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公开(公告)号：US20050260194A1
公开(公告)日：2005-11-24
申请号：US11029003
申请日：2005-01-05
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low , James Stattel
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low , James Stattel
IPC分类号： A61K39/395 , C07H21/04 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K16/44 , C07K16/46 , C12N5/06 , C12N9/64 , C12P21/04
CPC分类号： C07K14/505 , A61K38/00 , C07K5/0806 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/475 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/745 , C07K2319/00 , C07K2319/30 , C07K2319/43 , C07K2319/73 , C12N9/6437 , C12N9/644 , C12N9/647 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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公开(公告)号：US20050032174A1
公开(公告)日：2005-02-10
申请号：US10841250
申请日：2004-05-06
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , James Stattel , Susan Low
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , James Stattel , Susan Low
IPC分类号： A61K39/395 , C07H21/04 , C07K1/02 , C07K1/06 , C07K1/10 , C07K1/107 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K16/00 , C07K16/44 , C07K16/46 , C12N20060101 , C12N5/06 , C12N9/64 , C12P21/00 , C12P21/04
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
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公开(公告)号：US20070172928A1
公开(公告)日：2007-07-26
申请号：US11588431
申请日：2006-10-27
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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公开(公告)号：US20050281829A1
公开(公告)日：2005-12-22
申请号：US10841956
申请日：2004-05-06
申请人： Cristina Hehir , Adam Mezo , Robert Peters , James Stattel , Vito Palombella , Alan Bitonti
发明人： Cristina Hehir , Adam Mezo , Robert Peters , James Stattel , Vito Palombella , Alan Bitonti
IPC分类号： A61K38/16 , A61K39/42 , C07K14/16 , C07K16/10 , C12N20060101
CPC分类号： C07K14/005 , A61K38/162 , C07K2319/00 , C07K2319/30 , C12N2740/16122
摘要： The invention relates to anti viral agents comprised of viral fusion inhibitors and at least a portion of an immunoglobulin constant region. The invention further relates to anti viral agents comprised HIV viral fusion inhibitors and an Fc fragment of an immunoglobulin. The invention also relates to methods of treating a viral infection, including HIV infection.
摘要翻译： 本发明涉及由病毒融合抑制剂和至少一部分免疫球蛋白恒定区组成的抗病毒剂。 本发明还涉及包含HIV病毒融合抑制剂和免疫球蛋白的Fc片段的抗病毒剂。 本发明还涉及治疗包括HIV感染在内的病毒感染的方法。
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公开(公告)号：US20050027109A1
公开(公告)日：2005-02-03
申请号：US10842054
申请日：2004-05-06
申请人： Adam Mezo , Robert Peters
发明人： Adam Mezo , Robert Peters
IPC分类号： A61K39/395 , C07H21/04 , C07K1/02 , C07K1/06 , C07K1/10 , C07K1/107 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K16/00 , C07K16/44 , C07K16/46 , C12N20060101 , C12N5/06 , C12N9/64 , C12P21/00 , C12P21/04
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.
摘要翻译： 本发明提供了化学合成包含免疫球蛋白恒定区和生物活性分子的至少一部分的嵌合蛋白的方法。
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公开(公告)号：US20100310561A1
公开(公告)日：2010-12-09
申请号：US12522114
申请日：2008-06-03
申请人： Keith Canada , Uwe Schoenbeck , Eugene R. Hickey , Adam Mezo , Kevin McDonnell
发明人： Keith Canada , Uwe Schoenbeck , Eugene R. Hickey , Adam Mezo , Kevin McDonnell
IPC分类号： A61K39/395 , C07K16/00 , C07K14/00 , C12N15/12 , C12N15/63 , C12N5/00 , C12P21/00 , A61P9/00 , A61P31/04 , A61P11/00 , A61P13/12
摘要： Natriuretic peptide fusion proteins comprising natriuretic peptides linked to antibody Fc domains, nucleic acid molecules encoding the fusion proteins disclosed herein, expression vectors expressing said fusion proteins, pharmaceutical compositions comprising said fusion proteins, and methods for their therapeutic use are disclosed.
摘要翻译： 公开了包含与抗体Fc结构域连接的利尿钠肽，编码本文公开的融合蛋白的核酸分子，表达所述融合蛋白的表达载体，包含所述融合蛋白的药物组合物及其治疗用途的利钠肽融合蛋白。
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公开(公告)号：US20070254831A1
公开(公告)日：2007-11-01
申请号：US11676148
申请日：2007-02-16
申请人： Adam Mezo , Kevin McDonnell , Cristina Hehir , Alfredo Castro
发明人： Adam Mezo , Kevin McDonnell , Cristina Hehir , Alfredo Castro
CPC分类号： C07K14/70539 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/70535 , G01N2333/70535
摘要： The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.
摘要翻译： 本发明涉及结合人FcRn并抑制IgG的Fc部分与FcRn的结合的肽，从而调节血清IgG水平。 所公开的组合物和方法可用于例如治疗自身免疫性疾病和炎症性疾病。 本发明还涉及制备本发明的肽的方法和制备方法。
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