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22 条记录 (耗时 0.028 秒)

    Small molecule composite surfaces as inhibitors of protein-protein interactions
    2.
    发明授权
    Small molecule composite surfaces as inhibitors of protein-protein interactions 有权
    小分子复合物表面作为蛋白质 - 蛋白质相互作用的抑制剂

    公开(公告)号：US09260484B2

    公开(公告)日：2016-02-16

    申请号：US14126343

    申请日：2012-06-15

    申请人： Roger Briesewitz ,  Dehua Pei ,  Xianghong Wu

    发明人： Roger Briesewitz ,  Dehua Pei ,  Xianghong Wu

    IPC分类号： A61K38/00 ,  A61K38/12 ,  C07K11/02

    CPC分类号： C07K11/02 ,  A61K38/00 ,  A61K38/12

    摘要： A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    摘要翻译： 一种抑制靶蛋白和结合蛋白之间的结合事件的方法，包括向细胞体外施用有效量的非天然存在的双功能抑制剂分子，包括（a）蛋白质结合部分，和（b）效应子区域 其中所述蛋白质结合部分与阻断蛋白结合，并且其中所述效应区结合所述靶蛋白以便结合所述靶蛋白和所述阻断蛋白并阻止所述结合蛋白进入所述靶蛋白。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

    SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS
    3.
    发明申请
    SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS 有权
    作为蛋白质 - 蛋白质相互作用的抑制剂的小分子复合表面

    公开(公告)号：US20140200186A1

    公开(公告)日：2014-07-17

    申请号：US14126343

    申请日：2012-06-15

    申请人： Roger Briesewitz ,  Dehua Pei ,  Xianghong Wu

    发明人： Roger Briesewitz ,  Dehua Pei ,  Xianghong Wu

    IPC分类号： C07K11/02

    CPC分类号： C07K11/02 ,  A61K38/00 ,  A61K38/12

    摘要： A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    摘要翻译： 一种抑制靶蛋白和结合蛋白之间的结合事件的方法，包括向细胞体外施用有效量的非天然存在的双功能抑制剂分子，包括（a）蛋白质结合部分，和（b）效应子区域 其中所述蛋白质结合部分与阻断蛋白结合，并且其中所述效应区结合所述靶蛋白以便结合所述靶蛋白和所述阻断蛋白并阻止所述结合蛋白进入所述靶蛋白。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

    SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS
    4.
    发明申请
    SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS 审中-公开
    作为蛋白质 - 蛋白质相互作用的抑制剂的小分子复合表面

    公开(公告)号：US20160333054A1

    公开(公告)日：2016-11-17

    申请号：US14997302

    申请日：2016-08-01

    申请人： Roger Briesewitz ,  Dehua Pei ,  Xianghong Wu

    发明人： Roger Briesewitz ,  Dehua Pei ,  Xianghong Wu

    IPC分类号： C07K11/02

    CPC分类号： C07K11/02 ,  A61K38/00 ,  A61K38/12

    摘要： A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    摘要翻译： 一种抑制靶蛋白和结合蛋白之间的结合事件的方法，包括向细胞体外施用有效量的非天然存在的双功能抑制剂分子，包括（a）蛋白质结合部分，和（b）效应子区域 其中所述蛋白质结合部分与阻断蛋白结合，并且其中所述效应区结合所述靶蛋白以便结合所述靶蛋白和所述阻断蛋白并阻止所述结合蛋白进入所述靶蛋白。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

    Peptidyl inhibitors of calcineurin-NFAT interaction
    9.
    发明授权
    Peptidyl inhibitors of calcineurin-NFAT interaction 有权

    公开(公告)号：US11576946B2

    公开(公告)日：2023-02-14

    申请号：US16965718

    申请日：2019-01-29

    申请人： Ohio State Innovation Foundation

    发明人： Dehua Pei ,  John W. Christman ,  Manjula Karpurapu ,  Patrick G. Dougherty

    IPC分类号： A61K38/08 ,  A61K47/64 ,  A61P11/00

    摘要： Described are peptides and peptide conjugates comprising CN binding motifs (CNBM) which inhibit the CN-NFAT interaction. In some embodiments, the peptides comprise: (i) CNBM; (ii) a hydrophobic, non-peptidic moiety (RH) which interacts with the hydrophobic pocket on a CN protein; (iii) a sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-, wherein each of AAU2, AAU3, AAU4, AAU5, and AAU6, is, independently, optional, and each of AAU1, AAU2, AAU3, AAU4, AAU5, and AAU6 when present is independently an amino acid as defined herein; or (iv) combinations thereof. In some embodiments, RH is conjugated to the N- or C-terminus of the CNBM. In some embodiments, the sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6- is conjugated to the N- or C terminus of the CNBM. In some embodiments, the peptides comprise: CNBM and RH. In some embodiments. In some embodiments, the peptides comprise: CNBM and AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-. In some embodiments, the peptides of the disclosure CNBM and RH.