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1.发明授权Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders 失效可用于治疗IL-5介导的疾病的重组IL-5拮抗剂公开(公告)号：US06946130B2
公开(公告)日：2005-09-20
申请号：US10700740
申请日：2003-11-04
申请人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
发明人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
CPC分类号： C07K16/244 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译： 提供衍生自高亲和力中和mAb的嵌合，人源化和其它IL-5mAb，含有其的药物组合物，治疗方法和诊断。
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2.发明授权Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders 失效可用于治疗IL-5介导的疾病的重组IL-5拮抗剂
公开(公告)号：US6129913A
公开(公告)日：2000-10-10
申请号：US637647
申请日：1997-06-19
申请人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
发明人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P37/08 , C07K14/54 , C07K14/715 , C07K16/24 , C07K16/46 , C12N5/10 , C12N15/09 , C12P21/08 , G01N33/68 , A61K39/40 , C07K16/00
CPC分类号： C07K16/244 , C07K14/5409 , C07K14/7155 , G01N33/6869 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N2799/026
摘要： Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译： PCT No.PCT / US95 / 17082 Sec。 371日期：1997年6月19日 102（e）日期1997年6月19日PCT 1995年12月22日PCT PCT。 WO96 / 21000 PCT出版物 日期1996年7月11日提供衍生自高亲和力中和mAb的混合，人源化和其它IL-5mAb，含有其的药物组合物，治疗方法和诊断。
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3.发明授权Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders 失效可用于治疗IL-5介导的疾病的重组IL-5拮抗剂
公开(公告)号：US5693323A
公开(公告)日：1997-12-02
申请号：US470110
申请日：1995-06-06
申请人： Robert S. Ames, Jr. , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
发明人： Robert S. Ames, Jr. , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
IPC分类号： A61K38/00 , C07K16/24 , A61K39/395 , C07K16/00 , C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译： 提供衍生自高亲和力中和mAb的嵌合，人源化和其它IL-5mAb，含有其的药物组合物，治疗方法和诊断。
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4.发明申请RECOMBINANT IL-5 ANTAGONISTS USEFUL IN TREATMENT OF IL-5 MEDIATED DISORDERS 失效用于治疗IL-5介导的疾病的重组IL-5拮抗剂公开(公告)号：US20100316634A1
公开(公告)日：2010-12-16
申请号：US12715043
申请日：2010-03-01
申请人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
发明人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
IPC分类号： A61K39/395 , C07K16/24 , C12N5/12 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/08 , G01N33/53 , A61P11/06 , A61P37/08 , A61P17/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译： 提供衍生自高亲和力中和mAb的嵌合，人源化和其它IL-5mAb，含有其的药物组合物，治疗方法和诊断。
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5.发明授权Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders 失效可用于治疗IL-5介导的疾病的重组IL-5拮抗剂公开(公告)号：US07982005B2
公开(公告)日：2011-07-19
申请号：US12715043
申请日：2010-03-01
申请人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
发明人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
IPC分类号： C07K1/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译： 提供衍生自高亲和力中和mAb的嵌合，人源化和其它IL-5mAb，含有其的药物组合物，治疗方法和诊断。
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6.发明申请RECOMBINANT IL-5 ANTAGONISTS USEFUL IN TREATMENT OF IL-5 MEDIATED DISORDERS 审中-公开用于治疗IL-5介导的疾病的重组IL-5拮抗剂公开(公告)号：US20090017020A1
公开(公告)日：2009-01-15
申请号：US12134619
申请日：2008-06-06
申请人： Robert S. AMES , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
发明人： Robert S. AMES , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
IPC分类号： A61K39/395 , C07K16/24 , C12N5/00 , C12N15/63 , C12N1/19 , G01N33/53 , C12P21/00 , C12N1/21 , C12N5/10 , A61P1/00 , C07H21/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译： 提供衍生自高亲和力中和mAb的嵌合，人源化和其它IL-5mAb，含有其的药物组合物，治疗方法和诊断。
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公开(公告)号：US5783184A
公开(公告)日：1998-07-21
申请号：US667769
申请日：1996-06-21
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/16 , A61P37/08 , C07K14/54 , C07K14/715 , C07K16/24 , C07K16/46 , C12N5/10 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/564 , G01N33/577 , G01N33/68 , A61K39/40 , C07K16/00
CPC分类号： G01N33/6869 , C07K14/5409 , C07K14/7155 , C07K16/244 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C12N2799/026 , G01N2333/5409 , G01N2500/02 , G01N2800/24
摘要： The present invention relates to treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs and other altered antibodies such as Fabs, chimeric, human and humanized antibodies that do not block binding of human IL-5 to the .alpha.-chain of the human IL-5 receptor.
摘要翻译： 本发明涉及治疗和诊断由IL-5和过量嗜酸性粒细胞产生介导的病症，更具体地涉及不阻断人IL-5与人IL-5结合的mAb和其他改变的抗体，例如Fab，嵌合，人和人源化抗体 人IL-5受体的α链。
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公开(公告)号：US5683892A
公开(公告)日：1997-11-04
申请号：US467420
申请日：1995-06-06
申请人： Robert S. Ames, Jr. , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
发明人： Robert S. Ames, Jr. , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
CPC分类号： C07K16/244 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： DNA encoding chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
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9.发明授权Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders 失效可用于治疗IL-5介导的疾病的重组IL-5拮抗剂公开(公告)号：US07399837B2
公开(公告)日：2008-07-15
申请号：US11076395
申请日：2005-10-20
申请人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
发明人： Robert S. Ames , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译： 提供衍生自高亲和力中和mAb的嵌合，人源化和其它IL-5mAb，含有其的药物组合物，治疗方法和诊断。
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公开(公告)号：US5851525A
公开(公告)日：1998-12-22
申请号：US940371
申请日：1997-09-30
申请人： Robert S. Ames, Jr. , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
发明人： Robert S. Ames, Jr. , Edward Robert Appelbaum , Irwin M. Chaiken , Richard M. Cook , Mitchell Stuart Gross , Stephen Dudley Holmes , Lynette Jane McMillan , Timothy Wayne Theisen
IPC分类号： A61K38/00 , C07K16/24 , A61K39/395 , C07K16/00 , C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
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