公开(公告)号：US06258109B1

公开(公告)日：2001-07-10

申请号：US09656339

申请日：2000-09-06

申请人： Robert Lawrence Barry ,  Matt Hefner ,  Tom Hiblar ,  Joseph Pearce ,  Natalya Peskin ,  Edward Wulfman

发明人： Robert Lawrence Barry ,  Matt Hefner ,  Tom Hiblar ,  Joseph Pearce ,  Natalya Peskin ,  Edward Wulfman

IPC分类号： A61B1722

CPC分类号： A61B17/320758 ,  A61B2017/320004

摘要： A guide wire for use in atherectomy procedures has a bearing with a static member fixedly secured to the guide wire and a dynamic member rotatably engaged to the static member. The dynamic member can rotate with an atherectomy burr if the burr engages the bearing.

摘要翻译： 用于粥样斑块切除术的导丝具有固定在引导线上的静止部件和与该静止部件可旋转接合的动力部件的轴承。 如果毛刺接合轴承，动态构件可以用粥状斑切除术毛发旋转。

公开(公告)号：US06270509B1

公开(公告)日：2001-08-07

申请号：US09655907

申请日：2000-09-06

申请人： Robert Lawrence Barry ,  Matt Hefner ,  Tom Hiblar ,  Joseph Pearce ,  Natalya Peskin ,  Edward Wulfman

发明人： Robert Lawrence Barry ,  Matt Hefner ,  Tom Hiblar ,  Joseph Pearce ,  Natalya Peskin ,  Edward Wulfman

IPC分类号： A61B1722

CPC分类号： A61B17/320758 ,  A61B2017/320004

摘要： An ablation burr has a body provided with an inner circumferential rim and an outer circumferential rim that are concentric and spaced longitudinally by a selected distance along the length of the burr. The outer circumferential rim has a generally smooth convex outer surface that reduces damage to a vessel wall or stent. A leading surface of the burr extends between the inner and outer circumferential rims in a substantially uniform, concave manner. An abrasive, for example, diamond grit, is provided on the leading surface. The burr is selectively rotated by a drive shaft, causing the abrasive leading surface of the burr to ablate unwanted deposits. If desired, a wire extends co-axially thorough the body such that a distal end of the wire extends out of the distal end of the burr. An abrasive tip may be coupled to the distal end of the wire, and is selectively rotated, to ablate unwanted deposits. The burr may be made of a compressible elastomeric material, to facilitate positioning the burr through restrictive openings, such as the coronary ostia. To prevent the burr from becoming welded to a spring tip at the end of the guide wire, a bearing may be provided at a distal region of the guide wire. The bearing has a dynamic member that acts as a bumper and rotates when the ablation device is advanced to the distal region of the guide wire and contacts the dynamic member. The leading surface of the burr may include one or more aspiration ports through which debris that is ablated from the occlusion may be removed from a patient's vessel.

摘要翻译： 消融毛刺具有主体，该主体设置有内圆周边缘和外圆周边缘，所述内圆周边缘和外圆周边缘同心且沿着毛刺长度方向间隔一段选定距离。 外圆周边缘具有大致平滑的凸形外表面，其减小对血管壁或支架的损伤。 毛刺的前导表面以大致均匀的凹陷方式在内圆周边缘和外圆周边缘之间延伸。 研磨剂，例如金刚石砂粒，提供在前表面上。 毛刺被驱动轴选择性地旋转，导致毛刺的研磨引导表面烧蚀不需要的沉积物。 如果需要，线材同轴地延伸穿过本体，使得线材的远端延伸出毛刺的远端。 研磨尖端可以联接到线的远端，并且被选择性地旋转以消除不想要的沉积物。 毛刺可以由可压缩的弹性体材料制成，以便于通过诸如冠状动脉口的限制性开口将毛刺定位。 为了防止毛刺在引导线的端部焊接到弹簧尖端，可以在导丝的远侧区域处设置轴承。 轴承具有作为保险杠的动态构件，并且当消融装置前进到导丝的远侧区域并接触动态构件时旋转。 毛刺的前导表面可以包括一个或多个抽吸端口，通过该吸口可以从患者的血管中除去从闭塞中消除的碎屑。

公开(公告)号：US06183487B2

公开(公告)日：2001-02-06

申请号：US09178450

申请日：1998-10-23

申请人： Robert Lawrence Barry ,  Matt Hefner ,  Tom Hiblar ,  Joseph Pearce ,  Natalya Peskin ,  Edward Wulfman

发明人： Robert Lawrence Barry ,  Matt Hefner ,  Tom Hiblar ,  Joseph Pearce ,  Natalya Peskin ,  Edward Wulfman

IPC分类号： A61B1722

CPC分类号： A61B17/320758 ,  A61B2017/320004

摘要： An ablation burr has a body provided with an inner circumferential rim and an outer circumferential rim that are concentric and spaced longitudinally by a selected distance along the length of the burr. The outer circumferential rim has a generally smooth convex outer surface that reduces damage to a vessel wall or stent. A leading surface of the burr extends between the inner and outer circumferential rims in a substantially uniform, concave manner. An abrasive, for example, diamond grit, is provided on the leading surface. The burr is selectively rotated by a drive shaft, causing the abrasive leading surface of the burr to ablate unwanted deposits. If desired, a wire extends co-axially through the body such that a distal end of the wire extends out of the distal end of the burr. An abrasive tip may be coupled to the distal end of the wire, and is selectively rotated, to ablate unwanted deposits. The burr may be made of a compressible elastomeric material, to facilitate positioning the burr through restrictive openings, such as the coronary ostia. To prevent the burr from becoming welded to a spring tip at the end of the guide wire, a bearing may be provided at a distal region of the guide wire. The bearing has a dynamic member that acts as a bumper and rotates when the ablation device is advanced to the distal region of the guide wire and contacts the dynamic member. In an alternative embodiment of the invention, the leading surface of the burr includes one or more aspiration ports through which debris that is ablated from the occlusion may be removed from a patient's vessel.

摘要翻译： 消融毛刺具有主体，该主体设置有内圆周边缘和外圆周边缘，所述内圆周边缘和外圆周边缘同心且沿着毛刺长度方向间隔一段选定距离。 外圆周边缘具有大致平滑的凸形外表面，其减小对血管壁或支架的损伤。 毛刺的前导表面以大致均匀的凹陷方式在内圆周边缘和外圆周边缘之间延伸。 研磨剂，例如金刚石砂粒，提供在前表面上。 毛刺被驱动轴选择性地旋转，导致毛刺的研磨引导表面烧蚀不需要的沉积物。 如果需要，线材同轴地延伸通过本体，使得线材的远端延伸出毛刺的远端。 研磨尖端可以联接到线的远端，并且被选择性地旋转以消除不想要的沉积物。 毛刺可以由可压缩的弹性体材料制成，以便于通过诸如冠状动脉口的限制性开口将毛刺定位。 为了防止毛刺在引导线的端部焊接到弹簧尖端，可以在导丝的远侧区域处设置轴承。 轴承具有作为保险杠的动态构件，并且当消融装置前进到导丝的远侧区域并接触动态构件时旋转。 在本发明的替代实施例中，毛刺的前表面包括一个或多个抽吸端口，通过该抽吸端口可以从患者的血管移除从闭塞中消除的碎屑。

公开(公告)号：US06328750B1

公开(公告)日：2001-12-11

申请号：US09655905

申请日：2000-09-06

申请人： Robert Lawrence Berry ,  Matt Hefner ,  Tom Hiblar ,  Joseph Pearce ,  Natalya Peskin ,  Edward Wulfman

发明人： Robert Lawrence Berry ,  Matt Hefner ,  Tom Hiblar ,  Joseph Pearce ,  Natalya Peskin ,  Edward Wulfman

IPC分类号： A61B1732

CPC分类号： A61B17/320758 ,  A61B2017/320004

摘要： An ablation burr has a body provided with an inner circumferential rim and an outer circumferential rim that are concentric and spaced longitudinally by a selected distance along the length of the burr. The outer circumferential rim has a generally smooth convex outer surface that reduces damage to a vessel wall or stent A leading surface of the burr extends between the inner and outer circumferential rims in a substantially uniform, concave manner. An abrasive, for example, diamond grit, is provided on the leading surface. The burr is selectively rotated by a drive shaft, causing the abrasive leading surface of the burr to ablate unwanted deposits. If desired, a wire extends co-axially through the body such that a distal end of the wire extends out of the distal end of the burr. An abrasive tip may be coupled to the distal end of the wire, and is selectively rotated, to ablate unwanted deposits. The burr may be made of a compressible elastomeric material, to facilitate positioning the burr through restrictive openings, such as the coronary ostia. To prevent the burr from becoming welded to a spring tip at the end of the guide wire, a bearing may be provided at a distal region of the guide wire. The bearing has a dynamic member that acts as a bumper and rotates when the ablation device is advanced to the distal region of the guide wire and contacts the dynamic member. In an alternative embodiment, the leading surface of the burr includes one or more aspiration ports through which debris that is ablated from the occlusion may be removed from a patient's vessel.

摘要翻译： 消融毛刺具有主体，该主体设置有内圆周边缘和外圆周边缘，所述内圆周边缘和外圆周边缘同心且沿着毛刺长度方向间隔一段选定距离。 外圆周边缘具有大致平滑的凸形外表面，其减小对血管壁或支架的损伤。毛刺的前表面以大致均匀的凹陷方式在内圆周边缘和外圆周边缘之间延伸。 研磨剂，例如金刚石砂粒，提供在前表面上。 毛刺被驱动轴选择性地旋转，导致毛刺的研磨引导表面烧蚀不需要的沉积物。 如果需要，线材同轴地延伸通过本体，使得线材的远端延伸出毛刺的远端。 研磨尖端可以联接到线的远端，并且被选择性地旋转以消除不想要的沉积物。 毛刺可以由可压缩的弹性体材料制成，以便于通过诸如冠状动脉口的限制性开口将毛刺定位。 为了防止毛刺在引导线的端部焊接到弹簧尖端，可以在导丝的远侧区域处设置轴承。 轴承具有作为保险杠的动态构件，并且当消融装置前进到导丝的远侧区域并接触动态构件时旋转。 在替代实施例中，毛刺的前表面包括一个或多个抽吸端口，通过该抽吸端口可以从患者的血管移除从闭塞中消除的碎屑。

公开(公告)号：US06416526B1

公开(公告)日：2002-07-09

申请号：US09589861

申请日：2000-06-08

申请人： Mark Wyzgala ,  Donald Baumgarten ,  Lucas S. Gordon ,  Eric B. Hamilton ,  Matt Hefner ,  Tom Hiblar ,  Edward Wulfman

发明人： Mark Wyzgala ,  Donald Baumgarten ,  Lucas S. Gordon ,  Eric B. Hamilton ,  Matt Hefner ,  Tom Hiblar ,  Edward Wulfman

IPC分类号： A61B1732

CPC分类号： A61B17/320725 ,  A61B17/320758 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/320004 ,  A61B2017/320733

摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. Alternatively, the burr may include a polymeric tube that is coated with an abrasive and secured to the proximal end of the burr. When the burr is rotated, the polymeric tube expands by centrifugal force. Alternatively, the burr may comprise a metallic strip wound over a mandrel. When the strip is tightly coiled to the mandrel, its outer diameter decreases. The outer diameter of the burr increases as the metallic strip expands. In addition, the burr can be formed as a wire spring wound over a drive tube. The distal end of the spring is coupled to a nose cone that can move within a distal lumen in the drive tube. The maximum expansion of the burr is controlled by the distance that the nose cone can be retracted into the lumen. In addition, the present invention includes a burr having an indexable outer diameter. Various indexing mechanisms are disclosed for selectively increasing or decreasing the distance between a proximal and distal end of the burr. As the length of the burr changes, the outer diameter of a number of cutting blades is changed to allow a physician to create different sized lumens in a patient's vessel.

摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。 或者，毛刺可以包括涂覆有研磨剂并固定到毛刺的近端的聚合物管。 当毛刺旋转时，聚合物管通过离心力膨胀。 或者，毛刺可以包括缠绕在心轴上的金属条。 当条带紧紧地卷绕到心轴上时，其外径减小。 毛边的外径随着金属条扩张而增加。 此外，毛刺可以形成为卷绕在驱动管上的线弹簧。 弹簧的远端联接到能够在驱动管内远端管腔内移动的鼻锥体。 毛刺的最大膨胀由鼻锥可以缩回到内腔的距离来控制。 此外，本发明包括具有可转位外径的毛刺。 公开了用于选择性地增加或减小毛刺的近端和远端之间的距离的各种分度机构。 随着毛刺的长度改变，许多切割刀片的外径被改变以允许医师在患者的血管中产生不同大小的腔。

公开(公告)号：US06096054A

公开(公告)日：2000-08-01

申请号：US178449

申请日：1998-10-23

申请人： Mark Wyzgala ,  Donald Baumgarten ,  Lucas S. Gordon ,  Eric B. Hamilton ,  Matt Hefner ,  Tom Hiblar ,  Edward Wulfman

发明人： Mark Wyzgala ,  Donald Baumgarten ,  Lucas S. Gordon ,  Eric B. Hamilton ,  Matt Hefner ,  Tom Hiblar ,  Edward Wulfman

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B17/32

CPC分类号： A61B17/320725 ,  A61B17/320758 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/320004 ,  A61B2017/320733

摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. Alternatively, the burr may include a polymeric tube that is coated with an abrasive and secured to the proximal end of the burr. When the burr is rotated, the polymeric tube expands by centrifugal force. Alternatively, the burr may comprise a metallic strip wound over a mandrel. When the strip is tightly coiled to the mandrel, its outer diameter decreases. The outer diameter of the burr increases as the metallic strip expands. In addition, the burr can be formed as a wire spring wound over a drive tube. The distal end of the spring is coupled to a nose cone that can move within a distal lumen in the drive tube. The maximum expansion of the burr is controlled by the distance that the nose cone can be retracted into the lumen. In addition, the present invention includes a burr having an indexable outer diameter. Various indexing mechanisms are disclosed for selectively increasing or decreasing the distance between a proximal and distal end of the burr. As the length of the burr changes, the outer diameter of a number of cutting blades is changed to allow a physician to create different sized lumens in a patient's vessel.

摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。 或者，毛刺可以包括涂覆有研磨剂并固定到毛刺的近端的聚合物管。 当毛刺旋转时，聚合物管通过离心力膨胀。 或者，毛刺可以包括缠绕在心轴上的金属条。 当条带紧紧地卷绕到心轴上时，其外径减小。 毛边的外径随着金属条扩张而增加。 此外，毛刺可以形成为卷绕在驱动管上的线弹簧。 弹簧的远端联接到能够在驱动管内远端管腔内移动的鼻锥体。 毛刺的最大膨胀由鼻锥可以缩回到内腔的距离来控制。 此外，本发明包括具有可转位外径的毛刺。 公开了用于选择性地增加或减小毛刺的近端和远端之间的距离的各种分度机构。 随着毛刺的长度改变，许多切割刀片的外径被改变以允许医师在患者的血管中产生不同大小的腔。

公开(公告)号：US06596005B1

公开(公告)日：2003-07-22

申请号：US09670416

申请日：2000-09-26

申请人： Bill Kanz ,  Denise Drummond ,  Robert Barry ,  Paul A. Hirst ,  Mark Wyzgala ,  Gary Swinford ,  Edward Wulfman ,  Tom Clement ,  Tom Kadavy

发明人： Bill Kanz ,  Denise Drummond ,  Robert Barry ,  Paul A. Hirst ,  Mark Wyzgala ,  Gary Swinford ,  Edward Wulfman ,  Tom Clement ,  Tom Kadavy

IPC分类号： A61D102

CPC分类号： A61B17/320758 ,  A61B17/320725 ,  A61B2017/003 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/320004 ,  A61B2017/320733 ,  A61B2017/320766

摘要： A catheter including an elongate drive shaft having a proximal end and a distal end, an ablation burr disposed at the distal end expandable between a first position and a second position, wherein in the second position has a greater transverse dimension than in the first position. The catheter of the present invention can include a mechanism for positioning the burr eccentrically within a vessel lumen. In this context, expansion means that the burr can ablate a lumen having a larger diameter than the diameter of the lumen of the guide catheter to which the device is advanced.

摘要翻译： 包括具有近端和远端的细长驱动轴的导管，设置在远端的消融毛刺可在第一位置和第二位置之间扩张，其中在第二位置具有比在第一位置更大的横向尺寸。 本发明的导管可以包括用于将毛刺偏心地定位在血管腔内的机构。 在这种情况下，膨胀意味着毛刺可以烧蚀具有比该装置前进的导管的内腔直径更大的直径的内腔。

公开(公告)号：US06299623B1

公开(公告)日：2001-10-09

申请号：US09589993

申请日：2000-06-08

申请人： Edward Wulfman

发明人： Edward Wulfman

IPC分类号： A61B1722

CPC分类号： A61B17/320758 ,  A61B2017/22039 ,  A61B2017/320004

摘要： An ablation device (10) includes a drive shaft (12) and an ablation burr (14) secured to the distal end of the drive shaft thereto. A guide wire (18) extends through the drive shaft and the ablation burr. To direct the ablation burr laterally within a patient's vessel, the atherectomy device includes one or more bias wires (30) that extend generally parallel to and spaced from the longitudinal axis of the drive shaft such that engagement of the bias wires against an obstruction in a patient's vessel will force the ablation burr to move laterally within a patient's blood vessel. To rotate the bias wires in a patient's blood vessel, the bias wire may be coupled to a catheter surrounding the drive shaft. Alternatively, the catheter is designed to engage the bias wires when the drive shaft is retracted into the catheter. The bias wires will then rotate as the catheter is rotated.

摘要翻译： 消融装置（10）包括固定到驱动轴的远端的驱动轴（12）和消融毛刺（14）。 引导线（18）延伸穿过驱动轴和消融毛刺。 为了将消融毛刺横向地引导到患者的血管内，动脉粥样斑块切除装置包括一个或多个偏置线（30），该偏置线大致平行于驱动轴的纵向轴线延伸并且与驱动轴的纵向轴线间隔开，使得偏置线与阻塞 患者的血管将迫使消融毛刺在患者的血管内横向移动。为了使患者血管中的偏置线旋转，偏置线可以联接到围绕驱动轴的导管。 或者，当驱动轴缩回到导管中时，导管被设计成接合偏置线。 然后当导管旋转时，偏置线将旋转。

公开(公告)号：US6156048A

公开(公告)日：2000-12-05

申请号：US365188

申请日：1999-08-02

申请人： Edward Wulfman ,  Lucas Gordon ,  Robert Barry ,  Brandon Shuman ,  David Dillard ,  Verivada Chandrasekaran

发明人： Edward Wulfman ,  Lucas Gordon ,  Robert Barry ,  Brandon Shuman ,  David Dillard ,  Verivada Chandrasekaran

IPC分类号： A61B17/32 ,  A61B17/22

CPC分类号： A61B17/320758 ,  A61B2017/320004

摘要： An atherectomy device that may reduce the risk of damage to a vessel wall. One rotatable atherectomy burr has a recessed material removal portion lying between less abrasive proximal and distal shoulders. The shoulders can have a straight, rounded or elliptical taper. The shoulders can perform a cam action when the burr is canted is a vessel, as when passing the burr and guide wire through a tortuous, stenosed vessel path. The shoulders act to align the burr with the path through the vessel, presenting the less abrasive shoulders to the vessel wall while presenting the abrasive portion to a stenosis.

公开(公告)号：US06800083B2

公开(公告)日：2004-10-05

申请号：US09829486

申请日：2001-04-09

申请人： Thomas J. Hiblar ,  Robert L. Barry ,  Edward Wulfman ,  Zihong Guo ,  Verivada Chandru Chandrasekaran

发明人： Thomas J. Hiblar ,  Robert L. Barry ,  Edward Wulfman ,  Zihong Guo ,  Verivada Chandru Chandrasekaran

IPC分类号： A61B1732

CPC分类号： A61B17/320758 ,  A61B17/320725 ,  A61B2017/320004

摘要： A rotational ablation atherectomy device including a flexible drive shaft and a compressible burr that may be inserted and extracted from a patient using a catheter having a diameter that is smaller than the operational diameter of the burr. In one embodiment, the burr includes a nose portion coupled to the drive shaft and one or more flexible abrasive disks disposed rearwardly from the nose portion. The flexible disks are foldable to be slidably received within a catheter. In another embodiment, the burr includes a support member coupled to the drive shaft, the support member having a resilient panel that spirals outwardly, forming a generally cylindrical ablation surface. The flexible panel can be elastically urged toward the support member and slidably inserted into the catheter. In a third embodiment, the burr includes a plurality of struts that are coupled to the drive shaft. An elastically compressible body disposed between the struts permits the struts to flex inwardly to reduce the burr diameter. In another embodiment, the burr includes a plurality of flexible wires attached at proximal and distal ends to the drive shaft. An abrasive sheath is disposed over the wires. The wires can be bent inwardly to compress the burr and re-expanded by rotation of the burr. In another embodiment, the burr comprises a nose portion and a resilient shell having a compressible, larger diameter abrasive section disposed at the proximal end of the nose portion.

摘要翻译： 包括柔性驱动轴和可压缩毛刺的旋转消融粥样斑块切除装置，其可以使用直径小于毛刺的操作直径的导管从患者插入和拔出。 在一个实施例中，毛刺包括联接到驱动轴的鼻部和从鼻部向后设置的一个或多个柔性研磨盘。 柔性盘可折叠成可滑动地容纳在导管内。 在另一个实施例中，毛刺包括联接到驱动轴的支撑构件，支撑构件具有向外螺旋的弹性面板，形成大致圆柱形的烧蚀表面。 柔性面板可以弹性地推向支撑构件并且可滑动地插入导管中。 在第三实施例中，毛刺包括联接到驱动轴的多个支柱。 设置在支柱之间的可弹性压缩体允许支柱向内弯曲以减小毛刺直径。 在另一个实施例中，毛刺包括在近端和远端附接到驱动轴的多个柔性线。 研磨护套设置在电线上。 电线可以向内弯曲以压缩毛刺并通过毛刺的旋转而重新膨胀。 在另一个实施例中，毛刺包括鼻部和弹性壳，弹性壳具有设置在鼻部的近端的可压缩的较大直径的研磨部。