公开(公告)号：US20090263411A1

公开(公告)日：2009-10-22

申请号：US12383449

申请日：2009-03-24

申请人： Roberto A. Macina ,  Leah R. Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

发明人： Roberto A. Macina ,  Leah R. Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

IPC分类号： A61K39/00 ,  C12N15/11 ,  C12Q1/68 ,  C12N15/00 ,  C12N1/21 ,  C12P21/02 ,  C07K14/00 ,  C07K16/18

CPC分类号： C07K14/82 ,  C07K14/47 ,  G01N33/57449

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

公开(公告)号：US08460880B2

公开(公告)日：2013-06-11

申请号：US12383449

申请日：2009-03-24

申请人： Roberto A. Macina ,  Leah R. Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

发明人： Roberto A. Macina ,  Leah R. Turner ,  Yongming Sun ,  Shu-Hui Liu ,  Huei-Mei Chen

IPC分类号： G01N33/53

CPC分类号： C07K14/82 ,  C07K14/47 ,  G01N33/57449

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

公开(公告)号：US07678889B2

公开(公告)日：2010-03-16

申请号：US10523834

申请日：2003-08-06

申请人： Roberto A. Macina ,  Susana Salceda ,  Chenghua Liu ,  Yongming Sun ,  Leah R. Turner

发明人： Roberto A. Macina ,  Susana Salceda ,  Chenghua Liu ,  Yongming Sun ,  Leah R. Turner

IPC分类号： C07K16/00

CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括在卵巢中识别，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

公开(公告)号：US06846650B2

公开(公告)日：2005-01-25

申请号：US10002344

申请日：2001-10-25

申请人： Herve E. Recipon ,  Yongming Sun ,  Sei-Yu Chen ,  Chenghua Liu ,  Leah R. Turner

发明人： Herve E. Recipon ,  Yongming Sun ,  Sei-Yu Chen ,  Chenghua Liu ,  Leah R. Turner

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61P11/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566 ,  G01N33/574 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

公开(公告)号：US20110189679A1

公开(公告)日：2011-08-04

申请号：US12880032

申请日：2010-09-10

申请人： Nurith Kurn ,  Shenglong Wang ,  Leah R. Turner ,  Victor Sementchenko

发明人： Nurith Kurn ,  Shenglong Wang ,  Leah R. Turner ,  Victor Sementchenko

IPC分类号： C12P19/34 ,  C12Q1/68

CPC分类号： C12P19/34 ,  C12N15/1096 ,  C12Q1/6806 ,  C12Q1/6848 ,  C12Q1/6853 ,  C12Q2525/121 ,  C12Q2525/179

摘要： The present invention provides methods and compositions, including kits, for the generation of cDNA from mRNA with reduced ribosomal RNA representation.

摘要翻译： 本发明提供了用于从具有减少的核糖体RNA表示的mRNA产生cDNA的方法和组合物，包括试剂盒。