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公开(公告)号：US06855293B1
公开(公告)日：2005-02-15
申请号：US09936881
申请日：2000-03-22
IPC分类号： G01N33/53 , B01J4/00 , B01J19/00 , B01L3/02 , C40B60/14 , F04B19/00 , G01N1/00 , G01N1/28 , G01N33/48 , G01N33/566 , G01N35/10 , G01N37/00 , B01L3/00 , B01L9/00 , B01L11/00 , G01N15/06
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , C40B60/14 , F04B19/006 , G01N35/1067 , G01N2035/1041 , G01N2035/1069 , Y10T436/2575
摘要： A fluid management apparatus includes a substrate having a first surface and a second surface opposite to the first surface. A plurality of fluid inlets, which are preferably media reservoirs, are formed in a first pattern in the first surface of the substrate. A plurality of fluid outlets, which are preferably nozzles, are arranged in a second pattern, which is different from the first pattern, in the second surface of the substrate. A plurality of fluid ducts formed in the substrate for connecting respective fluid inlets with respective fluid outlets are provided so that a format conversation from the fluid inlets to the fluid outlets is effected. The fluid outlets have opening cross-sections smaller than that of the fluid inlets. Furthermore, the fluid inlets may be arranged in the raster scheme of microtiter plates.
摘要翻译： 流体管理装置包括具有第一表面和与第一表面相对的第二表面的基底。 在衬底的第一表面中以第一图案形成多个流体入口，其优选地是介质储存器。 优选地，喷嘴的多个流体出口在基板的第二表面中以与第一图案不同的第二图案布置。 形成在衬底中的多个流体管道，用于将相应的流体入口与相应的流体出口连接，从而实现从流体入口到流体出口的格式对话。 流体出口具有小于流体入口的开口横截面。 此外，流体入口可以以微量滴定板的光栅方案排列。
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公开(公告)号：US06416294B1
公开(公告)日：2002-07-09
申请号：US09582917
申请日：2000-08-07
IPC分类号： F09B1700
CPC分类号： G01N35/1016 , B01J2219/00351 , B01J2219/00378 , B01L3/0203 , B01L3/0268 , B01L2400/0481 , C40B60/14 , F04B43/046 , G01F11/08 , G01N2035/00237
摘要： A volume sensor-free microdosing device comprises a pressure chamber which is at least partly delimited by a displacer, an actuating device for actuating the displacer, the volume of the pressure chamber being adapted to the changed by actuating the displacer, a media reservoir which is in fluid communication with the pressure chamber, an outlet opening which is in fluid communication with the pressure chamber, and a control mechanism. The control mechanism drives the microdosing device in such a way that a small change of volume of the pressure chamber volume is effected per unit time by a movement of the displacer from a first position to a predetermined second position, the second position of the displacer defining a larger volume of the pressure chamber than the first position, so as to suck a fluid volume into the pressure chamber, and that, in a second phase, a large volume change of the pressure chamber volume is effected per unit time by a movement of the displacer from the second position to the first position, so as to eject a defined fluid volume from the outlet opening in this way.
摘要翻译： 无体积传感器的微量计量装置包括至少部分地由置换器限定的压力室，用于致动置换器的致动装置，压力室的体积适于通过致动置换器而改变;介质储存器， 与压力室流体连通，与压力室流体连通的出口和控制机构。 控制机构以这样一种方式驱动微量计量装置，使得通过置换器从第一位置到预定的第二位置的运动，每单位时间实现压力室体积的小的变化，位移器的第二位置限定 比第一位置更大的压力室体积，以便将流体体积吸入压力室，并且在第二阶段中，通过运动使单位时间内每单位时间内容积变化的压力室体积 所述置换器从所述第二位置到所述第一位置，以便以这种方式从所述出口开口排出限定的流体体积。
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公开(公告)号：US06399395B1
公开(公告)日：2002-06-04
申请号：US09416129
申请日：1999-10-12
IPC分类号： C12M136
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , C40B60/14 , F04B19/006 , G01N35/1067 , G01N2035/1041 , G01N2035/1069 , Y10T436/2575
摘要： A device for applying microdroplets to a substrate includes a dosing head having a nozzle orifice and a liquid storage area in fluid communication with the orifice. A drive applies an acceleration to the dosing head. A quantity of liquid in the storage area cannot follow the acceleration due to its inertia. This inertia causes microdroplets to be driven out of the nozzle onto the substrate. In one embodiment, the dosing head includes a plurality of nozzle orifices each having an associated liquid storage area, so that a plurality of different analytes are deposited on the substrate.
摘要翻译： 用于将微滴施加到基底的装置包括具有喷嘴孔口和与孔口流体连通的液体储存区域的计量头。 驱动器对加药头施加加速度。 存储区域中的液体量由于其惯性而不能跟随加速度。 该惯性导致微滴从喷嘴驱动到基板上。 在一个实施例中，计量头包括多个具有相关联的液体储存区域的喷嘴孔，使得多个不同的分析物沉积在基底上。
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4.发明授权公开(公告)号：US07479256B1
公开(公告)日：2009-01-20
申请号：US10069852
申请日：2000-04-10
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , B01L2400/0481 , C40B60/14 , G01N2035/1041
摘要： A device for device for applying a plurality of microdroplets onto a substrate has a plurality of nozzle orifices in a dosing head. In addition to walls for defining a liquid column of a medium to be dosed on each nozzle orifice, a pressure chamber is provided, which is adapted to be filled with a buffer medium and which is arranged in such a way that said buffer medium can simultaneously be used for applying a pressure to the liquid-column ends which are spaced apart from the nozzle orifices. A pressure generator is provided for applying a pressure to said buffer medium in such a way that a plurality of microdroplets will simultaneously be applied onto the substrate through said plurality of nozzle orifices. Finally, liquid reservoirs for the media to be dosed, which are in fluid communication with the liquid columns on the nozzle orifices are provided.
摘要翻译： 用于将多个微滴施加到基底上的装置的装置在计量头中具有多个喷嘴孔。 除了用于限定要在每个喷嘴孔口上定量的介质的液柱的壁之外，还提供了压力室，其适于填充有缓冲介质，并且其布置成使得所述缓冲介质可以同时 用于对与喷嘴孔间隔开的液柱端施加压力。 提供压力发生器，用于向所述缓冲介质施加压力，使得多个微滴同时通过所述多个喷嘴孔施加到基板上。 最后，提供了用于与喷嘴孔上的液体柱流体连通的介质的液体储存器。
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公开(公告)号：US06280148B1
公开(公告)日：2001-08-28
申请号：US09367664
申请日：1999-08-17
申请人： Roland Zengerle , Michael Freygang , Manfred Stehr , Stephan Messner , Matthias Ashauer , Rainer Rossberg
发明人： Roland Zengerle , Michael Freygang , Manfred Stehr , Stephan Messner , Matthias Ashauer , Rainer Rossberg
IPC分类号： F04B4906
CPC分类号： H01L41/00 , B01J2219/00351 , B01J2219/00364 , B01J2219/00378 , B01L3/0265 , B01L3/0268 , B01L3/5027 , B01L2200/146 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0439 , B01L2400/0487 , B05B9/0413 , C40B60/14 , F04B19/006 , F04B43/046 , F04B2201/0201 , G01F11/08 , G01N35/00 , G01N2035/00237
摘要： A microdosing device comprises a pressure chamber which is at least partly delimited by a displacer, an actuating device for actuating the displacer, the volume of the pressure chamber being adapted to be changed by actuating the displacer, a media reservoir which is in fluid comunication with the pressure chamber via a first fluid line, and an outlet opening which is in fluid communication with the pressure chamber via a second fluid line. The microdosing device additionally comprises a means for detecting the respective position of the displacer and a control means which is connected to the actuating device and to the means for detecting the position of the displacer, said control means controlling the actuating device on the basis of the detected position of the displacer or on the basis of displacer positions detected during at least one preceding dosing cycle so as to cause the discharge of a defined volume of fluid from the outlet opening. The control means comprises means for controlling the actuating device with a signal of low edge steepness so as to cause the displacer to move from a first position to a predetermined second position, the second position of the displacer defining a larger volume of the pressure chamber than the first position. In addition, the control means comprises means for controlling the actuating device with a signal of high edge steepness so as to cause the displacer to move from the second position to the first position for discharging in this way a defined volume of fluid from the outlet opening.
摘要翻译： 微量饮料装置包括至少部分地由置换器限定的压力室，用于致动置换器的致动装置，压力室的体积适于通过致动置换器来改变;压力室的体积可以通过流体通过与 经由第一流体管线的压力室和通过第二流体管线与压力室流体连通的出口开口。 微量计量装置还包括用于检测置换器的相应位置的装置和连接到致动装置的控制装置和用于检测置换器的位置的装置，所述控制装置基于 检测置换器的位置，或者基于在至少一个以前的给料循环期间检测到的置换器位置，以便引起从出口开口排出限定体积的流体。 控制装置包括用于利用低边缘陡度的信号来控制致动装置的装置，以便使置换器从第一位置移动到预定的第二位置，置换器的第二位置限定压力室的体积更大， 第一名。 此外，控制装置包括用于利用具有高边缘陡度的信号来控制致动装置的装置，以便使置换器从第二位置移动到第一位置，以这种方式从出口开口排出限定体积的流体 。
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6.发明申请Device and Method for Producing a Mixture of Two Phases that are Insoluble in Each Other 审中-公开用于生产彼此不溶的两相混合物的装置和方法公开(公告)号：US20090197977A1
公开(公告)日：2009-08-06
申请号：US12089035
申请日：2006-09-19
申请人： Stefan Haeberle , Jens Ducree , Roland Zengerle
发明人： Stefan Haeberle , Jens Ducree , Roland Zengerle
CPC分类号： B01F5/0471 , B01F3/04446 , B01F3/0807 , B01F13/0062 , B01F15/0201 , B01F15/0233
摘要： A device for producing a mixture of two phases that are insoluble in each other comprises a first fluid channel and a second fluid channel which lead into a contact region. Also, a third fluid channel is provided which leads into the contact region. The device comprises an imparter configured to impart a rotation on the fluid channels, a first phase being centrifugally supplied to the contact region through the first fluid channel, and a second phase, insoluble in the first phase, being supplied to the contact region through the second fluid channel, compressive and/or shearing forces in the contact region which are centrifugally/hydrodynamically induced by the rotation causing drops to break away in one of the phases supplied in order to produce the mixture of the first and second phases.
摘要翻译： 用于生产彼此不溶的两相混合物的装置包括第一流体通道和引入接触区域的第二流体通道。 此外，提供了引入接触区域的第三流体通道。 该装置包括致动器，其构造成在流体通道上施加旋转，第一相通过第一流体通道离心地供给到接触区域，并且不溶于第一相的第二相被提供给接触区域 第二流体通道，接触区域中的压缩和/或剪切力，其通过旋转离心/流体动力学引起，导致在所提供的相之一中的液滴脱离以产生第一和第二相的混合物。
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公开(公告)号：US20060147313A1
公开(公告)日：2006-07-06
申请号：US11353681
申请日：2006-02-14
CPC分类号： B01L3/0268 , B01L2300/0838 , B01L2300/123 , B01L2400/0481 , Y10S239/12
摘要： A microdosing apparatus comprises a fluid conduit having a flexible tube with a first end for connecting to a fluid reservoir and a second end where an outlet opening is located. An actuating device with a displacer with adjustable hub is provided, by which the volume of a portion of the flexible hub can be changed to thereby dispense liquid as free flying droplets or as free flying jet at the outlet opening by moving the displacer between a first end position and a second end position, whereby the tube is partly compressed in the first or the second end position. In other words, a microdosing apparatus comprises fluid conduit having a portion along which a cross section of the fluid conduit is variable by an actuating device to effect a change of the volume of the fluid conduit. A ratio of a fluidic impedance between the position of the actuating device and the outlet opening to a fluidic impedance between a first end of the fluid conduit and the position of the actuating device is variable by changing the position of the actuating device, so that a dosing volume dispensed at the outlet opening is variable thereby by at least 10%.
摘要翻译： 微量给药装置包括具有柔性管的流体导管，其具有用于连接到流体储存器的第一端和位于出口开口的第二端。 提供具有可调节轮毂的置换器的致动装置，通过该致动装置可以改变柔性轮毂的一部分的体积，从而以自由飞行液滴的方式分配液体，或者在出口处通过移动置换器在第一 末端位置和第二端部位置，由此管部分地在第一或第二端部位置被压缩。 换句话说，微量滴定装置包括流体导管，其具有一部分，流体导管的横截面沿着该部分可由致动装置变化，以实现流体导管体积的变化。 驱动装置的位置与出口之间的流体阻抗与流体导管的第一端与致动装置的位置之间的流体阻抗的比值可通过改变致动装置的位置而变化，从而使 在出口处分配的给药量可变至少10％。
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公开(公告)号：US07748962B2
公开(公告)日：2010-07-06
申请号：US11624493
申请日：2007-01-18
申请人： Stefan Haeberle , Jens Ducrée , Roland Zengerle , Norbert Schmitt
发明人： Stefan Haeberle , Jens Ducrée , Roland Zengerle , Norbert Schmitt
CPC分类号： F04B43/04 , F04B43/0054 , F04B43/043
摘要： A fluid handling apparatus includes a body, which comprises a fluid handling structure, and a flexible membrane attached to the body and formed to interact with a fluid in the fluid handling structure, wherein the membrane comprises a first actuation component. A second actuation component is provided, wherein the first and the second actuation component are formed such that the same attract or repel each other in a first positional relationship, in order to actuate the flexible membrane. A driving means is provided to move the body relative to the second actuation component, in order to bring the first and the second actuation component into the first and out of the first positional relationship.
摘要翻译： 流体处理设备包括主体，其包括流体处理结构，以及附接到主体并形成为与流体处理结构中的流体相互作用的柔性膜，其中所述膜包括第一致动部件。 提供了第二致动部件，其中第一致动部件和第二致动部件形成为使得其以第一位置关系相互吸引或排斥，以便致动柔性膜。 提供驱动装置以使主体相对于第二致动部件移动，以便使第一和第二致动部件进入第一和第二位置关系。
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公开(公告)号：US09725758B2
公开(公告)日：2017-08-08
申请号：US13224645
申请日：2011-09-02
CPC分类号： C12Q1/6837 , B01J19/0046 , C12Q2535/00 , C12Q2535/122 , C12Q2561/113
摘要： A method of producing a replicate or derivative of an array of molecules, the array having a spatial arrangement of separate samples of molecules, includes creating, for each sample, at least one spatially limited effective area which is separate from the effective areas of the other samples, a surface, provided with a binding adapter or binding properties, of a carrier bordering on the effective areas. The molecules are amplified by means of amplifying agents in the effective areas for creating replicates or derivatives of the samples. The replicates or derivatives of the samples are bound to the carrier by means of the binding adapter or the binding properties, so that a spatial arrangement of the replicates or derivatives of the samples on the carrier corresponds to the spatial arrangement of the samples in the array. The carrier having the copies of the samples is removed from the array.
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10.发明申请Apparatus and Method for Determining the Volume Fractions of the Phases in a Suspension 失效用于确定悬浮液中相的体积分数的装置和方法公开(公告)号：US20080280365A1
公开(公告)日：2008-11-13
申请号：US12067226
申请日：2006-10-05
申请人： Markus Grumann , Jens Ducree , Roland Zengerle , Lutz Riegger
发明人： Markus Grumann , Jens Ducree , Roland Zengerle , Lutz Riegger
CPC分类号： B01L3/502753 , B01L3/502746 , B01L3/502769 , B01L2200/0621 , B01L2200/0642 , B01L2200/0684 , B01L2300/028 , B01L2300/0803 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/0409 , B01L2400/088 , Y10T436/11 , Y10T436/111666 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： An apparatus for determining the volume fractions of the phases in a suspension includes a body, a channel structure, which is formed in the body, and an inlet area and a blind channel, which is fluidically connected to and capable of being filled via the same. Furthermore, a drive for imparting the body with rotation, so that phase separation of the suspension in the blind channel takes place, is provided. The blind channel includes such a channel cross-section and/or such wetting properties that, when filling same via the inlet area, higher capillary forces act in a first cross-sectional area than in a second cross-sectional area, so that at first the first cross-sectional area fills in the direction from the inlet area toward the blind end of the blind channel and then the second cross-sectional area fills in the direction from the blind end toward the inlet area.
摘要翻译： 用于确定悬架中的相的体积分数的装置包括主体，形成在主体中的通道结构以及流体连接到并且能够经由其填充的入口区域和盲通道 。 此外，提供了用于赋予身体旋转的驱动器，使得发生盲通道中的悬架的相分离。 盲通道包括这样的通道横截面和/或这种润湿性质，当通过入口区域填充相同的这种润湿性质时，较高的毛细作用力处于比在第二横截面积中的第一横截面积中，使得首先 第一横截面积从入口区域朝向盲通道的盲端的方向填充，然后第二横截面积从盲端朝向入口区域的方向填充。
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