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14 条记录 (耗时 0.021 秒)

    Polynucleotide and polypeptide sequence of rabbit G-protein alpha 16
    1.
    发明授权
    Polynucleotide and polypeptide sequence of rabbit G-protein alpha 16 失效
    兔G蛋白α的多核苷酸和多肽序列16

    公开(公告)号：US06433156B1

    公开(公告)日：2002-08-13

    申请号：US09218489

    申请日：1998-12-22

    申请人： Robert S. Ames ,  John A. Feild ,  Tania Testa

    发明人： Robert S. Ames ,  John A. Feild ,  Tania Testa

    IPC分类号： C07H2104

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： Rabbit G alpha 16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rabbit G alpha 16 polypeptides and polynucleotides in screening of antagonists or agonists of cells co-expressing a G-protein coupled receptor and rabbit G alpha 16.

    摘要翻译： 公开了通过重组技术产生这种多肽的兔Gα16多肽和多核苷酸和方法。 还公开了在筛选共表达G蛋白偶联受体和兔Gα16的细胞的拮抗剂或激动剂时利用兔Gα16多肽和多核苷酸的方法。

    cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor
    2.
    发明授权
    cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor 失效
    编码新型人7-跨膜受体的cDNA克隆HMTMF81

    公开(公告)号：US06200775B1

    公开(公告)日：2001-03-13

    申请号：US09044404

    申请日：1998-03-19

    申请人： Catherine E. Ellis ,  Wendy Halsey ,  Ganesh M. Sathe ,  Robert S. Ames ,  James J. Foley ,  Henry M. Sarau ,  Jon Chambers

    发明人： Catherine E. Ellis ,  Wendy Halsey ,  Ganesh M. Sathe ,  Robert S. Ames ,  James J. Foley ,  Henry M. Sarau ,  Jon Chambers

    IPC分类号： C12N1512

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： HMTMF81 polypeptides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMTMF81 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris, myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了HMTMF81多肽和通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HMTMF81多肽和多核苷酸的方法; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛，心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    HMTF81 human 7-transmembrane receptor
    6.
    发明授权
    HMTF81 human 7-transmembrane receptor 失效
    HMTF81人7-跨膜受体

    公开(公告)号：US06506878B1

    公开(公告)日：2003-01-14

    申请号：US09586924

    申请日：2000-06-05

    申请人： Catherine E. Ellis ,  Wendy Halsey ,  Ganesh M. Sathe ,  Robert S. Ames ,  James J. Foley ,  Henry M. Sarau ,  Jon Chambers

    发明人： Catherine E. Ellis ,  Wendy Halsey ,  Ganesh M. Sathe ,  Robert S. Ames ,  James J. Foley ,  Henry M. Sarau ,  Jon Chambers

    IPC分类号： C07K14705

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： HMTMF81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMTMF81 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了HMTMF81多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HMTMF81多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    Multilead microwave connector
    7.
    发明授权
    Multilead microwave connector 失效
    多层微波连接器

    公开(公告)号：US5190462A

    公开(公告)日：1993-03-02

    申请号：US754484

    申请日：1991-09-03

    申请人： John K. Lauchner ,  Andrew J. Schlaiss ,  Robert S. Ames

    发明人： John K. Lauchner ,  Andrew J. Schlaiss ,  Robert S. Ames

    IPC分类号： H01R12/50 ,  H01R13/26 ,  H01R13/28

    CPC分类号： H01R23/6873 ,  H01R12/58 ,  H01R13/26 ,  H01R13/28 ,  H01R23/68

    摘要： An N.times.M electrical connector suitable for use at microwave frequencies comprises a first set of N insulating parallel substrates each containing M notches with adjacent planar conductors and a second set of M parallel substrates having up to N spaced-apart conductors, wherein the notch-to-notch and conductor-to-conductor spacing of the first set matches the substrate-to-substrate spacing of the second set and vice versa, so that when the second set is pushed into the notches of the first set, each notch and associated conductor on the first set aligns with related conductors on the second set of "L" shaped relation. One or more spring contacts at each intersection provide positive electrical connection between the proximate conductors. The arrangement is especially useful for microwave systems since multiple signal lines and ground planes may be connected simultaneously without interference or substantial electrical discontinuity.

    摘要翻译： 适用于微波频率的NxM电连接器包括第一组N个绝缘平行基板，每个N个绝缘平行基板包含具有相邻平面导体的M个凹口和具有多达N个间隔开的导体的第二组M个平行基板， 第一组的凹口和导体与导体之间的间距与第二组的衬底与衬底的间隔相匹配，反之亦然，从而当第二组被推入第一组的凹口时，每个凹口和相关联的导体 第一组与第二组“L”形关系的相关导体对齐。 每个交叉点处的一个或多个弹簧触点在相邻导体之间提供正电连接。 该装置对于微波系统特别有用，因为多个信号线和接地层可以同时连接而没有干扰或实质的电中断。

    Methods of screening for agonists and antagonists of the interaction between the human KIAA0001 receptor and ligands thereof
    9.
    发明授权
    Methods of screening for agonists and antagonists of the interaction between the human KIAA0001 receptor and ligands thereof 失效
    筛选人KIAA0001受体及其配体之间相互作用的激动剂和拮抗剂的方法

    公开(公告)号：US06238873B1

    公开(公告)日：2001-05-29

    申请号：US09303524

    申请日：1999-04-30

    申请人： Robert S. Ames ,  Anne Romanic Arnold ,  Jonathan K. Chambers ,  James Joseph Foley ,  Henry M. Sarau ,  Brian R. Stewart

    发明人： Robert S. Ames ,  Anne Romanic Arnold ,  Jonathan K. Chambers ,  James Joseph Foley ,  Henry M. Sarau ,  Brian R. Stewart

    IPC分类号： G01N3353

    CPC分类号： C07K14/705 ,  C07K2319/00 ,  G01N2333/726 ,  G01N2500/20

    摘要： Disclosed are methods for discovering agonists and antagonists of the interaction between UDP-glucose, UDP-galactose, UDP-glucuronic acid, UDP-N-acetyl glucosamine, as well as related UDP sugars, and their cellular receptor, human KIAA0001, which may have utility in the treatment of several human diseases and disorders, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; restenosis; atherosclerosis; diseases characterized by excessive smooth muscle cell proliferation; aneurysms; wound healing; diseases characterized by loss of smooth muscle cells or reduced smooth muscle cell proliferation; stroke; ischemia; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; degenerative diseases, such as neurodegenerative diseases and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others.

    摘要翻译： 公开了用于发现UDP-葡萄糖，UDP-半乳糖，UDP-葡糖醛酸，UDP-N-乙酰葡糖胺以及相关的UDP糖和它们的细胞受体之间的相互作用的激动剂和拮抗剂的方法，人类KIAA0001可能具有 包括但不限于：细菌，真菌，原生动物和病毒感染等感染，尤其是HIV-1或HIV-2引起的感染; 疼痛; 癌症; 糖尿病，肥胖; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 再狭窄; 动脉粥样硬化 以过度平滑肌细胞增殖为特征的疾病; 动脉瘤 伤口愈合; 特征在于平滑肌细胞丧失或平滑肌细胞增殖减少的疾病; 行程; 缺血; 溃疡 哮喘; 过敏 良性前列腺肥大; 偏头痛 呕吐 精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，抑郁症，del妄，痴呆和严重智力迟钝; 退行性疾病，如神经退行性疾病和运动障碍，如亨廷顿病或吉尔斯·德拉·图雷特综合征等。