Model-based positional estimation method
    2.
    发明授权
    Model-based positional estimation method 有权
    基于模型的位置估计方法

    公开(公告)号:US08744819B2

    公开(公告)日:2014-06-03

    申请号:US12987362

    申请日:2011-01-10

    Abstract: A model-based method is described which defines a rigid transformation between two co-ordinate systems that reduces the accuracy requirements on the quality of the data-set (including, but not restricted to, the error in the acquisition process, and the number and spread of the points) measured in one of the two co-ordinate systems by identifying a set of remote correspondences that are used to bind the convergence process. The method can be used in minimal-access orthopaedic surgery to improve the accuracy of limb registration. Specific instances include femoral registration, by estimating the functional center of the hip joint in both co-ordinate systems to be co-registered, and tibial registration, using the ankle center as a distant set of paired correspondences. Accuracy can be measured in a variety of ways, including, but not restricted to, evaluating the mis-alignment between the two co-registered objects.

    Abstract translation: 描述了基于模型的方法,其定义了两个坐标系之间的刚性变换,其降低了对数据集的质量的准确性要求(包括但不限于采集过程中的误差,以及数量和 通过识别用于绑定收敛过程的一组远程通信,在两个坐标系统之一中测量的点的分布)。 该方法可用于最小限度的矫形手术,以提高肢体对位的准确性。 具体实例包括股骨注册,通过估计要共同登记的两个坐标系统中的髋关节的功能中心,以及使用脚踝中心作为远处一对对应的胫骨登记。 可以以各种方式测量精度,包括但不限于评估两个共同注册物体之间的错配。

    Benzodioxole piperazine compounds
    3.
    发明授权
    Benzodioxole piperazine compounds 失效
    苯并二恶醇哌嗪化合物

    公开(公告)号:US08722683B2

    公开(公告)日:2014-05-13

    申请号:US13370345

    申请日:2012-02-10

    Abstract: The present invention is concerned with novel dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein n, Y, R1, R2, R3, and R4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions containing them and their use as pharmaceutical agents.

    Abstract translation: 本发明涉及式(I)的5-HT2A和D3受体的新型双重调节剂,其中n,Y,R 1,R 2,R 3和R 4如本文所述,以及其药学上可接受的盐和酯。 此外,本发明涉及制备式(I)化合物,含有它们的药物组合物及其作为药剂的用途。

    Anellated pyridine compounds
    6.
    发明授权
    Anellated pyridine compounds 失效
    茴香化合物

    公开(公告)号:US08470828B2

    公开(公告)日:2013-06-25

    申请号:US13171499

    申请日:2011-06-29

    CPC classification number: C07D495/04 C07D491/048

    Abstract: The present invention is concerned with novel dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein X, Y, A, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as therapeutics.

    Abstract translation: 本发明涉及式(I)的5-HT2A和D3受体的新型双重调节剂,其中X,Y,A,R 1,R 2和R 3如本文所述,以及其药学上可接受的盐和酯。 此外,本发明涉及制备式(I)化合物,包含它们的药物组合物及其作为治疗剂的用途。

    Structural Health Monitoring System
    7.
    发明申请
    Structural Health Monitoring System 有权
    结构健康监测系统

    公开(公告)号:US20120203474A1

    公开(公告)日:2012-08-09

    申请号:US13226199

    申请日:2011-09-06

    Abstract: The present invention relates to a structural health monitoring system, for example a system used in the non-destructive evaluation of an aircraft structure. The present invention provides a method and apparatus for evaluating one or more anomalies within a structure using a structural health monitoring system that includes at least three transducers arranged in operative contact with the structure such that no two transducers are aligned to be parallel. A transducer excites an elastic wave that propagates through the structure, and reflections from any anomalies within the structure are collected by the three transducers. These collected signals are analysed to identify an anomaly within the structure. Time of flight techniques are used to determine the location of the anomaly.

    Abstract translation: 本发明涉及一种结构健康监测系统,例如用于飞机结构的非破坏性评估的系统。 本发明提供一种用于使用结构健康监测系统评估结构内的一个或多个异常的方法和装置,所述结构健康监测系统包括布置成与所述结构有效接触的至少三个换能器,使得没有两个换能器对齐成平行。 传感器激发通过结构传播的弹性波,并且由三个换能器收集结构内任何异常的反射。 分析这些收集的信号以识别结构内的异常。 飞行时间技术用于确定异常的位置。

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