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    MEASUREMENT OF AN ANLYTE WITH A CARTRIDGE
    1.
    发明申请
    MEASUREMENT OF AN ANLYTE WITH A CARTRIDGE 有权

    公开(公告)号：US20220280938A1

    公开(公告)日：2022-09-08

    申请号：US17804013

    申请日：2022-05-25

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz

    IPC: B01L3/00 ,  G01N30/74

    Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.

    Rotatable cartridge for processing and analyzing a biological sample and dispensing method therewith
    2.
    发明授权
    Rotatable cartridge for processing and analyzing a biological sample and dispensing method therewith 有权

    公开(公告)号：US11406979B2

    公开(公告)日：2022-08-09

    申请号：US16599673

    申请日：2019-10-11

    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

    Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

    IPC: B01L3/00 ,  G01N1/38 ,  G01N35/00 ,  G01N35/10

    Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.

    Rotatable cartridge with multiple metering chambers
    3.
    发明授权
    Rotatable cartridge with multiple metering chambers 有权

    公开(公告)号：US10677809B2

    公开(公告)日：2020-06-09

    申请号：US15807802

    申请日：2017-11-09

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Boehm ,  Sascha Lutz ,  Thomas Keller

    IPC: G01N35/00 ,  G01N33/50 ,  B01L3/00 ,  G01F13/00 ,  G01N35/10

    Abstract: A method and cartridge for determining an amount of at least two analytes in a biological sample and an automatic analyzer are disclosed. The cartridge may comprise a cartridge inlet, a sample holding chamber fluidically connected to the inlet, and two or more metering chambers. Each metering chamber may comprise a sample inlet, a sample outlet, and a metered outlet for dispensing a predetermined volume. At least one sample distribution channel is connected between the sample outlet of a metering chamber with a sample inlet of another metering chamber. For each metering chamber, a connecting tube fluidically connects the sample inlet with the sample holding chamber, a microfluidic structure for processing the sample into a processed sample connects to the sample outlet, and a measurement structure fluidically connects to the microfluidic structure and enables measurement of the processed sample to determine the amount of the analyte in the processed sample.

    Rotatable cartridge for processing and analyzing a biological sample
    4.
    发明授权
    Rotatable cartridge for processing and analyzing a biological sample 有权

    公开(公告)号：US10478817B2

    公开(公告)日：2019-11-19

    申请号：US15943093

    申请日：2018-04-02

    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

    Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

    IPC: B01L3/00 ,  G01N1/38 ,  G01N35/00 ,  G01N35/10

    Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.

    Cartridge with a rotatable lid
    5.
    发明授权
    Cartridge with a rotatable lid 有权

    公开(公告)号：US10086373B2

    公开(公告)日：2018-10-02

    申请号：US15352698

    申请日：2016-11-16

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke ,  Thorsten Brueckner

    IPC: B01L3/00 ,  G01N35/00 ,  G01N21/07 ,  G01N21/64 ,  G01N21/03

    Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has a support structure with a front face perpendicular to the rotational axis, a fluidic structure for processing a biological sample into the processed biological sample, a measurement structure with at least one detection zone on the front face, and a rotatable lid covering the front face. The rotatable lid is rotatable about the rotational axis relative to the support structure from a first position relative to the support structure to a second position relative to the support structure. The rotatable lid has a sample inlet opening and a detection zone opening. In the first position, a sample inlet is aligned with the sample inlet opening and the measurement structure is covered by the rotatable lid. In the second position, the sample inlet is covered by the rotatable lid and the measurement structure is aligned with the detection zone opening.

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