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公开(公告)号：US5604108A
公开(公告)日：1997-02-18
申请号：US253251
申请日：1994-06-02
IPC分类号： A61K49/00 , G01N33/554
CPC分类号： A61K49/00
摘要： The dosage response of humans to conjugate vaccines comprising a bacterial polysaccharide and a strongly-immunogenic carrier protein is determined in animals by coadministering to the animal unconjugated strongly-immunogenic carrier protein in an amount corresponding, on a weight-related basis, to that administered to the human.
摘要翻译： 在动物中通过将与重量相关的量对应于动物未缀合的强免疫原性载体蛋白的动物来测定人类对包含细菌多糖和强免疫原性载体蛋白的结合疫苗的剂量反应。 人类。
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公开(公告)号：US5853736A
公开(公告)日：1998-12-29
申请号：US801152
申请日：1997-02-18
申请人： Robert S. Becker , Karen Biscardi , Laura Ferguson , Lorne Erdile
发明人： Robert S. Becker , Karen Biscardi , Laura Ferguson , Lorne Erdile
IPC分类号： A61K39/00 , A61K20060101 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/38 , A61K39/39 , A61K47/48 , A61P37/04
CPC分类号： A61K39/00 , A61K39/0225 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/48369 , A61K2039/5252 , A61K2039/545 , A61K2039/55594 , A61K2039/575 , A61K2039/6018 , C12N2760/16134
摘要： An enhanced immune response to antigens, particularly normally weakly-immunogenic viral antigens, such as the HA antigen from influenza virus, is achieved by coadministering the antigen in two different physiochemical forms, particularly to enable presentation of antigen both by B cells and accessory cells.
摘要翻译： 通过以两种不同的生理化学形式组合抗原，特别是能够通过B细胞和辅助细胞呈递抗原来实现对抗原，特别是通常弱免疫原性病毒抗原（例如来自流感病毒的HA抗原）的增强的免疫应答。
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公开(公告)号：US6024963A
公开(公告)日：2000-02-15
申请号：US193682
申请日：1998-11-17
申请人： Robert S. Becker , Karen Biscardi , Laura Ferguson , Lorne Erdile
发明人： Robert S. Becker , Karen Biscardi , Laura Ferguson , Lorne Erdile
IPC分类号： A61K39/00 , A61K20060101 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/38 , A61K39/39 , A61K47/48 , A61P37/04
CPC分类号： A61K39/00 , A61K39/0225 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/48369 , A61K2039/5252 , A61K2039/545 , A61K2039/55594 , A61K2039/575 , A61K2039/6018 , C12N2760/16134
摘要： An enhanced immune response to antigens, particularly normally weakly-immunogenic viral antigens, such as the HA antigen from influenza virus, is achieved by coadministering the antigen in two different physio-chemical forms, particularly to enable presentation of antigen both by B cells and accessory cells.
摘要翻译： 通过以两种不同的生理化学形式共抗原，特别是能够通过B细胞和附属物呈递抗原来实现对抗原，特别是通常弱的免疫原性病毒抗原（例如来自流感病毒的HA抗原）的增强的免疫应答 细胞。
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公开(公告)号：US5837264A
公开(公告)日：1998-11-17
申请号：US470278
申请日：1995-06-06
申请人： Robert S. Becker , Karen Biscardi , Laura Ferguson , Lorne Erdile
发明人： Robert S. Becker , Karen Biscardi , Laura Ferguson , Lorne Erdile
IPC分类号： A61K39/00 , A61K20060101 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/38 , A61K39/39 , A61K47/48 , A61P37/04
CPC分类号： A61K39/00 , A61K39/0225 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/48369 , A61K2039/5252 , A61K2039/545 , A61K2039/55594 , A61K2039/575 , A61K2039/6018 , C12N2760/16134
摘要： An enhanced immune response to antigens, particularly normally weakly-immunogenic viral antigens, such as the HA antigen from influenza virus, is achieved by coadministering the antigen in two different physio-chemical forms, particularly to enable presentation of antigen both by B cells and accessory cells.
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公开(公告)号：US5662909A
公开(公告)日：1997-09-02
申请号：US385587
申请日：1995-02-08
申请人： Robert S. Becker , Karen Biscardi , Laura Ferguson , Lorne Erdile
发明人： Robert S. Becker , Karen Biscardi , Laura Ferguson , Lorne Erdile
IPC分类号： A61K39/00 , A61K20060101 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/38 , A61K39/39 , A61K47/48 , A61P37/04 , A61K39/295 , A61K39/002
CPC分类号： A61K39/00 , A61K39/0225 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/48369 , A61K2039/5252 , A61K2039/545 , A61K2039/55594 , A61K2039/575 , A61K2039/6018 , C12N2760/16134
摘要： An enhanced immune response to antigens, particularly normally weakly-immunogenic viral antigens, such as the HA antigen from influenza virus, is achieved by coadministering the antigen in two different physio-chemical forms, particularly to enable presentation of antigen both by B cells and accessory cells.
摘要翻译： 通过以两种不同的生理化学形式共抗原，特别是能够通过B细胞和附属物呈递抗原来实现对抗原，特别是通常弱的免疫原性病毒抗原（例如来自流感病毒的HA抗原）的增强的免疫应答 细胞。
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公开(公告)号：US20060110408A1
公开(公告)日：2006-05-25
申请号：US11173364
申请日：2005-07-01
申请人： Robert Becker , Robert Huebner , Maryann Gray , Karen Biscardi , Lorne Erdile , Bruno Guy
发明人： Robert Becker , Robert Huebner , Maryann Gray , Karen Biscardi , Lorne Erdile , Bruno Guy
CPC分类号： A61K39/0225 , A61K39/092 , A61K39/105 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/6018 , A61K2039/70 , C07K14/20 , C07K14/285 , C07K14/3156 , C12N2760/16134 , Y02A50/401 , Y10S424/828 , A61K39/102 , A61K39/09 , A61K2300/00
摘要： Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.
摘要翻译： 免疫学组成和制备和使用它们的方法。 组合物含有至少一种抗原和至少一种脂蛋白和任选的佐剂。 脂蛋白本身可以是抗原性的或免疫原性的。 抗原可以是流感HA，脂蛋白是具有用于脂质化的OspA前导物和蛋白质部分的PspA的重组表达产物。 抗原可以是OspC和脂蛋白OspA。 组合物的组分共同施用。 通过组合物和方法获得增强的免疫应答。
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公开(公告)号：US20080089911A1
公开(公告)日：2008-04-17
申请号：US11804446
申请日：2007-05-18
申请人： Robert Becker , Robert Huebner , Maryann Gray , Karen Biscardi , Lorne Erdile , Bruno Guy
发明人： Robert Becker , Robert Huebner , Maryann Gray , Karen Biscardi , Lorne Erdile , Bruno Guy
CPC分类号： A61K39/0225 , A61K39/092 , A61K39/105 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/6018 , A61K2039/70 , C07K14/20 , C07K14/285 , C07K14/3156 , C12N2760/16134 , Y02A50/401 , Y10S424/828 , A61K39/102 , A61K39/09 , A61K2300/00
摘要： Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.
摘要翻译： 免疫学组成和制备和使用它们的方法。 组合物含有至少一种抗原和至少一种脂蛋白和任选的佐剂。 脂蛋白本身可以是抗原性的或免疫原性的。 抗原可以是流感HA，脂蛋白是具有用于脂质化的OspA前导物和蛋白质部分的PspA的重组表达产物。 抗原可以是OspC和脂蛋白OspA。 组合物的组分共同施用。 通过组合物和方法获得增强的免疫应答。
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