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公开(公告)号：US06855293B1
公开(公告)日：2005-02-15
申请号：US09936881
申请日：2000-03-22
IPC分类号： G01N33/53 , B01J4/00 , B01J19/00 , B01L3/02 , C40B60/14 , F04B19/00 , G01N1/00 , G01N1/28 , G01N33/48 , G01N33/566 , G01N35/10 , G01N37/00 , B01L3/00 , B01L9/00 , B01L11/00 , G01N15/06
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , C40B60/14 , F04B19/006 , G01N35/1067 , G01N2035/1041 , G01N2035/1069 , Y10T436/2575
摘要： A fluid management apparatus includes a substrate having a first surface and a second surface opposite to the first surface. A plurality of fluid inlets, which are preferably media reservoirs, are formed in a first pattern in the first surface of the substrate. A plurality of fluid outlets, which are preferably nozzles, are arranged in a second pattern, which is different from the first pattern, in the second surface of the substrate. A plurality of fluid ducts formed in the substrate for connecting respective fluid inlets with respective fluid outlets are provided so that a format conversation from the fluid inlets to the fluid outlets is effected. The fluid outlets have opening cross-sections smaller than that of the fluid inlets. Furthermore, the fluid inlets may be arranged in the raster scheme of microtiter plates.
摘要翻译： 流体管理装置包括具有第一表面和与第一表面相对的第二表面的基底。 在衬底的第一表面中以第一图案形成多个流体入口，其优选地是介质储存器。 优选地，喷嘴的多个流体出口在基板的第二表面中以与第一图案不同的第二图案布置。 形成在衬底中的多个流体管道，用于将相应的流体入口与相应的流体出口连接，从而实现从流体入口到流体出口的格式对话。 流体出口具有小于流体入口的开口横截面。 此外，流体入口可以以微量滴定板的光栅方案排列。
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公开(公告)号：US06416294B1
公开(公告)日：2002-07-09
申请号：US09582917
申请日：2000-08-07
IPC分类号： F09B1700
CPC分类号： G01N35/1016 , B01J2219/00351 , B01J2219/00378 , B01L3/0203 , B01L3/0268 , B01L2400/0481 , C40B60/14 , F04B43/046 , G01F11/08 , G01N2035/00237
摘要： A volume sensor-free microdosing device comprises a pressure chamber which is at least partly delimited by a displacer, an actuating device for actuating the displacer, the volume of the pressure chamber being adapted to the changed by actuating the displacer, a media reservoir which is in fluid communication with the pressure chamber, an outlet opening which is in fluid communication with the pressure chamber, and a control mechanism. The control mechanism drives the microdosing device in such a way that a small change of volume of the pressure chamber volume is effected per unit time by a movement of the displacer from a first position to a predetermined second position, the second position of the displacer defining a larger volume of the pressure chamber than the first position, so as to suck a fluid volume into the pressure chamber, and that, in a second phase, a large volume change of the pressure chamber volume is effected per unit time by a movement of the displacer from the second position to the first position, so as to eject a defined fluid volume from the outlet opening in this way.
摘要翻译： 无体积传感器的微量计量装置包括至少部分地由置换器限定的压力室，用于致动置换器的致动装置，压力室的体积适于通过致动置换器而改变;介质储存器， 与压力室流体连通，与压力室流体连通的出口和控制机构。 控制机构以这样一种方式驱动微量计量装置，使得通过置换器从第一位置到预定的第二位置的运动，每单位时间实现压力室体积的小的变化，位移器的第二位置限定 比第一位置更大的压力室体积，以便将流体体积吸入压力室，并且在第二阶段中，通过运动使单位时间内每单位时间内容积变化的压力室体积 所述置换器从所述第二位置到所述第一位置，以便以这种方式从所述出口开口排出限定的流体体积。
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公开(公告)号：US06399395B1
公开(公告)日：2002-06-04
申请号：US09416129
申请日：1999-10-12
IPC分类号： C12M136
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , C40B60/14 , F04B19/006 , G01N35/1067 , G01N2035/1041 , G01N2035/1069 , Y10T436/2575
摘要： A device for applying microdroplets to a substrate includes a dosing head having a nozzle orifice and a liquid storage area in fluid communication with the orifice. A drive applies an acceleration to the dosing head. A quantity of liquid in the storage area cannot follow the acceleration due to its inertia. This inertia causes microdroplets to be driven out of the nozzle onto the substrate. In one embodiment, the dosing head includes a plurality of nozzle orifices each having an associated liquid storage area, so that a plurality of different analytes are deposited on the substrate.
摘要翻译： 用于将微滴施加到基底的装置包括具有喷嘴孔口和与孔口流体连通的液体储存区域的计量头。 驱动器对加药头施加加速度。 存储区域中的液体量由于其惯性而不能跟随加速度。 该惯性导致微滴从喷嘴驱动到基板上。 在一个实施例中，计量头包括多个具有相关联的液体储存区域的喷嘴孔，使得多个不同的分析物沉积在基底上。
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4.发明授权公开(公告)号：US07479256B1
公开(公告)日：2009-01-20
申请号：US10069852
申请日：2000-04-10
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , B01L2400/0481 , C40B60/14 , G01N2035/1041
摘要： A device for device for applying a plurality of microdroplets onto a substrate has a plurality of nozzle orifices in a dosing head. In addition to walls for defining a liquid column of a medium to be dosed on each nozzle orifice, a pressure chamber is provided, which is adapted to be filled with a buffer medium and which is arranged in such a way that said buffer medium can simultaneously be used for applying a pressure to the liquid-column ends which are spaced apart from the nozzle orifices. A pressure generator is provided for applying a pressure to said buffer medium in such a way that a plurality of microdroplets will simultaneously be applied onto the substrate through said plurality of nozzle orifices. Finally, liquid reservoirs for the media to be dosed, which are in fluid communication with the liquid columns on the nozzle orifices are provided.
摘要翻译： 用于将多个微滴施加到基底上的装置的装置在计量头中具有多个喷嘴孔。 除了用于限定要在每个喷嘴孔口上定量的介质的液柱的壁之外，还提供了压力室，其适于填充有缓冲介质，并且其布置成使得所述缓冲介质可以同时 用于对与喷嘴孔间隔开的液柱端施加压力。 提供压力发生器，用于向所述缓冲介质施加压力，使得多个微滴同时通过所述多个喷嘴孔施加到基板上。 最后，提供了用于与喷嘴孔上的液体柱流体连通的介质的液体储存器。
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