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    Molecularly Imprinted Polymers for Use as Imaging and Therapeutics Agents
    1.
    发明申请
    Molecularly Imprinted Polymers for Use as Imaging and Therapeutics Agents 审中-公开
    分子印迹聚合物用作成像和治疗剂

    公开(公告)号：US20120093720A1

    公开(公告)日：2012-04-19

    申请号：US13274093

    申请日：2011-10-14

    申请人： Robert Jones ,  Thomas Beck

    发明人： Robert Jones ,  Thomas Beck

    IPC分类号： A61K49/00 ,  A61K51/06 ,  C08G65/34

    CPC分类号： A61K49/0002 ,  A61K51/06 ,  A61K51/1244 ,  C08G65/329 ,  C08L71/02 ,  C08L2203/02

    摘要： The invention described herein provides biocompatible molecularly imprinted polymers (MIPs) that are non-toxic, water soluble, small molecular weight, and degradable in a living body. The MIPs are capable of binding to all or a portion of a specific target macromolecule associated with a disease located within the living body and they are derivatized for stealth for in vivo applications to avoid the reticuloendothelial system. The MIPs of the invention are functionalized to an amine or carboxyl group and are derivatized with an imaging and/or therapeutic agent for taking images of the disease and/or for providing therapy. The macromolecule can be selected from a group consisting of proteins, glycoproteins, lipoproteins, peptidoglycans, peptides, polypeptides, polynucleotides, and polysaccharides. The invention described herein also provides methods and kits wherein MIPs of the invention can be employed as targeted imaging and therapeutic agents.

    摘要翻译： 本文描述的本发明提供了生物相容性分子印迹聚合物（MIP），其在生物体中是无毒的，水溶性的，小分子量的和可降解的。 MIP能够结合与位于生物体内的疾病相关的特定目标大分子的全部或一部分，并且它们被衍生化用于隐形以用于体内应用以避免网状内皮系统。 本发明的MIP被官能化为胺或羧基，并且用成像和/或治疗剂衍生以获取疾病图像和/或用于提供治疗。 大分子可以选自蛋白质，糖蛋白，脂蛋白，肽聚糖，肽，多肽，多核苷酸和多糖。 本文所述的发明还提供了本发明的MIP可用作靶向成像和治疗剂的方法和试剂盒。

    Establishing a magnetic resonance system actuation sequence
    2.
    发明授权
    Establishing a magnetic resonance system actuation sequence 有权

    公开(公告)号：US09791531B2

    公开(公告)日：2017-10-17

    申请号：US14231118

    申请日：2014-03-31

    申请人： Thomas Beck ,  Rainer Schneider

    发明人： Thomas Beck ,  Rainer Schneider

    IPC分类号： G01R33/24 ,  G01R33/54 ,  G01R33/58

    CPC分类号： G01R33/543 ,  G01R33/243 ,  G01R33/246 ,  G01R33/583

    摘要： A method for establishing a magnetic resonance system actuation sequence is described. A first number of field distribution maps are acquired for slices of the measurement region, and a radiofrequency pulse train is established on the basis thereof for the magnetic resonance system actuation sequence. This acquisition of the first number of field distribution maps may be brought about on the basis of an acquisition scheme. A reduced number of field distribution representation maps are established on the basis of the acquired field distribution maps, which field distribution representation maps represent the first number of acquired field distribution maps in accordance with a predetermined optimization criterion, and the radiofrequency pulse train is established on the basis of the field distribution representation maps.

    Method for producing a hole
    4.
    发明授权
    Method for producing a hole 有权
    孔的制造方法

    公开(公告)号：US08618439B2

    公开(公告)日：2013-12-31

    申请号：US13397057

    申请日：2012-02-15

    申请人： Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

    发明人： Thomas Beck ,  Nigel-Philip Cox ,  Silke Settegast

    IPC分类号： B23K26/38 ,  B23K15/08

    CPC分类号： B23K15/085 ,  B23K26/384 ,  B23K26/389 ,  B23K2101/001 ,  F01D5/186 ,  F05D2230/13 ,  Y02T50/67 ,  Y02T50/676 ,  Y10T29/49341

    摘要： There are a multiplicity of methods of making through-holes. In particular in the production of a multiplicity of film-cooling holes, as in gas turbine blades or combustion chamber elements, small time advantages are also important when making a hole. The method according to the invention, to make the hole close to the final contour in each case in sections in a top and a bottom region in order to then produce the final contour with other laser parameters, achieves time advantages.

    摘要翻译： 有多种形成通孔的方法。 特别是在制造多个薄膜冷却孔时，如在燃气轮机叶片或燃烧室元件中，小的时间优点在制造孔时也是重要的。 根据本发明的方法，为了使其在顶部和底部区域中的每一种情况下，使得孔接近于最终轮廓，以便随后用其他激光参数产生最终轮廓，这实现了时间优点。

    KALLIKREIN INHIBITORS AND ANTI-THROMBOLYTIC AGENTS AND USES THEREOF
    5.
    发明申请
    KALLIKREIN INHIBITORS AND ANTI-THROMBOLYTIC AGENTS AND USES THEREOF 有权
    KALLIKREIN抑制剂和抗凝血剂及其用途

    公开(公告)号：US20130012438A1

    公开(公告)日：2013-01-10

    申请号：US13458086

    申请日：2012-04-27

    申请人： Henry Blair ,  Thomas Beck ,  Robert Charles Ladner

    发明人： Henry Blair ,  Thomas Beck ,  Robert Charles Ladner

    IPC分类号： A61K38/17 ,  A61P29/00 ,  A61P9/10 ,  A61K38/11

    CPC分类号： A61K38/55 ,  A61K31/195 ,  A61K38/57 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

    摘要翻译： 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂（例如抗纤维蛋白溶解剂）的方法，试剂盒和组合物，用于预防或减少失血和/或缺血，例如与围手术期失血相关的缺血 脑缺血，全身炎症反应发作和/或再灌注损伤，例如与脑缺血或局灶性脑缺血相关的再灌注损伤，例如在经历侵入性外科手术的患者中，特别是需要体外循环的手术。

    Method for producing a hole
    6.
    发明授权
    Method for producing a hole 有权
    孔的制造方法

    公开(公告)号：US08237082B2

    公开(公告)日：2012-08-07

    申请号：US12223204

    申请日：2007-01-05

    申请人： Thomas Beck ,  Silke Settegast

    发明人： Thomas Beck ,  Silke Settegast

    IPC分类号： B23K26/38

    CPC分类号： B23K26/0648 ,  B23K26/0622 ,  B23K26/064 ,  B23K26/0665 ,  B23K26/389

    摘要： There is described a method for producing a hole using e.g. a lasers, wherein short laser pulse durations are used. The laser pulse durations are varied, short laser pulse durations being utilized only in the area to be removed in which an influence on the penetration behavior and discharge behavior is noticeable while longer pulse durations of >0.4 ms are used. This is the case for the inner surface of a diffuser of a hole, for example, which can be produced very accurately by means of short laser pulse durations.

    摘要翻译： 描述了使用例如制造孔的方法。 激光器，其中使用短激光脉冲持续时间。 激光脉冲持续时间是变化的，短激光脉冲持续时间仅在要去除的区域中被使用，其中在使用> 0.4ms的较长脉冲持续时间时，对穿透行为和放电行为的影响是显着的。 这是例如孔的扩散器的内表面的情况，例如，可以通过短的激光脉冲持续时间非常精确地制造。

    Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
    7.
    发明授权
    Kallikrein inhibitors and anti-thrombolytic agents and uses thereof 有权
    激肽释放酶抑制剂和抗溶栓剂及其用途

    公开(公告)号：US08188045B2

    公开(公告)日：2012-05-29

    申请号：US11804388

    申请日：2007-05-18

    申请人： Henry Blair ,  Thomas Beck ,  Robert C. Ladner

    发明人： Henry Blair ,  Thomas Beck ,  Robert C. Ladner

    IPC分类号： A61K38/16 ,  A61P7/02 ,  C07K14/00

    CPC分类号： A61K38/55 ,  A61K31/195 ,  A61K38/57 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

    摘要翻译： 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂（例如抗纤维蛋白溶解剂）的方法，试剂盒和组合物，用于预防或减少失血和/或缺血，例如与围手术期失血相关的缺血 脑缺血，全身炎症反应发作和/或再灌注损伤，例如与脑缺血或局灶性脑缺血相关的再灌注损伤，例如在经历侵入性外科手术的患者中，特别是需要体外循环的手术。

    Method for the production of a hole and device
    9.
    发明授权
    Method for the production of a hole and device 有权
    生产孔和装置的方法

    公开(公告)号：US07816625B2

    公开(公告)日：2010-10-19

    申请号：US10574724

    申请日：2004-09-02

    申请人： Thomas Beck ,  Georg Bostanjoglo

    发明人： Thomas Beck ,  Georg Bostanjoglo

    IPC分类号： B23K26/00 ,  B23K26/06

    CPC分类号： B23K26/0608 ,  B23K26/0622 ,  B23K26/389 ,  B23K26/40 ,  B23K2101/001 ,  B23K2103/172 ,  B23K2103/52

    摘要： Previous methods for the production of a hole in a component are very time-consuming and expensive, as special lasers having ultra short laser pulse lengths are used. The inventive method varies laser pulse lengths and ultra short laser pulse lengths are used exclusively in the region which is to be removed, wherein it is possible to have a noticeable influence on through flow and/or out-flow behavior. This, for example, the inner surface of a diffuser of a hole, which can be produced in a precise manner using ultra short laser pulse lengths.

    摘要翻译： 由于使用具有超短激光脉冲长度的特殊激光器，因此在组件中产生孔的先前方法非常耗时且昂贵。 本发明的方法改变激光脉冲长度，并且超短激光脉冲长度仅用于要去除的区域中，其中可能对通过流动和/或流出行为具有明显的影响。 例如，可以使用超短激光脉冲长度精确地制造孔的扩散器的内表面。