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1.发明申请OXAZOLIDIN-2-ONE-PYRIMIDINE DERIVATIVES AND THE USE THEREOF AS PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS 审中-公开氧杂环丁烷-2-酮嘧啶衍生物及其作为磷酸胆碱-3-激酶抑制剂的用途公开(公告)号：US20160168145A1
公开(公告)日：2016-06-16
申请号：US15047574
申请日：2016-02-18
申请人： Robin Alec Fairhurst , Pascal Furet , Frank Stephen Kalthoff , Andreas Lerchner , Heinrich Rueeger
发明人： Robin Alec Fairhurst , Pascal Furet , Frank Stephen Kalthoff , Andreas Lerchner , Heinrich Rueeger
IPC分类号： C07D417/14 , A61K31/5377
CPC分类号： C07D417/14 , A61K31/5377 , A61K45/06 , C07D413/14
摘要： The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.
摘要翻译： 本发明涉及作为PI3K（磷脂酰肌醇-3-激酶）抑制剂的恶唑烷-2-酮取代的嘧啶化合物及其药物组合物，其制备方法和用于治疗依赖于 PI3K。
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公开(公告)号：US20140135330A1
公开(公告)日：2014-05-15
申请号：US14069400
申请日：2013-11-01
申请人： Robin Alec Fairhurst , Pascal Furet , Frank Stephan Kalthoff , Andreas Lerchner , Heinrich Rueeger
发明人： Robin Alec Fairhurst , Pascal Furet , Frank Stephan Kalthoff , Andreas Lerchner , Heinrich Rueeger
IPC分类号： C07D413/14 , A61K31/5377 , A61K45/06 , C07D417/14
CPC分类号： C07D417/14 , A61K31/5377 , A61K45/06 , C07D413/14
摘要： The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.
摘要翻译： 本发明涉及作为PI3K（磷脂酰肌醇-3-激酶）抑制剂的恶唑烷-2-酮取代的嘧啶化合物及其药物组合物，其制备方法和用于治疗依赖于 PI3K。
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3.发明授权Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases 有权恶唑烷-2-酮嘧啶衍生物及其用于治疗依赖于PI3激酶的病症，疾病和病症的用途公开(公告)号：US09296733B2
公开(公告)日：2016-03-29
申请号：US14069400
申请日：2013-11-01
申请人： Robin Alec Fairhurst , Pascal Furet , Frank Stephan Kalthoff , Andreas Lerchner , Heinrich Rueeger
发明人： Robin Alec Fairhurst , Pascal Furet , Frank Stephan Kalthoff , Andreas Lerchner , Heinrich Rueeger
IPC分类号： A61K31/5377 , C07D413/14 , A61K45/06 , C07D417/14
CPC分类号： C07D417/14 , A61K31/5377 , A61K45/06 , C07D413/14
摘要： The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.
摘要翻译： 本发明涉及作为PI3K（磷脂酰肌醇-3-激酶）抑制剂的恶唑烷-2-酮取代的嘧啶化合物及其药物组合物，其制备方法和用于治疗依赖于 PI3K。
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公开(公告)号：US09334271B2
公开(公告)日：2016-05-10
申请号：US14353950
申请日：2012-10-26
申请人： Emmanuelle Briard , Pascal Furet , Andreas Lerchner , Peter Meier , Branko Radetich , David Andrew Sandham , Yanyi Zhu
发明人： Emmanuelle Briard , Pascal Furet , Andreas Lerchner , Peter Meier , Branko Radetich , David Andrew Sandham , Yanyi Zhu
IPC分类号： C07D487/04 , C07D473/16 , C07D519/00 , A61K31/5377 , A61K31/553 , C07D491/048 , C07D491/107
CPC分类号： C07D473/16 , A61K31/5377 , A61K31/553 , C07D487/04 , C07D491/048 , C07D491/107 , C07D519/00
摘要： The invention relates to PI3K inhibitors of the formula (I)• in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.
摘要翻译： 本发明涉及式（I）的PI3K抑制剂，其中所有变量如说明书中所定义，其制备，其医疗用途，特别是其在治疗癌症和神经变性疾病中的用途，以及 包括它们的药物。
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公开(公告)号：US08008250B2
公开(公告)日：2011-08-30
申请号：US11794412
申请日：2006-01-13
IPC分类号： A61K31/551 , C07D243/00 , C07K7/50
CPC分类号： C07D273/02 , C07D245/06 , C07D291/08 , C07D413/04 , C07D413/12 , C07D419/12
摘要： Macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them are presented.
摘要翻译： R1，R3，V1，V2，X1，X2，Y，Z，Ar，AA和n如本说明书中所定义的下式的大环化合物，大环中包含的环原子数为14,15， 16,17或18，以游离碱形式或酸加成盐形式，其制备，用作药物和包含它们的药物。
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公开(公告)号：US20090029960A1
公开(公告)日：2009-01-29
申请号：US12159742
申请日：2006-12-28
申请人： Claudia Betschart , Manuel Koller , Kurt Laumen , Andreas Lerchner , Rainer Machauer , Clive McCarthy , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Claudia Betschart , Manuel Koller , Kurt Laumen , Andreas Lerchner , Rainer Machauer , Clive McCarthy , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： A61K31/33 , C07D225/00 , A61P25/00
CPC分类号： C07D245/04 , C07D273/00
摘要： The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型大环化合物，其中所有变量如本说明书中所定义，游离碱形式或酸加成盐形式，其制备方法，用作药物和包含它们的药物。
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7.发明申请2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES 审中-公开2,4-二氧-1,4-二氢-2H-喹唑啉-3-基磺酰胺衍生物公开(公告)号：US20130053381A1
公开(公告)日：2013-02-28
申请号：US13638082
申请日：2011-05-18
IPC分类号： C07D403/10 , C07D239/96 , C07D413/14 , A61K31/5377 , C07D405/10 , A61P21/00 , A61P25/28 , A61P25/00 , A61P25/16 , A61P25/18 , A61P1/08 , A61P27/16 , A61K31/517 , A61P25/08
CPC分类号： C07D403/04 , C07D239/96 , C07D405/04
摘要： The invention relates to a 2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl-sulfonamide derivative being (A) a compound of the formula (I) in which the substituents are as defined in the specification; in free form or in salt form; or (B) a compound selected from a certain group of 2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl-sulfonamide derivatives disclosed in the specification; in free form or in salt form; to their preparation, to their use as medicament and to medicaments comprising them. In a first aspect, the invention provides prodrugs of AMPA receptor antagonists which potentially useful in the treatment of a wide range of disorders, particularly epilepsy.
摘要翻译： 本发明涉及2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基 - 磺酰胺衍生物，其为（A）式（I）化合物，其中取代基如说明书中所定义; 以游离形式或盐形式; 或（B）选自本说明书中公开的一组2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基 - 磺酰胺衍生物的化合物; 以游离形式或盐形式; 用于其制备，用作药物和包含它们的药物。 在第一方面，本发明提供AMPA受体拮抗剂的前药，其可用于治疗各种疾病，特别是癫痫。
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公开(公告)号：US08039455B2
公开(公告)日：2011-10-18
申请号：US12159742
申请日：2006-12-28
申请人： Claudia Betschart , Manuel Koller , Kurt Laumen , Andreas Lerchner , Rainer Machauer , Clive McCarthy , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Claudia Betschart , Manuel Koller , Kurt Laumen , Andreas Lerchner , Rainer Machauer , Clive McCarthy , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： C07D245/04 , A61K31/33
CPC分类号： C07D245/04 , C07D273/00
摘要： The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型大环化合物，其中所有变量如本说明书中所定义，游离碱形式或酸加成盐形式，其制备方法，用作药物和包含它们的药物。
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公开(公告)号：US20080214526A1
公开(公告)日：2008-09-04
申请号：US11794412
申请日：2006-01-13
IPC分类号： A61K31/551 , C07D243/00
CPC分类号： C07D273/02 , C07D245/06 , C07D291/08 , C07D413/04 , C07D413/12 , C07D419/12
摘要： The invention relates to novel macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型大环化合物，其中R 1，R 3，V 1，V 2， X，X 1，X 2，Y，Z，Ar，AA和n如说明书中所定义，大环中包括的环原子数为14 ，15,16,17或18，以游离碱形式或以酸加成盐形式，用于制备，用作药物和包含它们的药物。
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公开(公告)号：US20080132477A1
公开(公告)日：2008-06-05
申请号：US11794413
申请日：2006-01-13
申请人： Claudia Betschart , Andreas Lerchner , Rainer Machauer , Heinrich Rueger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Claudia Betschart , Andreas Lerchner , Rainer Machauer , Heinrich Rueger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： A61K31/395 , C07D487/02
CPC分类号： C07D273/00 , C07D245/04 , C07D273/02 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/08
摘要： The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及式（I）的新型大环化合物，其中所有变量如说明书中所定义，大环中包括的环原子数为14,15,16或17，游离碱形式 或以酸加成盐形式，其制备，用作药物和包含它们的药物。
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