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    Internet-based shared file service with native PC client access and semantics
    1.
    发明授权
    Internet-based shared file service with native PC client access and semantics 有权
    基于Internet的共享文件服务，具有本机PC客户端访问和语义

    公开(公告)号：US07058696B1

    公开(公告)日：2006-06-06

    申请号：US09703884

    申请日：2000-11-01

    申请人： Robert S. Phillips ,  Scott H. Davis ,  Daniel J. Dietterich ,  Scott E. Nyman ,  David Porter

    发明人： Robert S. Phillips ,  Scott H. Davis ,  Daniel J. Dietterich ,  Scott E. Nyman ,  David Porter

    IPC分类号： G06F15/16

    CPC分类号： G06F17/30067 ,  G06F17/30861

    摘要： A multi-user file storage service and system enables each user of a user group to operate an arbitrary client node at an arbitrary geographic location to communicate with a remote file server node via a wide area network. More than one user of the user group is permitted to access the file group at the remote file server node simultaneously, but the integrity of the files is maintained by controlling access so that each access to one of the files at the remote file server is performed, if at all, on a respective portion of that file as most recently updated at the remote file server node.

    摘要翻译： 多用户文件存储服务和系统使得用户组的每个用户能够操作任意地理位置处的任意客户端节点，以经由广域网与远程文件服务器节点进行通信。 允许用户组的多个用户同时访问远程文件服务器节点上的文件组，但是通过控制访问来维护文件的完整性，以便执行对远程文件服务器中的一个文件的每次访问 （如果有的话）在远程文件服务器节点上最近更新的文件的相应部分上。

    Internet-based shared file service with native PC client access and semantics and distributed access control
    2.
    发明授权
    Internet-based shared file service with native PC client access and semantics and distributed access control 有权
    基于Internet的共享文件服务，具有本机PC客户端访问和语义以及分布式访问控制

    公开(公告)号：US07136903B1

    公开(公告)日：2006-11-14

    申请号：US09704050

    申请日：2000-11-01

    申请人： Robert S. Phillips ,  Scott H. Davis ,  Daniel J. Dietterich ,  Scott E. Nyman ,  David Porter

    发明人： Robert S. Phillips ,  Scott H. Davis ,  Daniel J. Dietterich ,  Scott E. Nyman ,  David Porter

    IPC分类号： G06F15/16 ,  G06F15/167 ,  G06F7/00 ,  H04L9/00

    CPC分类号： G06F17/30067 ,  G06F17/30861

    摘要： A multi-user file storage service and system enable each user of a pre-subscribed user group to communicate with a remote file server node via a wide area network and to access the files of the file group via the respective client node. More than one user of the pre-subscribed user group is permitted to access the file group at the remote file server node simultaneously. Integrity of the files at the remote file server node are maintained by controlling each access to each file at the remote file server node so that each access to files at the remote file server is performed, if at all, on a respective portion of each file as most recently updated at the remote file server node. Additionally, an encrypted key is transferred from the file server node to a particular client node via a secure channel. The encrypted key uses an encryption function and a decryption function not known locally at the remote file server. Furthermore, both privileged access control rights and file sharing mode access control to a particular file of the group of files are delegated to one or more distributed nodes other than the remote file server node which provides the data.

    摘要翻译： 多用户文件存储服务和系统使得预订用户组的每个用户能够经由广域网与远程文件服务器节点通信，并且经由相应的客户端节点访问文件组的文件。 允许预订用户组的多个用户同时访问远程文件服务器节点上的文件组。 通过控制对远程文件服务器节点上每个文件的访问来维护远程文件服务器节点上的文件的完整性，以便在每个文件的相应部分执行对远程文件服务器上的文件的每次访问 最近在远程文件服务器节点更新。 此外，加密密钥通过安全信道从文件服务器节点传送到特定的客户端节点。 加密密钥使用在远程文件服务器本地不知道的加密功能和解密功能。 此外，对提供数据的远程文件服务器节点以外的一个或多个分布式节点，委托给该组文件的特定文件的特权访问控制权和文件共享模式访问控制。

    Inhibitors of kynureninase
    7.
    发明授权
    Inhibitors of kynureninase 失效
    犬尿蛋白酶抑制剂

    公开(公告)号：US5442104A

    公开(公告)日：1995-08-15

    申请号：US184788

    申请日：1994-01-21

    申请人： Robert S. Phillips ,  Rajesh K. Dua

    发明人： Robert S. Phillips ,  Rajesh K. Dua

    IPC分类号： A01N37/44 ,  A01N41/10 ,  A61K31/195 ,  A61K31/66 ,  A61P25/00 ,  A61P25/08 ,  A61P43/00 ,  C07C229/22 ,  C07C313/06 ,  C07C317/48 ,  C07C323/58 ,  C07F9/30 ,  C07F9/36 ,  C07C317/10 ,  C07C317/14 ,  C07C317/28

    CPC分类号： A61K31/66 ,  A61K31/195 ,  C07C317/48 ,  C07C323/58

    摘要： The present invention provides inhibitors of kynureninase having the formula ##STR1## where X is CHOH, S, SO.sub.2, SO, SONH.sub.2, PO.sub.2 H or PONH.sub.2, R.sub.a and R.sub.b, independently of one another are H, a halogen, CF.sub.3 or a small alkyl group having one to three carbon atoms; R.sub.1 is H, NH.sub.2, NR.sub.6 RT, NO.sub.2, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms, wherein: R.sub.6 and R.sub.7, independently of one another, are H, a formyl group or a small alkyl group having from one to three carbon atoms with the exception that only one of R.sub.6 or R.sub.7 can be a formyl group; R.sub.2 is OH, H, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms; and R.sub.3, R.sub.4 and R.sub.5, independently of one another, are H, halogen, CF.sub.3, NO.sub.2, NH.sub.2, or small alkyl group having from one to three carbon atoms. In particular, compounds of this formula in which X is CHOH, S or SO.sub.2 are provided. In compounds of this formula in which X is CHOH, those having the (.alpha.S,.gamma.S) configuration or the (.alpha.R,.gamma.R) configuration when R.sub.A or R.sub.B is a hydrogen, are more potent inhibitors of kynureninase. Inhibitors of mammalian kynureninase are of particular use in therapy for certain neurological disorders.

    摘要翻译： 本发明提供具有式“IMAGE”的犬尿胆碱酯酶抑制剂，其中X为CHOH，S，SO2，SO，SONH2，PO2H或PONH2，Ra和Rb，彼此独立地为H，卤素，CF3或小烷基 具有一至三个碳原子; R1是H，NH2，NR6RT，NO2，卤素，CF3或具有1-3个碳原子的小烷基，其中：R6和R7彼此独立地是H，甲酰基或具有 一至三个碳原子，只有R6或R7中只有一个可以是甲酰基; R2是OH，H，卤素，CF3或具有1-3个碳原子的小烷基; R 3，R 4和R 5彼此独立地是H，卤素，CF 3，NO 2，NH 2或具有1至3个碳原子的小烷基。 特别地，提供了其中X是CHOH，S或SO 2的该式的化合物。 在其中X是CHOH的该式的化合物中，当RA或RB是氢时，具有（αS，γS）构型或（αR，γR）构型的那些化合物是更有效的犬尿胆碱酶抑制剂。 哺乳动物犬尿胆碱酶的抑制剂在某些神经障碍的治疗中特别有用。

    Pump assembly method with a tubular bypass liner
    9.
    发明授权
    Pump assembly method with a tubular bypass liner 失效
    泵组装方法用管状旁通管

    公开(公告)号：US5782615A

    公开(公告)日：1998-07-21

    申请号：US623598

    申请日：1996-03-28

    申请人： Bruce C. Noah ,  Robert S. Phillips ,  Frederick D. Venable

    发明人： Bruce C. Noah ,  Robert S. Phillips ,  Frederick D. Venable

    IPC分类号： F01C21/10 ,  F04C14/26 ,  F04C15/06 ,  F04B49/02

    CPC分类号： F04C15/06 ,  F01C21/10 ,  F04C14/26 ,  F04C2230/60 ,  Y10T29/49236

    摘要： A pump assembly (20) includes a rotor (40) and a stator (38) which are disposed within a housing (24) and partially define pumping chambers (56). Fluid is conducted through an inlet passage (104) to an inlet cavity (58) which is connected with the pumping chambers (56). Fluid is conducted from the pumping chambers (56) to an outlet (62) from the pump assembly (20). A tubular passage liner (112) is disposed in the inlet passage (104) and has a straight passage (138) through which fluid flow is conducted to the inlet cavity (58). The tubular passage liner (112) prevents erosion of the housing (24) during conduction through the inlet passage (104) of inlet fluid and fluid bypassed from the outlet (62) of the pump assembly (20). Projections (204 and 206) at one end of the tubular passage liner (112) are engageable with the stator (38) to limit movement of the tubular passage liner relative to the stator. The tubular passage liner (112) is installed in the inlet passage (104) by first closing a slot (180) to reduce the cross-sectional size of the tubular passage liner. The tubular passage liner (112) is then inserted into the inlet passage (104). The slot (180) is then opened to increase the size of the tubular passage liner (112).

    摘要翻译： 泵组件（20）包括转子（40）和定子（38），它们设置在壳体（24）内并且部分地限定泵送室（56）。 流体通过入口通道（104）传导到与泵送室（56）连接的入口腔（58）。 流体从泵室（56）传导到来自泵组件（20）的出口（62）。 管状通道衬套（112）设置在入口通道（104）中并且具有直流通道（138），流体流动通过入口腔（58）传导。 管状通道衬垫（112）防止在通过入口流体的入口通道（104）和从泵组件（20）的出口（62）旁路的流体的导电期间壳体（24）的侵蚀。 管状通道衬套（112）的一端的突出部（204和206）可与定子（38）接合，以限制管状通道衬套相对于定子的运动。 管状通道衬套（112）通过首先关闭狭槽（180）而安装在入口通道（104）中，以减小管状通道衬套的横截面尺寸。 然后将管状通道衬套（112）插入入口通道（104）中。 然后打开狭槽（180）以增加管状通道衬垫（112）的尺寸。

    Inhibitors of kynureninase
    10.
    发明授权
    Inhibitors of kynureninase 失效
    犬尿蛋白酶抑制剂

    公开(公告)号：US5495044A

    公开(公告)日：1996-02-27

    申请号：US145074

    申请日：1993-10-29

    申请人： Robert S. Phillips ,  Lakshmi V. Cyr

    发明人： Robert S. Phillips ,  Lakshmi V. Cyr

    IPC分类号： A61K31/195 ,  A61K31/66 ,  C07C229/36 ,  C07C317/48 ,  C07C323/58

    CPC分类号： A61K31/195 ,  A61K31/66 ,  C07C229/36 ,  C07C317/48 ,  C07C323/58

    摘要： The present invention provides inhibitors of kynureninase having the formula ##STR1## where X is CO or CHOH; R.sub.A and R.sub.B, independently of one another, are H, a halogen, a halovinyl group, or a small alkyl or haloalkyl group having one to three carbon atoms; A is a H or an acetyl group; R.sub.1 is H, NH.sub.2, NR.sub.6 R.sub.7, NO.sub.2, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms, wherein: R.sub.6 and R.sub.7, independently of one another, are H, a formyl group or a small alkyl group having from one to three carbon atoms with the exception that only one of R.sub.6 or R.sub.7 can be a formyl group; R.sub.2 is OH, H, halogen, CF.sub.3 or a small alkyl group having from one to three carbon atoms; and R.sub.3, R.sub.4 and R.sub.5, independently of one another, are H, halogen, CF.sub.3, NO.sub.2, NH.sub.2, or small alkyl group having from one to three carbon atoms, and with the proviso that when X=CO, neither R.sub.A nor R.sub.B can be CF.sub.3. In compounds of this formula in which X is CHOH, those having the (.alpha.S,.gamma.S) configuration or the (.alpha.R,.gamma.R) configuration when R.sub.A or R.sub.B is a hydrogen, are more potent inhibitors of kynureninase. Inhibitors of mammalian kynureninase are of particular use in therapy for certain neurological disorders.

    摘要翻译： 本发明提供了具有式“IMAGE”的犬尿胆碱酯酶的抑制剂，其中X是CO或CHOH; RA和RB彼此独立地是H，卤素，卤代乙烯基或具有1-3个碳原子的小烷基或卤代烷基; A是H或乙酰基; R 1是H，NH 2，NR 6 R 7，NO 2，卤素，CF 3或具有1至3个碳原子的小烷基，其中：R 6和R 7彼此独立地是H，甲酰基或具有 一至三个碳原子，只有R6或R7中只有一个可以是甲酰基; R2是OH，H，卤素，CF3或具有1-3个碳原子的小烷基; 和R 3，R 4和R 5彼此独立地是H，卤素，CF 3，NO 2，NH 2或具有1至3个碳原子的小烷基，条件是当X = CO时，RA和RB都不能 是CF3。 在其中X是CHOH的该式的化合物中，当RA或RB是氢时，具有（αS，γS）构型或（αR，γR）构型的那些化合物是更有效的犬尿胆碱酶抑制剂。 哺乳动物犬尿胆碱酶的抑制剂在某些神经障碍的治疗中特别有用。