公开(公告)号：US11078534B2

公开(公告)日：2021-08-03

申请号：US16199757

申请日：2018-11-26

Applicant: Roche Molecular Systems, Inc.

Inventor： Alexander Nierth ,  Hannes Kuchelmeister ,  Concordio Anacleto ,  Amar Gupta ,  Dieter Heindl ,  Igor Kozlov ,  Christian Wellner ,  Stephen Gordon Will

IPC: C12Q1/68 ,  C07H19/10 ,  C07H19/20 ,  C07H21/02 ,  C12Q1/6876 ,  C12Q1/6848 ,  C12Q1/686

Abstract: The present invention provides for stable nucleotide reagents used for nucleic acid amplification by PCR and RT-PCR (Reverse Transcriptase-PCR) that comprises modified nucleoside triphosphates. The present invention also provides for methods for using the modified nucleoside triphosphates for detecting the presence or absence of a target nucleic acid sequence in a sample in an amplification reaction.

公开(公告)号：US20190161797A1

公开(公告)日：2019-05-30

申请号：US16199757

申请日：2018-11-26

Applicant: Roche Molecular Systems, Inc.

Inventor： Alexander Nierth ,  Hannes Kuchelmeister ,  Concordio Anacleto ,  Amar Gupta ,  Dieter Heindl ,  Igor Kozlov ,  Christian Wellner ,  Stephen Gordon Will

IPC: C12Q1/6876 ,  C07H21/02

Abstract: The present invention provides for stable nucleotide reagents used for nucleic acid amplification by PCR and RT-PCR (Reverse Transcriptase-PCR) that comprises modified nucleoside triphosphates. The present invention also provides for methods for using the modified nucleoside triphosphates for detecting the presence or absence of a target nucleic acid sequence in a sample in an amplification reaction.

公开(公告)号：US11739378B2

公开(公告)日：2023-08-29

申请号：US17201834

申请日：2021-03-15

Applicant: Roche Molecular Systems, Inc. ,  Roche Sequencing Solutions, Inc.

Inventor： Frank Bergmann ,  Christoph Seidel ,  Andrew Trans ,  Dmitriy Gremyachinskiy ,  Hannes Kuchelmeister ,  Lars Hillringhaus

IPC: C12Q1/68 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869

CPC classification number: C12Q1/6869 ,  C07H19/10 ,  C07H19/20 ,  C12Q2525/113 ,  C12Q2525/197 ,  C12Q2525/203 ,  C12Q2525/204 ,  C12Q2565/631 ,  C12Q1/6869 ,  C12Q2525/113 ,  C12Q2525/197 ,  C12Q2525/203 ,  C12Q2525/204 ,  C12Q2565/631

Abstract: The present disclosure relates to compositions and methods based on polypeptide-tagged nucleotide, and the use of such polypeptide-tagged nucleotides in nanopore devices and methods.

公开(公告)号：US10975426B2

公开(公告)日：2021-04-13

申请号：US15770922

申请日：2016-08-26

Applicant: Roche Molecular Systems, Inc. ,  Roche Sequencing Solutions, Inc.

Inventor： Frank Bergmann ,  Christoph Seidel ,  Andrew Trans ,  Dmitriy Gremyachinskiy ,  Hannes Kuchelmeister ,  Lars Hillringhaus

IPC: C12Q1/68 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869

Abstract: The present disclosure relates to compositions and methods based on polypeptide-tagged nucleotide, and the use of such polypeptide-tagged nucleotides in nanopore devices and methods.