公开(公告)号：US12216133B2

公开(公告)日：2025-02-04

申请号：US17218638

申请日：2021-03-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy ,  Yin Cai

IPC: B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C07K14/705 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  G01N35/00 ,  G01N35/10 ,  G06K7/10 ,  G06K7/14 ,  G06K19/06 ,  G06K19/07 ,  G06T7/00 ,  G06T7/90 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

Abstract: A sample handling system for handling samples is disclosed. The sample handling system comprises sample holders, each receives a sample container; a sample transport device for moving the sample holders; a control unit for controlling functionality of the sample handling system, and a monitoring system for monitoring the samples during movement. The monitoring system comprises a camera module for continuously capturing images of a part of the sample transport device, wherein the camera module is at a distance from the sample transport device such that the camera module has a free field of view to the sample transport device, and a processor for processing the captured images and determining an item of information about the sample transport device and/or the sample container and/or the sample from the captured images. The control unit retrieves the item of information from the processor. The controlling is based on the retrieved item of information.

公开(公告)号：US11754431B2

公开(公告)日：2023-09-12

申请号：US17660966

申请日：2022-04-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy

IPC: G01F23/292 ,  G01N15/04 ,  G01N15/05 ,  G01N35/04

CPC classification number: G01F23/2921 ,  G01N15/042 ,  G01N15/05 ,  G01N35/04 ,  G01N2015/045 ,  G01N2035/0493

Abstract: An apparatus for determining a vertical position of at least one interface between a first component and at least one second component, the components comprised as different layers in a sample container. The apparatus comprises a first sensing unit and a first light detector configured to generate a first sensing signal, a second sensing unit comprising a second light detector configured to generate a second sensing signal, a driving unit configured to move the sample container, a position sensing unit configured to output a position sensing signal indicative of a vertical position of the sample container, a vertical position determining unit configured to match the first and the second sensing signal such that first and the second sensing signal correspond to identical vertical positions, and to determine the vertical position of the at least one interface in response to the matched sensing signals and the position sensing signal.

公开(公告)号：US20220373379A1

公开(公告)日：2022-11-24

申请号：US17660966

申请日：2022-04-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy

IPC: G01F23/292 ,  G01N15/04 ,  G01N15/05 ,  G01N35/04

Abstract: An apparatus for determining a vertical position of at least one interface between a first component and at least one second component, the components comprised as different layers in a sample container. The apparatus comprises a first sensing unit and a first light detector configured to generate a first sensing signal, a second sensing unit comprising a second light detector configured to generate a second sensing signal, a driving unit configured to move the sample container, a position sensing unit configured to output a position sensing signal indicative of a vertical position of the sample container, a vertical position determining unit configured to match the first and the second sensing signal such that first and the second sensing signal correspond to identical vertical positions, and to determine the vertical position of the at least one interface in response to the matched sensing signals and the position sensing signal.

公开(公告)号：US20230229541A1

公开(公告)日：2023-07-20

申请号：US18123789

申请日：2023-03-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy ,  André Pristat-Gupta

IPC: G06F11/07

CPC classification number: G06F11/0775 ,  G06F11/079

Abstract: The present disclosure refers to a method for detecting and reporting an operation error in an in-vitro diagnostic system (1) for determining a sample of a bodily fluid, comprising: providing a plurality of sample vessels (2) each containing a sample of a bodily fluid; and providing a plurality of functional modules (3), comprising an analysis device (4) configured to determine the sample, a handling system (5) configured to handle the plurality of sample vessels (2), and an automation track (6) provided by the handling system (5) and configured to transport the plurality of sample vessels (2) to the analysis device (4). The method further comprises: providing an operation control device (7) connected to at least one of the functional modules (3) and configured to control operation of the at least one functional module (3), and comprising one or more data processors (8), wherein an application software is running on the one or more data processors (8) for controlling operation of the at least one functional module (3); controlling operation of the at least one functional module (3) by the operation control device (7); and detecting and reporting an operation error by an error detecting and reporting device (9), comprising: detecting the operating error for the operation of at least one of the plurality of functional modules (3) and the operation control device (7), providing error data indicative of the operation error, receiving a user input through a user interface (10) after detecting the operation error, providing labelling data in response to receiving the user input, the labelling data being indicative of information related to the operating error in addition to the error data, providing error report data comprising the error data and the labelling data, and transmitting the error report data to an error repository (11) remotely located with respect to both the plurality of functional modules (3) and the operation control device (7); receiving the error report data in a machine learning process running in a data processing device connected to the error repository (11); processing the error report data by the machine learning process in the data processing device; providing a application software update for the application software in response to the processing of the error report data by the machine learning process in the data processing device; providing the application software update to the operation control device (7); and controlling operation of the at least one functional module (3) by the operation control device (7) comprising running the application software including the application software update. Further, an in-vitro diagnostic system for determining a sample of a bodily fluid is provided.

公开(公告)号：US20210311083A1

公开(公告)日：2021-10-07

申请号：US17218638

申请日：2021-03-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy ,  Yin Cai

IPC: G01N35/00 ,  G06K7/14 ,  G06K7/10 ,  G06K19/06 ,  G06K19/07

Abstract: A sample handling system for handling samples is disclosed. The sample handling system comprises sample holders, each receives a sample container; a sample transport device for moving the sample holders; a control unit for controlling functionality of the sample handling system, and a monitoring system for monitoring the samples during movement. The monitoring system comprises a camera module for continuously capturing images of a part of the sample transport device, wherein the camera module is at a distance from the sample transport device such that the camera module has a free field of view to the sample transport device, and a processor for processing the captured images and determining an item of information about the sample transport device and/or the sample container and/or the sample from the captured images. The control unit retrieves the item of information from the processor. The controlling is based on the retrieved item of information.