止镜面反射光（例如表面反射光）到达光谱分析仪。

公开(公告)号：US5935062A

公开(公告)日：1999-08-10

申请号：US871366

申请日：1997-06-09

Applicant: Robert G. Messerschmidt ,  Mark Ries Robinson

Inventor： Robert G. Messerschmidt ,  Mark Ries Robinson

IPC: G01N21/35 ,  G01N21/47 ,  G01N21/49 ,  A61B5/00

CPC classification number: G01N21/474 ,  G01N21/4738 ,  G01N21/49

Abstract: An improved method and apparatus for diffuse reflectance spectroscopy. A specular control device is provided that can discriminate between diffusely reflected light that is reflected from selected depths or layers within the tissue. The specular control device permits a spectroscopic analyzer to receive the diffusely reflected light that is reflected from, for example, a first layer or depth within the tissue, while preventing the remaining diffusely reflected light from reaching the spectroscopic analyzer. Furthermore, the specular control device may prevent the specularly reflected light (e.g. surface reflected light) from reaching the spectroscopic analyzer.

公开(公告)号：US5823951A

公开(公告)日：1998-10-20

申请号：US844501

申请日：1997-04-18

Applicant: Robert G. Messerschmidt

Inventor： Robert G. Messerschmidt

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2562/146 ,  A61B5/1495 ,  Y10S514/937

Abstract: A method for non-invasively measuring the concentration of an analyte, particularly blood analyte in blood. The method utilizes spectrographic techniques in conjunction with an improved optical interface between a sensor probe and a skin surface or tissue surface of the body containing the blood to be analyzed. An index-matching medium is disclosed to improve the interface between the sensor probe and skin surface during spectrographic analysis. In a preferred embodiment, the blood analyte concentration in blood is quantified utilizing a partial squares analysis relative to a model incorporating analysis of plural known blood samples.

公开(公告)号：US5019715A

公开(公告)日：1991-05-28

申请号：US487550

申请日：1990-03-02

Applicant: Donald W. Sting ,  Robert G. Messerschmidt ,  John A. Reffner

Inventor： Donald W. Sting ,  Robert G. Messerschmidt ,  John A. Reffner

IPC: G01J3/42 ,  G01N21/27 ,  G01N21/47 ,  G01N21/55 ,  G02B21/00

CPC classification number: G01N21/4738 ,  G01N21/55

Abstract: An optical system, apparatus and method for analyzing samples includes a radiant energy source, a first mask, a first mirror system, a sample plane, a second mirror system, a second mask and a detector. The first and second masks are respectively positioned along the optical path of the system in the same or different Fourier planes and/or conjugate planes thereof. The first mask has at least one inlet aperture with the relative position thereof in the first mask determining the angle of the energy incidence onto the sample. The second mask has at least one outlet aperture therein passing radiant energy therethrough which has been reflected from or transmitted through the sample at a preselected angle determined by the relative position of the second aperture in the second mask. Numerous first and second masks respectively having inlet and outlet apertures at different radial and/or circumferential positions may be used in the optical system to perform many types of analyses without moving or specially preparing the sample.

Abstract translation: 用于分析样本的光学系统，装置和方法包括辐射能量源，第一掩模，第一反射镜系统，样品平面，第二反射镜系统，第二掩模和检测器。 第一和第二掩模分别沿着相同或不同的傅立叶平面和/或共轭平面的系统的光路定位。 第一掩模具有至少一个入口孔，其中在第一掩模中的相对位置确定能量入射到样品上的角度。 第二掩模具有至少一个出口孔，其中穿过其中的辐射能，其已经以由第二掩模中的第二孔的相对位置确定的预选角度反射或透射通过样品。 在光学系统中可以使用分别具有在不同径向和/或周向位置处的入口和出口孔的许多第一和第二掩模，以执行许多类型的分析，而不移动或特别准备样品。

公开(公告)号：US4712912A

公开(公告)日：1987-12-15

申请号：US837672

申请日：1986-03-10

Applicant: Robert G. Messerschmidt

Inventor： Robert G. Messerschmidt

IPC: G01J3/02 ,  G01N21/25 ,  G01N21/55 ,  G01N21/59

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01N21/474 ,  G01N2201/0806

Abstract: The optical system of the present invention comtemplates directing a beam of radiant energy to either an aperture beam splitter or polarizing beam splitter. Radiant energy from the beam splitter forms a first remote image at an entrance to an image scrambler so that any image information which the beam contains is destroyed. The output of the scrambler fills the full aperture of a focusing objective that reproduces the image of the output of the scrambler onto a sample. A mask, positioned at a remote image between the output of the scrambler and focusing objective, determines the geometrical shape of the sample image. The focusing objective images the radiant energy that is reflected from the sample to a second remote image at the scrambler so that the scrambler destroys image information while retaining spectroscopic information. The beam splitter reflects a portion of the radiant energy from the scrambler to the detector. The absence of image information in the radiant energy from the sample reduces measurement errors by producing a predictable dispersion of radiant energy at the detector.

Abstract translation: 本发明的光学系统旨在将辐射能束照射到孔径分束器或偏振分束器。 来自分束器的辐射能量在图像加扰器的入口处形成第一远程图像，使得束包含的任何图像信息被破坏。 加扰器的输出填充聚焦目标的全孔径，其将扰频器的输出的图像再现到样本上。 位于加扰器的输出端和聚焦目标之间的远程图像处的掩模确定样本图像的几何形状。 聚焦目标将从样本反射的辐射能量图像化成加扰器处的第二远程图像，使得加扰器在保留光谱信息的同时破坏图像信息。 分束器将辐射能量的一部分从扰频器反射到检测器。 来自样品的辐射能中不存在图像信息通过在检测器处产生可预测的辐射能的色散来降低测量误差。

公开(公告)号：US20140051939A1

公开(公告)日：2014-02-20

申请号：US13588884

申请日：2012-08-17

Applicant: Robert G. Messerschmidt

Inventor： Robert G. Messerschmidt

IPC: A61B5/0205 ,  A61B5/0215 ,  A61B5/053 ,  A61B5/01 ,  A61B5/042 ,  A61B5/103 ,  A61B5/00 ,  A61B5/024

CPC classification number: A61B5/6817 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/02438 ,  A61B5/02444 ,  A61B5/0404

Abstract: An apparatus and method for obtaining one or more physiological measurements associated with a user using ear-located sensors is disclosed herein. One or more of different types of sensors are configured to engage a user's ear. In some cases, the sensors will be included in one or both of a pair of earphones to capture physiological parameters. A portable device is configured to be in communication with the earphones to receive physiological parameters from the sensor(s) therein, and to potentially provide control signals to the sensors or other components in the earphones. The portable device determines physiological measurements corresponding to the received physiological parameters. The portable device is also configured to provide a user interface to interact with the user regarding the physiological measurements.

Abstract translation: 本文公开了一种用于使用耳位传感器获得与用户相关联的一个或多个生理测量的装置和方法。 一种或多种不同类型的传感器被配置成接合用户的耳朵。 在一些情况下，传感器将被包括在一对耳机中的一个或两个中以捕获生理参数。 便携式设备被配置为与耳机通信以从其中的传感器接收生理参数，并且潜在地向耳机中的传感器或其他部件提供控制信号。 便携式装置确定对应于所接收的生理参数的生理测量。 便携式设备还被配置为提供用户接口与生理测量相关联的用户界面。

公开(公告)号：US20130215042A1

公开(公告)日：2013-08-22

申请号：US13402452

申请日：2012-02-22

Applicant: Robert G. Messerschmidt ,  Christopher D. Brown

Inventor： Robert G. Messerschmidt ,  Christopher D. Brown

IPC: G09G3/36 ,  G06F3/041

CPC classification number: A61B5/02427 ,  A61B5/0404 ,  A61B5/0537 ,  A61B5/6898 ,  G06F3/041 ,  G06F19/00 ,  G09G3/36 ,  G16H40/63

Abstract: An apparatus and method for obtaining a physiological measurement associated with a user using a portable device is disclosed herein. Information displayed on a touch-sensitive display of the portable device specifies the contact area(s) on the portable device for a user to touch. One or more areas on the portable device and/or a detachable device connected to the portable device comprise conductive areas for measuring the resistance or impedance of the user's body between those conductive areas.

公开(公告)号：US20110001965A1

公开(公告)日：2011-01-06

申请号：US12865698

申请日：2009-01-30

Applicant: Robert G. Messerschmidt

Inventor： Robert G. Messerschmidt

IPC: G01J3/42

CPC classification number: G01N21/552 ,  G01N21/43 ,  G01N2201/0221

Abstract: Spectroscopy apparatuses oriented to the critical angle of the sample are described that detecting the spectral characteristics of a sample wherein the apparatus consists of an electromagnetic radiation source adapted to excite a sample with electromagnetic radiation introduced to the sample at an angle of incidence at or near a critical angle of the sample; a transmitting crystal in communication with the electromagnetic radiation source and the sample, the transmitting crystal having a high refractive index adapted to reflect the electromagnetic radiation internally; a reflector adapted to introduce the electromagnetic radiation to the sample at or near an angle of incidence near the critical angle between the transmitting crystal and sample; and a detector for detecting the electromagnetic radiation from the sample. Also, provided herein are methods, systems, and kits incorporating the peri-critical reflectance spectroscopy apparatus.

Abstract translation: 描述了以样品的临界角取向的光谱装置，其检测样品的光谱特性，其中该装置由电磁辐射源组成，该电磁辐射源适用于以在入射角处或附近的入射角引入样品的电磁辐射 样品的临界角; 与电磁辐射源和样品通信的透射晶体，透射晶体具有适于在内部反射电磁辐射的高折射率; 反射器，其适于将电磁辐射引入接近接近发射晶体和样品之间的临界角的入射角; 以及用于检测来自样品的电磁辐射的检测器。 此外，本文提供了包含周边反射光谱仪的方法，系统和试剂盒。