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公开(公告)号：US08211656B2
公开(公告)日：2012-07-03
申请号：US12228880
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号： G01N33/555 , A61K31/00
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
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公开(公告)号：US20100042072A1
公开(公告)日：2010-02-18
申请号：US12228893
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61K35/18 , A61K41/0071 , A61K47/6901 , A61K49/0002 , A61K49/0097 , C12N5/0006 , C12N5/0641 , Y02A50/411 , Y02A50/463 , Y02A50/465 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
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公开(公告)号：US20120134975A1
公开(公告)日：2012-05-31
申请号：US12228869
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61K35/18 , A61P31/00 , C12N5/10 , A61P31/10 , A61P33/00 , C12N5/078 , A61P35/00 , A61P31/12
CPC分类号： A61K41/0071 , A61K35/18 , A61K47/6803 , A61K47/6898 , A61K2035/124 , B82Y5/00
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
摘要翻译： 描述了改良的红细胞。 在一个实施方案中，修饰的红细胞包括靶结合剂。 描述了使用修饰的红细胞靶向递送成像剂，药物和肽和蛋白质药物。 描述了制备改性红细胞的方法，含有其的药物和诊断组合物以及涉及修饰的红细胞的诊断和治疗方法。
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公开(公告)号：US20100041133A1
公开(公告)日：2010-02-18
申请号：US12228868
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： C12N5/06
CPC分类号： A61K41/0071 , A61K47/6901 , A61K49/0002
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
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公开(公告)号：US20100041014A1
公开(公告)日：2010-02-18
申请号：US12228880
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： G01N33/555 , A61K31/00
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
摘要翻译： 描述了改良的红细胞。 在一个实施方案中，修饰的红细胞包括靶结合剂。 描述了使用修饰的红细胞靶向递送成像剂，药物和肽和蛋白质药物。 描述了制备改性红细胞的方法，含有其的药物和诊断组合物以及涉及修饰的红细胞的诊断和治疗方法。
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公开(公告)号：US20100040546A1
公开(公告)日：2010-02-18
申请号：US12228892
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61K41/0028 , A61K41/0071 , A61K47/6901 , A61K49/0002 , A61K49/0097 , A61K49/0409 , G01N33/542 , G01N33/586 , G01N2458/30 , Y02A50/52 , Y02A50/58
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
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公开(公告)号：US08041005B2
公开(公告)日：2011-10-18
申请号：US11906161
申请日：2007-09-28
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Robert W. Lord , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L Wood, Jr. , Victoria Y. H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Robert W. Lord , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L Wood, Jr. , Victoria Y. H. Wood
IPC分类号： G01N23/223
CPC分类号： G01N23/223 , G01N2223/076
摘要： One aspect relates to inducing at least one induced X-ray fluorescing photon within an at least some matter of an at least a portion of an at least one individual responsive to a substantial single input energy event based at least partially on an at least some input energy being applied to the at least some matter of the at least the portion of the at least one individual; and detecting the at least one induced X-ray fluorescing photon; and X-ray fluorescence visualizing, imaging, or information providing within the at least some matter of the at least the portion of the at least one individual responsive to the detecting the at least one induced X-ray fluorescing photon.
摘要翻译： 一个方面涉及至少部分地基于至少一些输入而在至少一个个体的至少一部分的至少一些物质内诱导至少一个诱导的X射线荧光光子，所述至少一个个体响应于基本的单个输入能量事件 能量被施加到至少一个个体的至少一部分的至少一些物质; 以及检测所述至少一个诱导的X射线荧光光子; 以及响应于检测所述至少一个诱导的X射线荧光光子，在所述至少一个个体的至少一部分的至少一些物质内提供X射线荧光可视化，成像或信息。
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8.发明授权Proximity-based X-Ray fluorescence visualizer, imager, or information provider 有权基于接近度的X射线荧光显像仪，成像仪或信息提供者公开(公告)号：US07724867B2
公开(公告)日：2010-05-25
申请号：US11906135
申请日：2007-09-28
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Robert W. Lord , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Robert W. Lord , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： G01N23/223
CPC分类号： A61B6/503 , A61B5/415 , A61B5/418 , A61B5/489 , A61B6/12 , A61B6/14 , A61B6/4021 , A61B6/4291 , A61B6/482 , A61B6/485 , A61B6/50 , A61B6/501 , A61B6/502 , A61B6/504 , A61B6/505 , A61B6/506 , A61B6/507 , A61B6/508 , A61B2503/40 , G01N23/223 , G01N2223/076
摘要： One aspect relates to detecting at least one induced X-ray fluorescing photon fluoresced from substantially within an at least some matter of an at least a portion of an at least one individual at least partially as a result of receiving at least one induced X-ray fluorescing photon generated at least partially within at least one X-ray fluorescence event within the at least some matter of the at least the portion of the at least one individual which has been generated responsive to an at least some input energy resulting from a single input energy event, wherein the at least one induced X-ray fluorescing photon that has passed through the at least some matter of the at least the portion of the at least one individual is at a level to substantially limit interference between the at least one induced X-ray fluorescing photon with an at least one other induced X-ray fluorescing photon that travel for distances greater than a prescribed limit through the at least some matter of the at least the portion of the at least one individual, wherein the at least one other induced X-ray fluorescing photon attenuates by a prescribed percentage after passing through the prescribed distance through the at least some matter of the at least the portion of the at least one individual.
摘要翻译： 一个方面涉及至少部分地检测至少一个感兴趣的X射线荧光光子，其基本上在至少一个个体的至少一部分的至少一些物质内发射，作为接收至少一个诱导X射线 至少部分地在至少一个X射线荧光事件中产生荧光光子，所述至少一个X射线荧光事件在所述至少一个个体的至少一部分中的至少一些物质中响应于由单个输入产生的至少一些输入能量而产生 能量事件，其中已经通过所述至少一个个体的至少一部分的至少一些物质的所述至少一个感兴趣的X射线荧光光子处于基本上限制所述至少一个诱导X 具有至少一个其它诱导的X射线荧光光子的荧光光子，其行进距离大于规定的极限，通过至少一些事件 所述至少一个个体的部分，其中所述至少一个其它诱导的X射线荧光光子在经过所述规定距离之后通过所述至少一个的所述至少一部分的所述至少一些物质衰减预定百分比 个人。
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9.发明授权Scintillator aspects of compton scattered X-ray visualization, imaging, or information providing 有权康普顿散射X射线可视化，成像或信息提供的闪烁体方面公开(公告)号：US07711089B2
公开(公告)日：2010-05-04
申请号：US11786776
申请日：2007-04-11
申请人： Edward S. Boyden , Glenn B. Foster , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Robert W. Lord , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Edward S. Boyden , Glenn B. Foster , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Robert W. Lord , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： G01N23/201
CPC分类号： G01N23/201
摘要： A visualization or imaging system involves inducing and/or detecting Compton scattered X-rays to provide information or a visual representation of a portion of an individual. In one approach, the Compton scattered X-rays are converted to a visible or detectible representations through scintillation.
摘要翻译： 可视化或成像系统包括诱导和/或检测康普顿散射的X射线以提供个体的一部分的信息或视觉表示。 在一种方法中，康普顿散射的X射线通过闪烁转换为可见或可检测的表示。
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10.发明授权X-ray fluorescence visualizing, imaging, or information providing of chemicals, compounds, or biological materials 有权化学，化合物或生物材料的X射线荧光可视化，成像或信息提供公开(公告)号：US07664224B2
公开(公告)日：2010-02-16
申请号：US12002287
申请日：2007-12-14
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Robert W. Lord , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Robert W. Lord , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： G01N23/223
CPC分类号： G01N23/223 , G01N2223/076
摘要： One aspect can relate to detecting a presence of an at least one chemical, compound, or biological material contained in an at least some matter of an at least a portion of an at least one individual based at least partially on addition of an at least one chemical identifying additive to the at least some matter of the at least the portion of the at least one individual based at least partially on a generation of an at least one induced X-ray fluorescing photon within the at least one chemical identifying additive responsive to a single input energy event in which an at least some input energy is being applied proximal to the at least one chemical, compound, or biological material contained in the at least some matter of the at least the portion of the at least one individual.
摘要翻译： 一个方面可以涉及至少部分地基于添加至少一个个体的至少一个个体的至少一部分的至少一些物质中的至少一种化学，化合物或生物材料的存在来检测 至少部分地至少部分地基于在所述至少一种化学鉴定添加剂中产生至少一种诱导的X射线荧光光子的化学鉴定添加剂至少部分至少一部分物质的化学鉴定添加剂，其响应于 单输入能量事件，其中至少一些输入能量被施加在至少一个化学，化合物或生物材料的近端，该至少一种化学，化合物或生物材料包含在至少一个个体的至少一部分的该至少一些物质中。
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