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    Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists
    2.
    发明授权
    Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists 失效
    八氢吡喃[3,4-C]吡咯速激肽受体拮抗剂

    公开(公告)号：US07652058B2

    公开(公告)日：2010-01-26

    申请号：US11792514

    申请日：2005-12-12

    申请人： Robert J. DeVita ,  Jinlong Jiang ,  Sander G. Mills ,  Jonathan R. Young

    发明人： Robert J. DeVita ,  Jinlong Jiang ,  Sander G. Mills ,  Jonathan R. Young

    IPC分类号： A61K31/407 ,  C07D491/052

    CPC分类号： C07D491/04

    摘要： The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

    摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些氢吡喃并吡咯烷化合物。本发明还涉及包含这些化合物作为活性成分的药物组合物和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。

    Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists
    4.
    发明申请
    Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists 失效
    八氢吡喃[3,4-C]吡咯速激肽受体拮抗剂

    公开(公告)号：US20080108689A1

    公开(公告)日：2008-05-08

    申请号：US11792514

    申请日：2005-12-12

    申请人： Robert J. Devita ,  Jinlong Jiang ,  Sander G. Mills ,  Jonathan R. Young

    发明人： Robert J. Devita ,  Jinlong Jiang ,  Sander G. Mills ,  Jonathan R. Young

    IPC分类号： A61K31/407 ,  C07D491/052 ,  A61P43/00

    CPC分类号： C07D491/04

    摘要： The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

    摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些氢吡喃并吡咯烷化合物。本发明还涉及包含这些化合物作为活性成分的药物组合物和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。

    5,6,Fused Pyrrolidine Compounds Useful as Tachykinin Receptor Antagonists
    7.
    发明申请
    5,6,Fused Pyrrolidine Compounds Useful as Tachykinin Receptor Antagonists 审中-公开
    5,6，用作速激肽受体拮抗剂的熔融吡咯烷化合物

    公开(公告)号：US20090286777A1

    公开(公告)日：2009-11-19

    申请号：US12226294

    申请日：2007-05-11

    申请人： Jianming Bao ,  Robert J. DeVita ,  Sander G. Mills ,  Gregori J. Morriello

    发明人： Jianming Bao ,  Robert J. DeVita ,  Sander G. Mills ,  Gregori J. Morriello

    IPC分类号： A61K31/437 ,  C07D471/04 ,  A61K31/5377 ,  A61K31/506

    CPC分类号： C07D471/04

    摘要： The present invention is directed to certain 5,6-fused pyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

    摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂的某些5,6-稠合的吡咯烷化合物，以及速激肽抑制剂，特别是物质P。本发明还涉及包含这些化合物的药物制剂 作为活性成分以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，抑郁和焦虑）中的用途。

    Hydroxymethyl ether hydroisoindoline tachykinin receptor antagonists
    9.
    发明授权
    Hydroxymethyl ether hydroisoindoline tachykinin receptor antagonists 有权
    羟甲醚加氢异吲哚啉速效肽受体拮抗剂

    公开(公告)号：US08124633B2

    公开(公告)日：2012-02-28

    申请号：US12593168

    申请日：2008-04-07

    申请人： Robert J. DeVita ,  Sander G. Mills ,  Jinlong Jiang ,  Andrew J. Kassick ,  Jianming Bao

    发明人： Robert J. DeVita ,  Sander G. Mills ,  Jinlong Jiang ,  Andrew J. Kassick ,  Jianming Bao

    IPC分类号： A61K31/422 ,  C07D209/02

    CPC分类号： C07D209/44 ,  C07D413/04

    摘要： The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.

    摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的羟甲基醚异二氢吲哚化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂 以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，LUTS，抑郁和焦虑）中的用途。