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公开(公告)号：US20080146588A1
公开(公告)日：2008-06-19
申请号：US11791267
申请日：2005-11-18
IPC分类号： A61K31/497 , C07D221/00 , C07D241/10 , A61K31/445 , A61P25/00 , A61P13/02 , A61P29/00 , A61K31/454 , A61K31/4545
CPC分类号： C07D211/46 , C07D211/58 , C07D401/14
摘要： The present invention is directed to certain piperidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂的哌啶化合物和速激肽抑制剂，特别是物质P。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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公开(公告)号：US20080153851A1
公开(公告)日：2008-06-26
申请号：US11667906
申请日：2005-11-18
IPC分类号： A61K31/506 , A61P25/06 , A61P25/00 , A61P25/22 , A61K31/45 , A61K31/454 , C07D211/22 , C07D401/08
CPC分类号： C07D211/46 , C07D401/08
摘要： The present invention is directed to certain piperidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂的哌啶化合物和速激肽抑制剂，特别是物质P。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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![Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists](/abs-image/US/2010/01/26/US07652058B2/abs.jpg.150x150.jpg)
公开(公告)号：US07652058B2
公开(公告)日：2010-01-26
申请号：US11792514
申请日：2005-12-12
IPC分类号： A61K31/407 , C07D491/052
CPC分类号： C07D491/04
摘要： The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些氢吡喃并吡咯烷化合物。本发明还涉及包含这些化合物作为活性成分的药物组合物和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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![Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists](/abs-image/US/2008/05/08/US20080108689A1/abs.jpg.150x150.jpg)
公开(公告)号：US20080108689A1
公开(公告)日：2008-05-08
申请号：US11792514
申请日：2005-12-12
IPC分类号： A61K31/407 , C07D491/052 , A61P43/00
CPC分类号： C07D491/04
摘要： The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些氢吡喃并吡咯烷化合物。本发明还涉及包含这些化合物作为活性成分的药物组合物和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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公开(公告)号：US07468437B2
公开(公告)日：2008-12-23
申请号：US10572444
申请日：2004-09-24
IPC分类号： C07D239/00 , C07D213/04 , C07D207/00 , C07D233/00 , C07D333/02 , C07D321/00 , C07D307/00 , A01N43/58 , A01N43/64 , A61K31/41 , A61K31/38 , A61K31/335
CPC分类号： C07D207/08 , C07D401/04 , C07D401/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D513/04
摘要： The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂的苯基吡咯烷醚化合物，以及速激肽抑制剂，特别是物质P。本发明还涉及包含这些化合物作为活性成分的药物制剂 以及化合物及其制剂在治疗某些疾病（包括呕吐，抑郁和焦虑）中的用途。
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公开(公告)号：US20100105747A1
公开(公告)日：2010-04-29
申请号：US12593168
申请日：2008-04-07
IPC分类号： A61K31/422 , C07D209/02 , C07D413/04 , A61K31/40
CPC分类号： C07D209/44 , C07D413/04
摘要： The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的羟甲基醚异二氢吲哚化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂 以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，LUTS，抑郁和焦虑）中的用途。
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7.发明申请5,6,Fused Pyrrolidine Compounds Useful as Tachykinin Receptor Antagonists 审中-公开5,6，用作速激肽受体拮抗剂的熔融吡咯烷化合物公开(公告)号：US20090286777A1
公开(公告)日：2009-11-19
申请号：US12226294
申请日：2007-05-11
IPC分类号： A61K31/437 , C07D471/04 , A61K31/5377 , A61K31/506
CPC分类号： C07D471/04
摘要： The present invention is directed to certain 5,6-fused pyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂的某些5,6-稠合的吡咯烷化合物，以及速激肽抑制剂，特别是物质P。本发明还涉及包含这些化合物的药物制剂 作为活性成分以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，抑郁和焦虑）中的用途。
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![Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists](/abs-image/US/2009/02/19/US20090048248A1/abs.jpg.150x150.jpg)
公开(公告)号：US20090048248A1
公开(公告)日：2009-02-19
申请号：US12086810
申请日：2006-12-18
申请人： Robert J. DeVita , Jianming Bao , Sander G. Mills
发明人： Robert J. DeVita , Jianming Bao , Sander G. Mills
IPC分类号： A61K31/407 , C07D491/052 , A61K31/5377 , A61K31/4439 , A61K31/506 , A61K31/497 , A61K31/427 , A61K31/422 , A61K31/4196
CPC分类号： C07D491/04
摘要： The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些氢吡喃并吡咯烷化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂， 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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公开(公告)号：US08124633B2
公开(公告)日：2012-02-28
申请号：US12593168
申请日：2008-04-07
IPC分类号： A61K31/422 , C07D209/02
CPC分类号： C07D209/44 , C07D413/04
摘要： The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的羟甲基醚异二氢吲哚化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂 以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，LUTS，抑郁和焦虑）中的用途。
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10.发明申请Hexahydro-3H-Pyrrolizin-3-Ones Useful as Tachykinin Receptor Antagonists 审中-公开六氢-3H-吡咯啉-3-酮可用作速激肽受体拮抗剂公开(公告)号：US20090042854A1
公开(公告)日：2009-02-12
申请号：US12087141
申请日：2007-01-19
IPC分类号： A61K31/397 , C07D401/02 , C07D401/14 , C07D403/02 , C07D403/14 , A61K31/506 , A61K31/454 , A61K31/4155 , A61K31/403 , A61P29/00 , A61P13/00 , A61P25/00 , A61P1/00 , A61P11/00 , A61K31/4196 , A61K31/4192 , A61K31/4184 , A61K31/426 , A61K31/4439 , A61K31/5377 , C07D413/02 , C07D413/14 , C07D209/52
CPC分类号： C07D487/04 , C07B2200/07 , C07B2200/09 , C07D498/04
摘要： The present invention is directed to certain hexahydrpyrrolidinone compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些六氢吡咯烷酮化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂， 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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