公开(公告)号：US20090263411A1

公开(公告)日：2009-10-22

申请号：US12383449

申请日：2009-03-24

申请人： Roberto A. Macina ,  Leah R. Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

发明人： Roberto A. Macina ,  Leah R. Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

IPC分类号： A61K39/00 ,  C12N15/11 ,  C12Q1/68 ,  C12N15/00 ,  C12N1/21 ,  C12P21/02 ,  C07K14/00 ,  C07K16/18

CPC分类号： C07K14/82 ,  C07K14/47 ,  G01N33/57449

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

公开(公告)号：US08460880B2

公开(公告)日：2013-06-11

申请号：US12383449

申请日：2009-03-24

申请人： Roberto A. Macina ,  Leah R. Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

发明人： Roberto A. Macina ,  Leah R. Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

IPC分类号： G01N33/53

CPC分类号： C07K14/82 ,  C07K14/47 ,  G01N33/57449

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

公开(公告)号：US20070154886A1

公开(公告)日：2007-07-05

申请号：US10537743

申请日：2003-12-08

申请人： Roberto Macina ,  Leah Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

发明人： Roberto Macina ,  Leah Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C07K14/82 ,  C07K14/47 ,  G01N33/57449

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

公开(公告)号：US20060078913A1

公开(公告)日：2006-04-13

申请号：US11183261

申请日：2005-07-15

申请人： Roberto Macina ,  Leah Turner ,  Steffan Vartanian ,  Shu-Hui Liu ,  Maria Rodriguez ,  Huei-Mei Chen

发明人： Roberto Macina ,  Leah Turner ,  Steffan Vartanian ,  Shu-Hui Liu ,  Maria Rodriguez ,  Huei-Mei Chen

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C07K14/4748 ,  G01N33/57484

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, intestine and colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, intestine and colon, lung, ovarian or prostate, identifying breast, intestine and colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast, intestine and colon, lung, ovarian or prostate tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括在乳腺，肠和结肠，肺，卵巢或前列腺中识别，诊断，监测，分期，成像和治疗乳腺，肠和结肠，肺，卵巢或前列腺癌和非癌性疾病状态，鉴定乳腺，肠和 结肠，肺，卵巢或前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的产生以及工程乳房，肠和结肠，肺，卵巢或前列腺组织的生产用于治疗和研究。

公开(公告)号：US20050272067A1

公开(公告)日：2005-12-08

申请号：US11077386

申请日：2005-03-10

申请人： Roberto Macina ,  Leah Turner ,  Huei-Mei Chen ,  Maria Rodriguez ,  Shu-Hui Liu

发明人： Roberto Macina ,  Leah Turner ,  Huei-Mei Chen ,  Maria Rodriguez ,  Shu-Hui Liu

IPC分类号： C07H21/04 ,  C07K14/47 ,  C07K14/82 ,  C12N15/09 ,  C12Q1/68

CPC分类号： C07K14/4748

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, intestine and colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, intestine and colon, lung, ovarian or prostate, identifying breast, intestine and colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast, intestine and colon, lung, ovarian or prostate tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括在乳腺，肠和结肠，肺，卵巢或前列腺中识别，诊断，监测，分期，成像和治疗乳腺，肠和结肠，肺，卵巢或前列腺癌和非癌性疾病状态，鉴定乳腺，肠和 结肠，肺，卵巢或前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的产生以及工程乳房，肠和结肠，肺，卵巢或前列腺组织的生产用于治疗和研究。

公开(公告)号：US09469499B1

公开(公告)日：2016-10-18

申请号：US14967401

申请日：2015-12-14

申请人： Huei-Mei Chen

发明人： Huei-Mei Chen

IPC分类号： B65H75/44 ,  B65H75/48 ,  H04M1/04 ,  H04B1/3888 ,  H01R13/72

CPC分类号： B65H75/4471 ,  B65H75/4434 ,  B65H75/48 ,  B65H2701/3919 ,  H01R13/72 ,  H04B1/3888 ,  H04M1/04 ,  H04M1/15

摘要： A retractable cable combined with a smartphone/tablet holder contains: a roller and a removable support connected with the roller, and the roller includes a casing, a rotatable disc, a spiral torsion spring, and a data transfer cable. The casing includes a first cover and a second cover which are connected together to define an accommodation space so as to house the rotatable disc in which the spiral torsion spring is fixed, and the data transfer cable inserts through and rolls on the rotatable disc. A USB plug of the data transfer cable is accommodated beside a connecting piece of the first cover, and a terminal portion of the data transfer cable is housed on a second joining sheet of the second cover. Preferably, the terminal portion of the data transfer cable matches with a USB slot of a smartphone or a tablet.

摘要翻译： 与智能电话/平板电脑架组合的可伸缩电缆包括：一个辊子和一个与该滚筒相连的可拆卸的支架，该滚筒包括一个外壳，一个可旋转盘，一个螺旋扭转弹簧和一个数据传输电缆。 壳体包括连接在一起以限定容纳空间的第一盖和第二盖，以容纳螺旋扭转弹簧固定在其中的可旋转盘，并且数据传输电缆插入并在可旋转盘上滚动。 数据传送电缆的USB插头容纳在第一盖的连接件的旁边，数据传送电缆的端子部分容纳在第二盖的第二接合片上。 优选地，数据传输电缆的终端部分与智能电话或平板电脑的USB插槽相匹配。

公开(公告)号：US06753154B1

公开(公告)日：2004-06-22

申请号：US09344624

申请日：1999-06-25

申请人： Huei-Mei Chen ,  Mina Bissell

发明人： Huei-Mei Chen ,  Mina Bissell

IPC分类号： G01N33574

CPC分类号： C07K14/4703 ,  C12Q1/6886 ,  C12Q2600/112

摘要： A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of malignancy progression and tumorigenicity reversion. Identification, isolation and characterization of AZU-1 and AZU-2 genes localized to a tumor suppressive locus at chromosome 10q26, highly expressed in nonmalignant and premalignant cells derived from a human breast tumor progression model. A recombinant full length protein sequences encoded by the AZU-1 gene and nucleotide sequences of AZU-1 and AZU-2 genes and variant and fragments thereof. Monoclonal or polyclonal antibodies specific to AZU-1, AZU-2 encoded protein and to AZU-1, or AZU-2 encoded protein homologs.

摘要翻译： 人类AZU-1基因，突变体，变体和片段。 由AZU-1基因编码的蛋白质产物和由作为肿瘤抑制因子或恶性肿瘤进展和致瘤性逆转的标志物的AZU-1基因的变体编码的同源物。 鉴定，分离和鉴定AZU-1和AZU-2基因，其位于染色体10q26上的肿瘤抑制基因座，在来自人乳腺肿瘤进展模型的非恶性和恶化前细胞中高度表达。 由AZU-1基因编码的重组全长蛋白质序列和AZU-1和AZU-2基因的核苷酸序列及其变体和片段。 对AZU-1，AZU-2编码蛋白和AZU-1或AZU-2编码的蛋白同源物特异性的单克隆或多克隆抗体。

公开(公告)号：US20090127892A1

公开(公告)日：2009-05-21

申请号：US11943588

申请日：2007-11-21

申请人： Huei-Mei Chen

发明人： Huei-Mei Chen

IPC分类号： A47C13/00

CPC分类号： A47C13/00

摘要： A chair capable of being adjusted as a chaise comprises a cushion assembly including a first cushion, a second cushion and a third cushion; a first rotary shaft being used to pivotally connect the first cushion and the second cushion; a second rotary shaft being used to pivotally connect the second cushion and the third cushion; an adjusting unit installed below the first cushion; a chair support structure being installed between the first cushion, a second cushion and a third cushion; the chair support structure including an assisting support frame and a support frame; the assisting support frame installed between the first cushion and the third cushion; and the support frame being installed below the third cushion.

摘要翻译： 能够被调节为躺椅的椅子包括：缓冲组件，包括第一缓冲垫，第二缓冲垫和第三垫子; 用于枢转地连接第一垫和第二垫的第一旋转轴; 用于枢转地连接第二垫和第三垫的第二旋转轴; 安装在第一垫子下方的调节单元; 椅子支撑结构安装在第一垫子，第二垫子和第三垫子之间; 所述椅子支撑结构包括辅助支撑框架和支撑框架; 所述辅助支撑框架安装在所述第一垫和所述第三垫之间; 并且支撑框架安装在第三垫子的下方。

公开(公告)号：US4505936A

公开(公告)日：1985-03-19

申请号：US532179

申请日：1983-09-14

申请人： Samuel P. Meyers ,  Huei-Mei Chen

发明人： Samuel P. Meyers ,  Huei-Mei Chen

IPC分类号： A23K1/10 ,  A23K1/16 ,  A23L1/326 ,  A22C29/02

CPC分类号： A23K20/179 ,  A23K10/22 ,  A23L17/10

摘要： A novel process for the more efficient extraction with an edible oil of the red carotenoid pigment astaxanthin, from the chitinous shells and proteinaceous tissues of shellfish to provide an astaxanthin enriched dietary food ingredient, and other food products. A crustacean waste, e.g. a crawfish waste, is ground in an attrition mill to separate the soft proteinaceous tissue from the chitinous shell, the chitinous shell is removed, and the separated proteinaceous tissue is acidified to pH ranging from about 4 to 5.5 sufficient to suppress microbial degradation and improve overall pigment recovery. The acidified proteinaceous tissue is cooked, as a puree, in a kettle and extracted with certain edible oils at critical concentrations, at specified critical temperature-time relationships. The cooked product is centrifuged in a decanter centrifuge to provide two effluent streams: (a) an aqueous effluent which is separated in a three-phase separator (liquid-liquid-solid) to provide an astaxanthin enriched oil, a flavored water extract and demineralized solids, and (b) a demineralized solids effluent. The demineralized solids from both (a) and (b), the astaxanthin enriched oil, and the flavored water extract are useful as food supplements.

摘要翻译： 一种利用红色类胡萝卜素颜料虾青素食用油，贝壳类壳蛋白质和蛋白质组织提供更有效提取虾青素的新方法，提供富含虾青素的膳食食品成分及其他食品。 甲壳类废物，例如 将一个小龙虾废物在磨碎机中磨碎，以将软蛋白质组织与几丁质壳分离，除去几丁质壳，将分离的蛋白质组织酸化至约4至5.5的pH以足以抑制微生物降解并改善整体 颜料回收。 将酸化的蛋白质组织作为泥浆在釜中煮熟，并在特定临界温度 - 时间关系下用临界浓度的某些食用油提取。 煮熟的产品在倾析塔离心机中离心以提供两个流出物流：（a）在三相分离器（液 - 液 - 固）中分离出的含水流出液，以提供富含虾青素的油，调味水提取物和软化矿物质 固体，和（b）软化固体流出物。 （a）和（b）的脱矿质固体，富含虾青素的油和调味水提取物可用作食品添加剂。