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46 条记录 (耗时 0.046 秒)

    2-cyano-3-hydroxy-enamides
    1.
    发明授权
    2-cyano-3-hydroxy-enamides 失效
    2-氰基-3-羟基 - 烯酰胺

    公开(公告)号：US5308865A

    公开(公告)日：1994-05-03

    申请号：US1564

    申请日：1993-01-06

    申请人： Robert R. Bartlett ,  David P. Kay ,  Elizabeth A. Kuo ,  Rudolf Schleyerbach ,  Wilfried Schwab

    发明人： Robert R. Bartlett ,  David P. Kay ,  Elizabeth A. Kuo ,  Rudolf Schleyerbach ,  Wilfried Schwab

    IPC分类号： A61K31/165 ,  A61K31/275 ,  A61K31/277 ,  A61P29/00 ,  C07C255/19 ,  C07C255/23 ,  C07C255/26 ,  C07C255/60 ,  C07C255/61 ,  C07C323/41 ,  C07C255/36

    CPC分类号： C07C255/19 ,  C07C255/23

    摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of ##STR2## R.sub.13, R.sub.14 and R.sub.15 are individually selected from the group consisting of hydrogen, halogen and alkyl of 1 to 3 carbon atoms, n is an integer from 1 to 3, R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms, R.sub.3, R.sub.4 R.sub.5, R.sub.6 and R.sub.7 are individually selected from the group consisting of hydrogen, halogen, --NO.sub.2, --CN, alkyl, alkylthio and alkoxy of 1 to 6 carbon atoms, alkylcarbonyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, ##STR3## m is 0, 1, 2 or 3, n is 1, 2 or 3; Hal, Hal.sub.1, Hal.sub.2 and Hal.sub.3 are individually halogen and ##STR4## R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 are individually any of the groups defined above for R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 or R.sub.4 and R.sub.5 together form --O--CH.sub.2 --O-- and their non-toxic, pharmaceutically acceptable base addition salts having anti-inflammatory activity.

    摘要翻译： 选自下列化合物的化合物的化合物其中R 1选自下组的化合物：其中R 1选自由下列组成的组：R 1，R 14和R 15分别选自氢，卤素和烷基 1至3个碳原子，n为1至3的整数，R2为氢或1至3个碳原子的烷基，R3，R4 + L，R5，R6和R7分别选自氢，卤素 ，碳原子数1〜6的烷氧基，碳原子数为2〜6的烷基羰基，碳原子数3〜6的环烷基，（CH 2）m CF 3，O（CH 2）m CF 3，S（CH 2） mCF3， m为0,1,2或3，n为1,2或3; Hal，Hal1，Hal2和Hal3分别为卤素，R8，R9，R10，R11和R12分别是R3，R4，R5，R6和R7中定义的任何基团，R4或R5一起形成-O- CH2-O-及其具有抗炎活性的无毒的药学上可接受的碱加成盐。

    Pharmaceuticals, phosphorus-containing 2-isoxazolines and isoxazoles contained therein
    3.
    发明授权
    Pharmaceuticals, phosphorus-containing 2-isoxazolines and isoxazoles contained therein 失效
    药物，其中含有含磷的2-异恶唑啉和异恶唑

    公开(公告)号：US5006515A

    公开(公告)日：1991-04-09

    申请号：US262635

    申请日：1988-10-26

    申请人： Wilfried Schwab ,  Robert R. Bartlett ,  Ulrich Gebert ,  Hans U. Schorlemmer ,  Gerhard Dickneite ,  Hans H. Sedlacek

    发明人： Wilfried Schwab ,  Robert R. Bartlett ,  Ulrich Gebert ,  Hans U. Schorlemmer ,  Gerhard Dickneite ,  Hans H. Sedlacek

    IPC分类号： A61K31/675 ,  A61K39/39 ,  A61P35/00 ,  A61P37/00 ,  C07F9/40 ,  C07F9/653 ,  C07F9/6574

    CPC分类号： C07F9/653 ,  A61K31/675

    摘要： Pharmaceuticals containing or composed of at least one compound of the formula I and/or one of its physiologically tolerated salts where appropriate, where the compounds of the formula I can, where appropriate, be in the form of pure stereoisomers or mixtures thereof; formula I is: ##STR1## in which R.sup.1 =organic radical or halogen,A=C,C single or C,C double bond,n=0, 1 or 2, and ##STR2## R.sup.2 and R.sup.3 =H or optionally substituted aliphatic radical. The pharmaceuticals are suitable for the prophylaxis and/or treatment of diseases of the immune system, especially of tumors, infections and/or autoimmune diseases of the human or animal body and for use as adjuvants for vaccines.Some of the compounds of the formula I are new; the compounds can be prepared by special processes.

    摘要翻译： 含有或由至少一种式I化合物和/或其适当的生理学耐受盐组成的药物，其中式I化合物在适当时可以是纯立体异构体或其混合物的形式; 式I是：其中R 1 =有机基团或卤素，A = C，C单或C，C双键，n = 0,1或2，X和Y =烷基或= OR 2 或具有R2和R3 = H的NR2R3或任选取代的脂族基团。 该药物适用于预防和/或治疗免疫系统疾病，特别是人或动物体的肿瘤，感染和/或自身免疫性疾病的疾病，并且可用作疫苗佐剂。 一些式I的化合物是新的; 该化合物可以通过特殊方法制备。

    Die-casting machine
    9.
    发明授权
    Die-casting machine 失效
    冲压机

    公开(公告)号：US5201358A

    公开(公告)日：1993-04-13

    申请号：US820083

    申请日：1992-01-13

    申请人： Friedrich Stummer ,  Wilfried Schwab ,  Wolfgang Schneider ,  Heike Baldering

    发明人： Friedrich Stummer ,  Wilfried Schwab ,  Wolfgang Schneider ,  Heike Baldering

    IPC分类号： B22D17/14 ,  B22D17/00 ,  B22D17/10 ,  B22D17/20 ,  B22D17/30 ,  B22D27/15

    CPC分类号： B22D17/00 ,  B22D17/10 ,  B22D17/203

    摘要： In a die-casting machine for producing castings from metals or metal alloys, which castings have a low content of gas, pores and oxides, melt is drawn by means of a vacuum out of a holding device (10) via a suction tube (11) into a casting chamber (3). A casting plunger (7) closes the inlet opening (16) to the casting chamber (3). In order to achieve as low as possible mechanical surface pressure due to flow of the melt, and fluviatile erosion of the die-side end of the inlet opening (16), and thus avoid high wear of this inlet edge or of the casting chamber with casting plunger, a planar or linear inlet cross-section (24, 27) as well as a curved deflection surface (20) on the casting plunger (7) are provided.

    摘要翻译： 在用于从金属或金属合金制造铸件的压铸机中，这些铸件具有低含量的气体，孔和氧化物，熔体通过抽吸管（11）从保持装置（10）中抽出， ）到铸造室（3）中。 铸造柱塞（7）将浇注室（3）的入口（16）封闭。 为了实现由于熔体流动而导致的机械表面压力尽可能低，以及入口开口（16）的模头侧端部的流体侵蚀，因此避免了该入口边缘或铸造室的高磨损 提供了铸造柱塞，平面或线性入口横截面（24,27）以及铸造柱塞（7）上的弯曲偏转表面（20）。