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公开(公告)号:US20050233361A1
公开(公告)日:2005-10-20
申请号:US11093816
申请日:2005-03-30
申请人: Roger Clerc , Martin Ebeling , Christophe Gardes , Markus Meyer , Matthew Wright
发明人: Roger Clerc , Martin Ebeling , Christophe Gardes , Markus Meyer , Matthew Wright
IPC分类号: G01N33/50 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/10 , A61P29/00 , A61P43/00 , C07K14/47 , C12N15/09 , C12N15/63 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/566 , G01N33/68
CPC分类号: C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要: The present invention relates to ANGPTL4 as biomarkers for PPARdelta activity, and to methods of diagnosing a disease linked to dysregulation of PPARdelta activity such as for example dyslipidemia, obesity or insulin resistance, methods of monitoring the treatment of patients suffering from a disease linked to dysregulation of PPARdelta activity and methods of identifying compounds which modulate PPARdelta activity.
摘要翻译: 本发明涉及ANGPTL4作为PPARδ活性的生物标志物,以及诊断与PPARδ活性异常调节有关的疾病的方法,例如血脂异常,肥胖或胰岛素抵抗,监测患有与失调相关的疾病的患者的治疗方法 的PPARdta活性和鉴定调节PPARδ活性的化合物的方法。
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公开(公告)号:US20050136465A1
公开(公告)日:2005-06-23
申请号:US11019829
申请日:2004-12-22
申请人: Roger Clerc , Guillemette Duchateau-Nguyen , Christophe Gardes , Jacques Mizrahi , Claes-Goran Ostenson
发明人: Roger Clerc , Guillemette Duchateau-Nguyen , Christophe Gardes , Jacques Mizrahi , Claes-Goran Ostenson
IPC分类号: G01N33/50 , A61K45/00 , A61P3/04 , A61P35/00 , C12N15/09 , C12Q1/02 , C12Q1/25 , C12Q1/26 , C12Q1/32 , C12Q1/37 , C12Q1/48 , C12Q1/50 , C12Q1/527 , C12Q1/533 , C12Q1/68 , G01N33/15 , G01N33/68
CPC分类号: G01N33/5005 , G01N33/5008 , G01N33/5023 , G01N33/68 , G01N2500/00
摘要: The present invention relates to novel targets for identifying compounds that may be useful for the prevention and treatment of obesity.
摘要翻译: 本发明涉及用于鉴定可用于预防和治疗肥胖症的化合物的新靶标。
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公开(公告)号:US20050158771A1
公开(公告)日:2005-07-21
申请号:US11019855
申请日:2004-12-22
申请人: Roger Clerc , Guillemette Duchateau-Nguyen , Christophe Gardes , Jacques Mizrahi , Claes-Goran Ostenson
发明人: Roger Clerc , Guillemette Duchateau-Nguyen , Christophe Gardes , Jacques Mizrahi , Claes-Goran Ostenson
IPC分类号: G01N33/50 , A61K38/00 , A61K45/00 , A61P3/04 , A61P7/00 , A61P43/00 , C07K14/47 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , C12N15/85
CPC分类号: C12Q1/6827 , C12Q1/6883
摘要: The present invention relates to novel gene and polypeptide targets identified in skeletal muscle for screening of compounds that may be useful for the prevention and treatment of obesity.
摘要翻译: 本发明涉及用于筛选可用于预防和治疗肥胖症的化合物的骨骼肌中鉴定的新基因和多肽靶标。
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