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公开(公告)号:US20070038144A1
公开(公告)日:2007-02-15
申请号:US11463346
申请日:2006-08-09
申请人: Robert Hughes , Timothy Dietz , Michael Andreyko , Kent Swendseid , Jay Wilkins , William Clem
发明人: Robert Hughes , Timothy Dietz , Michael Andreyko , Kent Swendseid , Jay Wilkins , William Clem
IPC分类号: A61B10/00
CPC分类号: A61B10/02 , A61B5/055 , A61B5/0555 , A61B10/0041 , A61B10/0233 , A61B10/0275 , A61B10/0283 , A61B17/3403 , A61B17/3417 , A61B17/3421 , A61B90/11 , A61B90/17 , A61B2010/0208 , A61B2010/0225 , A61B2017/00477 , A61B2017/00796 , A61B2017/00911 , A61B2017/3411 , A61B2090/034 , A61B2090/036 , A61B2090/374 , A61B2090/3908 , A61B2090/3933 , A61B2090/3954 , A61B2090/3987
摘要: A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and, in particular, a sleeve to a biopsy site of suspicious tissues or lesions. A z-stop enhances accurate insertion, prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imagability, to enhance vacuum and pressure assist therethrough, etc.
摘要翻译: 定位机构或夹具与乳房线圈一起用于乳房压缩,并用于在开放和闭合的磁共振成像(MRI)机器中的易行活检过程中引导核心活检仪器。 定位夹具包括用于支撑和定向MRI兼容的活检器具的三维笛卡尔定位引导件,并且特别地,将套筒连接到可疑组织或病变的活检部位。 Z形止动器可提高精确插入,防止套筒过度插入或意外收回。 袖子接受MRI兼容的活检仪器的探针,并且可以包含各种特征以增强其成像能力,以增强真空和压力辅助等。
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公开(公告)号:US20050283069A1
公开(公告)日:2005-12-22
申请号:US11103959
申请日:2005-04-12
申请人: Robert Hughes , Timothy Dietz , Michael Andreyko , Kent Swendseid , Jay Wilkins , William Clem
发明人: Robert Hughes , Timothy Dietz , Michael Andreyko , Kent Swendseid , Jay Wilkins , William Clem
CPC分类号: A61B10/02 , A61B5/055 , A61B5/0555 , A61B10/0041 , A61B10/0233 , A61B10/0275 , A61B10/0283 , A61B17/3403 , A61B17/3417 , A61B17/3421 , A61B90/11 , A61B90/17 , A61B2010/0208 , A61B2010/0225 , A61B2017/00477 , A61B2017/00796 , A61B2017/00911 , A61B2017/3411 , A61B2090/034 , A61B2090/036 , A61B2090/374 , A61B2090/3908 , A61B2090/3933 , A61B2090/3954 , A61B2090/3987
摘要: A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and, in particular, a sleeve to a biopsy site of suspicious tissues or lesions. A z-stop enhances accurate insertion, prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imagability, to enhance vacuum and pressure assist therethrough, etc.
摘要翻译: 定位机构或夹具与乳房线圈一起用于乳房压缩,并用于在开放和闭合的磁共振成像(MRI)机器中的易行活检过程中引导核心活检仪器。 定位固定器包括用于支撑和定向MRI兼容的活检器具的三维笛卡尔定位引导件,特别是将套筒连接到可疑组织或病变的活检部位。 Z形止动器可提高精确插入,防止套筒过度插入或意外收回。 袖子接受MRI兼容的活检仪器的探针,并且可以包含各种特征以增强其成像能力,以增强真空和压力辅助等。
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公开(公告)号:US20050261581A1
公开(公告)日:2005-11-24
申请号:US11076612
申请日:2005-03-10
申请人: Robert Hughes , Timothy Dietz , Michael Andreyko , William Clem , Martin Albini
发明人: Robert Hughes , Timothy Dietz , Michael Andreyko , William Clem , Martin Albini
CPC分类号: A61B10/02 , A61B5/055 , A61B5/0555 , A61B10/0041 , A61B10/0233 , A61B10/0275 , A61B10/0283 , A61B17/3403 , A61B17/3417 , A61B17/3421 , A61B90/11 , A61B90/17 , A61B2010/0208 , A61B2010/0225 , A61B2017/00477 , A61B2017/00796 , A61B2017/00911 , A61B2017/3411 , A61B2090/034 , A61B2090/036 , A61B2090/374 , A61B2090/3908 , A61B2090/3933 , A61B2090/3954 , A61B2090/3987
摘要: A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and in particular a sleeve, to a biopsy site of suspicious tissues or lesions. A depth stop enhances accurate insertion, prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imagability, to enhance vacuum and pressure assist therethrough, etc.
摘要翻译: 定位机构或夹具与乳房线圈一起用于乳房压缩,并用于在开放和闭合的磁共振成像(MRI)机器中的易行活检过程中引导核心活检仪器。 定位固定装置包括一个三维笛卡尔定位指南,用于支持和定向MRI兼容的活检仪器,特别是套筒,用于可疑组织或病变的活检部位。 深度限位器可提高精确插入,防止套筒过度插入或意外收回。 袖子接受MRI兼容的活检仪器的探针,并且可以包含各种特征以增强其成像能力,以增强真空和压力辅助等。
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公开(公告)号:US20070167736A1
公开(公告)日:2007-07-19
申请号:US11323535
申请日:2005-12-30
申请人: Timothy Dietz , Keshava Datta , John Hibner , Michael Murray , Robert Hughes
发明人: Timothy Dietz , Keshava Datta , John Hibner , Michael Murray , Robert Hughes
IPC分类号: A61B5/05
CPC分类号: G01R33/286 , A61B5/05 , A61B5/055 , A61B10/0041 , A61B10/0275 , A61B90/11 , A61B2010/045 , A61B2090/374 , A61B2090/3908 , A61B2090/3954 , A61B2090/3983
摘要: An obturator as part of a biopsy system enhances use with Magnetic Resonance Imaging (MRI) by indicating location of a side aperture in an encompassing cannula. The cannula (e.g., detached probe, sleeve sized to receive a core biopsy probe) includes a side aperture for taking a tissue sample. When the obturator is inserted in lieu of the biopsy device into the cannula, a notch formed in a shaft of the obturator corresponds to the side aperture. A dugout trough into the notch may further accept aqueous material to further accentuate the side aperture. In addition, a series of dimensionally varied apertures (e.g., wells, slats) that communicate through a lateral surface of the shaft and that are proximal to the side aperture receive an aqueous material to accentuate visibility in an MRI image, even in a skewed MRI slice through the cannula/obturator.
摘要翻译: 作为活检系统的一部分的闭孔器通过指示包围套管中的侧孔的位置来增强磁共振成像(MRI)的使用。 套管(例如,分离的探针,尺寸设置成接纳芯活检探针的套管)包括用于取组织样本的侧孔。 当插入代替活检装置的闭塞器插入插管中时,形成在闭孔器的轴中的凹口对应于侧孔。 进入切口的独立槽可以进一步接受含水材料以进一步强化侧孔。 另外,通过轴的侧表面连通并且靠近侧孔的一系列尺寸不同的孔(例如,孔,板条)接收含水材料以增强MRI图像中的可视性,即使在偏斜的MRI 穿过套管/闭孔器切片。
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公开(公告)号:US08461352B2
公开(公告)日:2013-06-11
申请号:US13416157
申请日:2012-03-09
申请人: Narendra Bhalchandra Ambhaikar , Brian Richard Bear , Lev T. D. Fanning , Robert Hughes , Benjamin Littler
发明人: Narendra Bhalchandra Ambhaikar , Brian Richard Bear , Lev T. D. Fanning , Robert Hughes , Benjamin Littler
IPC分类号: C07D487/08
CPC分类号: C07D487/08
摘要: The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof.
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公开(公告)号:US08201712B2
公开(公告)日:2012-06-19
申请号:US12026678
申请日:2008-02-06
IPC分类号: G01F11/00
CPC分类号: B67D1/0078 , B32B1/02 , B32B3/02 , B32B3/28 , B32B15/08 , B32B15/20 , B32B27/08 , B32B27/10 , B32B2307/40 , B32B2307/50 , B32B2307/546 , B32B2307/7265 , B32B2439/00 , B32B2439/70 , B65D5/563 , B67D1/0801 , B67D2001/0812 , B67D2001/0827
摘要: A dispenser for combining a number of ingredients. The dispenser may include a laminated container with one of the number of ingredients therein and a pump in communication with the laminated container.
摘要翻译: 用于组合多种成分的分配器。 分配器可以包括其中具有多个成分中的一个的层压容器和与层压容器连通的泵。
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公开(公告)号:US20100089948A1
公开(公告)日:2010-04-15
申请号:US12251469
申请日:2008-10-15
CPC分类号: B67D1/07 , B67D1/0021 , B67D1/0043 , B67D1/0044 , B67D1/0857
摘要: A beverage dispensing system using a sweetener. The beverage dispensing system may include a dispensing nozzle, a sweetener source with the sweetener at more than about 65° brix, a first diluent source with a first diluent, a mixing chamber in communication with the sweetener source and the first diluent source so as to dilute the sweetener to less than about 65° brix, and a second diluent source with a second diluent so as to dilute further the sweetener upstream of the dispensing nozzle.
摘要翻译: 一种使用甜味剂的饮料分配系统。 饮料分配系统可以包括分配喷嘴,甜味剂源,其甜味剂具有大于约65°的白利糖度,具有第一稀释剂的第一稀释剂源,与甜味剂源和第一稀释剂源连通的混合室,以便 将甜味剂稀释至小于约65°白利糖度,并用第二稀释剂稀释第二稀释剂源,以便在分配喷嘴上游进一步稀释甜味剂。
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公开(公告)号:US07645780B2
公开(公告)日:2010-01-12
申请号:US11447789
申请日:2006-06-06
申请人: Varghese John , Michel Maillard , James P. Beck , Eric T. Baldwin , Robert Hughes , Shon R. Pulley , Ruth T. TenBrink
发明人: Varghese John , Michel Maillard , James P. Beck , Eric T. Baldwin , Robert Hughes , Shon R. Pulley , Ruth T. TenBrink
IPC分类号: C07D213/56 , A61K31/44
CPC分类号: C07C233/36 , C07C235/10 , C07C235/74 , C07C271/24 , C07C311/05 , C07C327/30 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D209/14 , C07D213/38 , C07D213/64 , C07D215/233 , C07D215/38 , C07D215/42 , C07D215/46 , C07D217/22 , C07D233/61 , C07D233/64 , C07D237/08 , C07D237/14 , C07D239/26 , C07D239/38 , C07D241/12 , C07D249/08 , C07D261/08 , C07D265/02 , C07D277/28 , C07D295/135 , C07D307/52 , C07D309/14 , C07D311/68 , C07D311/74 , C07D333/20 , C07D333/22 , C07D335/06 , C07D405/04 , C07D407/06 , C07D409/12 , C07D495/04
摘要: Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
摘要翻译: 公开了下式的化合物:其中变量Z,X,R 15,R 2,R 3和R c在本文中定义。 本文公开的化合物是β-分泌酶的抑制剂,因此可用于治疗阿尔茨海默病和以哺乳动物中Aβ肽沉积为特征的其它疾病。
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公开(公告)号:US20070005758A1
公开(公告)日:2007-01-04
申请号:US11354800
申请日:2006-02-15
申请人: Robert Hughes , Yves Arrouye
发明人: Robert Hughes , Yves Arrouye
IPC分类号: G06F15/173
CPC分类号: H04N21/4431 , G06F21/51 , H04N21/4424
摘要: A security system is described which controls the access of applications to system resources in the field of interactive multimedia. The system establishes a framework for application security, including a signature system, and further provides file formats that support security. Signed applications are afforded high access privileges, while unsigned applications are afforded low access privileges. The combination of signed and unsigned applications on, e.g., a disk, provides for low access privileges for all applications, signed and unsigned.
摘要翻译: 描述了一种安全系统,其控制应用程序在交互式多媒体领域对系统资源的访问。 系统建立了应用程序安全性框架,包括签名系统,并进一步提供支持安全性的文件格式。 签名的应用程序具有高访问权限,而未签名的应用程序则具有低访问权限。 签名和未签名的应用程序(例如,磁盘)的组合为所有应用程序(签名和未签名)提供低访问权限。
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公开(公告)号:US20060223936A1
公开(公告)日:2006-10-05
申请号:US10498502
申请日:2002-12-20
申请人: Christopher Such , Ezio Rizzardo , Algirdas Serelis , Brian Hawkett , Robert Gilbert , Christopher Ferguson , Robert Hughes , Edna Olejnik
发明人: Christopher Such , Ezio Rizzardo , Algirdas Serelis , Brian Hawkett , Robert Gilbert , Christopher Ferguson , Robert Hughes , Edna Olejnik
IPC分类号: C08F8/30
CPC分类号: C07C329/00 , C07C329/16 , C08F2/38 , C08F4/00 , C08F293/005 , C08F2438/03
摘要: The invention provides a method for preparing an aqueous dispersion of polymer particles comprising the following steps: (i) preparing a dispersion having a continuous aqueous phase, a dispersed organic phase comprising one or more ethylenically unsaturated monomers, and an amphiphilic RAFT agent as a stabiliser for said organic phase, and (ii) polymerising said one or more ethylenically unsaturated monomers under the control of said amphiphilic RAFT agent to form said aqueous dispersion of polymer particles, novel amphiphilic RAFT agents for use in this method, novel RAFT agents useful in making these amphiphilic RAFT agents and methods for their manufacture.
摘要翻译: 本发明提供一种制备聚合物颗粒的水分散体的方法,包括以下步骤:(i)制备具有连续水相的分散体,包含一种或多种烯属不饱和单体的分散有机相和两亲性RAFT剂作为稳定剂 对于所述有机相,和(ii)在所述两亲RAFT试剂的控制下聚合所述一种或多种烯属不饱和单体以形成聚合物颗粒的所述水分散体,用于该方法的新型两亲性RAFT试剂,用于制备的新型RAFT试剂 这些两亲RAFT药剂及其制造方法。
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