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公开(公告)号：US07960536B2
公开(公告)日：2011-06-14
申请号：US11080827
申请日：2005-03-14
申请人： Robert J. Schwartz , Eric M. Eastman , Xuyang Li , Jeff Nordstrom
发明人： Robert J. Schwartz , Eric M. Eastman , Xuyang Li , Jeff Nordstrom
IPC分类号： C12N15/63
CPC分类号： C12N15/1051 , C12N15/1034 , C12Q1/6811 , C12Q1/6876 , C12Q1/6897 , C12Q2600/158
摘要： The invention concerns making and evaluating synthetic regulatory regions for controlling gene expression. The invention features a method for identifying transcription factor binding sites and a method for evaluating the regulatory functions of synthetic regulatory regions.
摘要翻译： 本发明涉及制备和评估用于控制基因表达的合成调节区。 本发明特征在于鉴定转录因子结合位点的方法和评估合成调节区的调节功能的方法。
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2.发明授权Method for the identification of synthetic cell- or tissue- specific transcriptional regulatory regions 失效用于鉴定合成细胞或组织特异性转录调节区的方法公开(公告)号：US06410228B1
公开(公告)日：2002-06-25
申请号：US09115407
申请日：1998-07-14
申请人： Robert J. Schwartz , Eric M. Eastman , Xuyang Li , Jeff Nordstrom
发明人： Robert J. Schwartz , Eric M. Eastman , Xuyang Li , Jeff Nordstrom
IPC分类号： C12Q168
CPC分类号： C12N15/1051 , C12N15/1034 , C12Q1/6811 , C12Q1/6876 , C12Q1/6897 , C12Q2600/158
摘要： The invention concerns making and evaluating synthetic regulatory regions for controlling gene expression. The invention features a method for identifying transcription factor binding sites and a method for evaluating the regulatory functions of synthetic regulatory regions.
摘要翻译： 本发明涉及制备和评估用于控制基因表达的合成调节区。 本发明特征在于鉴定转录因子结合位点的方法和评估合成调节区的调节功能的方法。
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3.发明授权Growth hormone releasing hormone expression system and methods of use, including use in animals 失效生长激素释放激素表达系统及使用方法，包括用于动物公开(公告)号：US06423693B1
公开(公告)日：2002-07-23
申请号：US09122171
申请日：1998-07-24
IPC分类号： A61K3170
CPC分类号： A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/02 , A01K2267/03 , A61K38/25 , A61K48/00 , A61K48/0008 , A61K48/0058 , C07K14/60 , C07K2319/00 , C12N15/85 , C12N15/8509 , C12N2799/021
摘要： Vectors which establish controlled expression of recombinant GHRH genes within tissues at certain levels. The vector includes a 5′ flanking region which includes necessary sequences for expression of a nucleic acid cassette, a 3′ flanking region including a 3′UTR and/or 3′NCR, and a linker which connects the 5′ flanking region to a nucleic acid sequence. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. The 3′ flanking region is 3′ to the position for inserting the nucleic acid cassette.
摘要翻译： 在某些水平的组织内建立重组GHRH基因的受控表达的载体。 载体包括5'侧翼区，其包含用于表达核酸盒的必需序列，包含3'UTR和/或3'NCR的3'侧翼区和将5'侧翼区连接到核酸的连接体 酸序列。 接头具有用于插入核酸盒的位置。 接头不包含接头天然相关基因的编码序列。 3'侧翼区域为插入核酸盒的位置3'。
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公开(公告)号：US5763270A
公开(公告)日：1998-06-09
申请号：US484723
申请日：1995-06-07
申请人： Eric M. Eastman , Ross H. Durland
发明人： Eric M. Eastman , Ross H. Durland
CPC分类号： C12N15/85 , C12N15/70 , A61K48/00 , C12N2800/30 , C12N2820/002 , C12N2820/55 , C12N2830/002 , C12N2830/006 , C12N2830/36 , C12N2830/55 , C12N2840/20
摘要： This invention relates to plasmid constructs useful for nonviral human gene therapy. The plasmid constructs incorporate plasmid elements for achieving high copy number, avoiding plasmid instability an providing a plasmid selection process. These constructs can be used to deliver nucleic acids to cells in vehicles which are compatible with human therapeutic use.
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5.发明申请MICRORNA SIGNATURES INDICATIVE OF IMMUNOMODULATING THERAPY FOR MULTIPLE SCLEROSIS 审中-公开指示多发性硬化症免疫调节治疗的MICRORNA标志公开(公告)号：US20120214682A1
公开(公告)日：2012-08-23
申请号：US13359675
申请日：2012-01-27
CPC分类号： C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178
摘要： The present invention provides methods, systems, and kits for evaluating multiple sclerosis (MS) in a patient. Particularly, the invention provides convenient miRNA-based tests for evaluating a patient for MS, including for diagnosing MS, for excluding MS as a diagnosis, and for monitoring the course of disease or efficacy of treatment, including evaluation of immunomodulating therapy.
摘要翻译： 本发明提供了用于评估患者多发性硬化（MS）的方法，系统和试剂盒。 特别地，本发明提供了用于评估患者MS的方便的基于miRNA的测试，包括用于诊断MS，排除MS作为诊断，以及用于监测疾病进程或治疗功效，包括免疫调节治疗的评估。
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公开(公告)号：US6103470A
公开(公告)日：2000-08-15
申请号：US1770
申请日：1997-12-31
申请人： Eric M. Eastman , Ross H. Durland
发明人： Eric M. Eastman , Ross H. Durland
CPC分类号： C12N15/85 , C12N15/70 , A61K48/00 , C12N2800/30 , C12N2820/002 , C12N2820/55 , C12N2830/002 , C12N2830/006 , C12N2830/36 , C12N2830/55 , C12N2840/20
摘要： This invention relates to plasmid constructs useful for nonviral human gene therapy. The plasmid constructs incorporate plasmid elements for achieving high copy number, avoiding plasmid instability an providing a plasmid selection process. These constructs can be used to deliver nucleic acids to cells in vehicles which are compatible with human therapeutic use.
摘要翻译： 本发明涉及可用于非病毒人基因治疗的质粒构建体。 质粒构建体包含用于实现高拷贝数的质粒元件，避免了提供质粒选择过程的质粒不稳定性。 这些构建体可用于将核酸递送至与人类治疗用途相容的载体中的细胞。
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