公开(公告)号：US20180136243A1

公开(公告)日：2018-05-17

申请号：US15807802

申请日：2017-11-09

申请人： Roche Diagnostics Operations, Inc.

发明人： Christoph Boehm ,  Sascha Lutz ,  Thomas Keller

IPC分类号： G01N35/00 ,  G01N33/50 ,  B01L3/00

CPC分类号： G01N35/00584 ,  B01L3/5027 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  G01F13/00 ,  G01N33/5005 ,  G01N35/00 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00495

摘要： A method and cartridge for determining an amount of at least two analytes in a biological sample and an automatic analyzer are disclosed. The cartridge may comprise a cartridge inlet, a sample holding chamber fluidically connected to the inlet, and two or more metering chambers. Each metering chamber may comprise a sample inlet, a sample outlet, and a metered outlet for dispensing a predetermined volume. At least one sample distribution channel is connected between the sample outlet of a metering chamber with a sample inlet of another metering chamber. For each metering chamber, a connecting tube fluidically connects the sample inlet with the sample holding chamber, a microfluidic structure for processing the sample into a processed sample connects to the sample outlet, and a measurement structure fluidically connects to the microfluidic structure and enables measurement of the processed sample to determine the amount of the analyte in the processed sample.

公开(公告)号：US10677809B2

公开(公告)日：2020-06-09

申请号：US15807802

申请日：2017-11-09

申请人： Roche Diagnostics Operations, Inc.

发明人： Christoph Boehm ,  Sascha Lutz ,  Thomas Keller

IPC分类号： G01N35/00 ,  G01N33/50 ,  B01L3/00 ,  G01F13/00 ,  G01N35/10

摘要： A method and cartridge for determining an amount of at least two analytes in a biological sample and an automatic analyzer are disclosed. The cartridge may comprise a cartridge inlet, a sample holding chamber fluidically connected to the inlet, and two or more metering chambers. Each metering chamber may comprise a sample inlet, a sample outlet, and a metered outlet for dispensing a predetermined volume. At least one sample distribution channel is connected between the sample outlet of a metering chamber with a sample inlet of another metering chamber. For each metering chamber, a connecting tube fluidically connects the sample inlet with the sample holding chamber, a microfluidic structure for processing the sample into a processed sample connects to the sample outlet, and a measurement structure fluidically connects to the microfluidic structure and enables measurement of the processed sample to determine the amount of the analyte in the processed sample.