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    Method of mass spectrometry and a mass spectrometer
    1.
    发明授权
    Method of mass spectrometry and a mass spectrometer 有权
    质谱法和质谱仪

    公开(公告)号：US06982414B2

    公开(公告)日：2006-01-03

    申请号：US10464513

    申请日：2003-06-19

    申请人： Robert Harold Bateman ,  James Ian Langridge ,  Therese McKenna ,  Keith Richardson

    发明人： Robert Harold Bateman ,  James Ian Langridge ,  Therese McKenna ,  Keith Richardson

    IPC分类号： B01D59/44

    CPC分类号： H01J49/0031 ,  H01J49/0027 ,  H01J49/0045 ,  H01J49/10 ,  H01J49/34

    摘要： A method of mass spectrometry is disclosed wherein a gas collision cell is repeatedly switched between a fragmentation and a non-fragmentation mode. Parent ions from a first sample are passed through the collision cell and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the collision cell and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples.

    摘要翻译： 公开了一种质谱法，其中气体碰撞池在分段和非碎裂模式之间重复切换。 来自第一个样品的亲本离子通过碰撞池，并获得亲本离子质谱和碎裂离子质谱。 然后将来自第二个样品的亲本离子通过碰撞池，并获得第二组母体离子质谱和碎片离子质谱。 然后比较质谱，并且如果两个样品中的某些亲本离子或某些断裂离子不同地表达，则进行进一步分析以寻找在两个不同样品中不同表达的离子。

    Mass spectrometer
    4.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US06992283B2

    公开(公告)日：2006-01-31

    申请号：US10739041

    申请日：2003-12-19

    申请人： Robert Harold Bateman ,  John Brian Hoyes ,  James Ian Langridge ,  Jason Lee Wildgoose

    发明人： Robert Harold Bateman ,  John Brian Hoyes ,  James Ian Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/00

    CPC分类号： H01J49/40 ,  G01N27/622 ,  H01J49/0036 ,  H01J49/004

    摘要： A mass spectrometer is disclosed wherein ions are passed through an ion mobility separator and are then mass analysed by a Time of Flight mass analyzer. Multiple sets of mass spectral data are obtained which are then post-processed so that mass spectral data relating to ions having undesired charge state(s) is filtered out. The resultant mass spectrum comprises ions having a desired charge state.

    摘要翻译： 公开了一种质谱仪，其中离子通过离子迁移率分离器，然后通过飞行时间质量分析仪进行质量分析。 获得多组质谱数据，然后对其进行后处理，从而滤出与具有不期望的电荷状态的离子相关的质谱数据。 所得质谱包括具有所需电荷状态的离子。