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    Pseudo-thermosetting neutralized chitosan composition forming a hydrogel and a process for producing the same
    5.
    发明授权
    Pseudo-thermosetting neutralized chitosan composition forming a hydrogel and a process for producing the same 失效
    形成水凝胶的假热固化中和的壳聚糖组合物及其制备方法

    公开(公告)号：US08507563B2

    公开(公告)日：2013-08-13

    申请号：US12654700

    申请日：2009-12-29

    申请人： Jérôme Berger ,  Robert Gurny ,  Marianne Reist Oechslin

    发明人： Jérôme Berger ,  Robert Gurny ,  Marianne Reist Oechslin

    IPC分类号： A61K47/00

    CPC分类号： C08J3/075 ,  A61K9/06 ,  A61K47/36 ,  C08J2305/08

    摘要： The composition disclosed is a pseudo-thermosetting neutralized chitosan composition, neutralized with a hydroxylated base, forming a phosphate-free transparent hydrogel at a temperature higher than 5° C. Said composition contains a homogeneously reacetylated chitosan derived from a chitosan having a deacetylation degree of 80-90%, having a molecular weight of not smaller than 200 kDa and a deacetylation degree of 30-60%, and may further contain a diol. Said composition may be used as a drug delivery system.

    摘要翻译： 所公开的组合物是用羟基化碱中和的假热固性中和的壳聚糖组合物，在高于5℃的温度下形成无磷酸盐的透明水凝胶。所述组合物含有衍生自具有脱乙酰度的壳聚糖的均匀重新乙酰化壳聚糖 80-90％，分子量不小于200kDa，脱乙酰度为30-60％，还可以含有二醇。 所述组合物可用作药物递送系统。

    Bioadhesive ophthalmic insert
    7.
    发明授权
    Bioadhesive ophthalmic insert 失效
    生物粘合剂眼科插入物

    公开(公告)号：US5773021A

    公开(公告)日：1998-06-30

    申请号：US751561

    申请日：1996-11-18

    申请人： Florian Gurtler ,  Robert Gurny

    发明人： Florian Gurtler ,  Robert Gurny

    IPC分类号： A61K9/00 ,  A61F2/00

    CPC分类号： A61K9/0051

    摘要： A bioadhesive ophthalmic insert is described which is intended more particularly for the prolonged and controlled release of a medicinal substance. The insert comprises a composite polymeric material matrix in which the medicinal substance is incorporated. The composite polymeric material matrix comprises a water-soluble biocompatible polymer and a bioadhesive biocompatible polymer and, where applicable, a water-insoluble biocompatible polymer.

    摘要翻译： 描述了一种生物粘合剂眼科插入物，其特别用于延长和控制释放药物。 插入物包括其中掺入药物的复合聚合材料基质。 复合聚合材料基质包含水溶性生物相容性聚合物和生物粘附生物相容性聚合物，并且在适用的情况下包含水不溶性生物相容性聚合物。

    INTRAOCULAR LENS WITH DRUG DELIVERY SYSTEM ATTACHED THERETO
    10.
    发明申请
    INTRAOCULAR LENS WITH DRUG DELIVERY SYSTEM ATTACHED THERETO 审中-公开
    带有附带药物输送系统的内窥镜

    公开(公告)号：US20090130176A1

    公开(公告)日：2009-05-21

    申请号：US12295570

    申请日：2007-03-29

    申请人： Leila Bossy-Nobs ,  Olivia Felt-Baeyens ,  Robert Gurny ,  Simone Eperon ,  Yan Guex-Crosier

    发明人： Leila Bossy-Nobs ,  Olivia Felt-Baeyens ,  Robert Gurny ,  Simone Eperon ,  Yan Guex-Crosier

    IPC分类号： A61K9/00 ,  A61P27/02 ,  A61K31/58

    CPC分类号： A61F9/0017 ,  A61F2/16 ,  A61F2002/1681 ,  A61F2250/0067 ,  A61K9/0048 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2430/16

    摘要： The present invention relates to a device comprising an intraocular lens and a drug delivery system attached thereto, wherein said drug delivery system is or can be loaded with one or more therapeutic agents. Preferably, said drug delivery system comprises a biodegradable matrix material wherein said biodegradable matrix material is preferably selected from the group consisting of: poly(lactic acid), poly(glycolic acid), poly(lactide-co-glycolide), polycaprolactones, polyorthoesters, polyanhydrides, polyesteramides and mixtures thereof. Preferred therapeutic agent(s) is/are selected from anti-inflammatory agents, anti-vasoproliferative agents, immunosuppressive agents, antibiotics, antiviral agents, anti-mitotic agents and combinations thereof. Also provided is a method of treatment and/or prevention of one or more diseases or malfunctions of the eye, comprising implanting one, two, three or more devices of the invention into an eye of a patient.

    摘要翻译： 本发明涉及包含眼内透镜和附着于其上的药物递送系统的装置，其中所述药物递送系统是或可以装载一种或多种治疗剂。 优选地，所述药物递送系统包括可生物降解的基质材料，其中所述可生物降解的基质材料优选选自：聚（乳酸），聚（乙醇酸），聚（丙交酯 - 共 - 乙交酯），聚己内酯，聚原酸酯， 聚酐，聚酯酰胺及其混合物。 优选的治疗剂选自抗炎剂，抗血管增生剂，免疫抑制剂，抗生素，抗病毒剂，抗有丝分裂剂及其组合。 还提供了治疗和/或预防一种或多种疾病或眼睛功能障碍的方法，包括将本发明的一种，两种，三种或更多种装置植入患者的眼睛。