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公开(公告)号：US08043857B2
公开(公告)日：2011-10-25
申请号：US12650606
申请日：2009-12-31
IPC分类号： C12N15/74
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/523 , C07K14/33 , Y02A50/412
摘要： Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing such Mycobacterium strains.
摘要翻译： 提供具有增强的引起MHC-I类限制性CD8 + T细胞免疫应答能力的分枝杆菌菌株。 分枝杆菌菌株经遗传工程化以表达：在中性pH下具有活性的内分泌蛋白（例如Perfringolysin O），允许分枝杆菌从内体逃逸到细胞的细胞质中; 和目的抗原，如结核抗原。 本发明还提供含有这样的分枝杆菌菌株的疫苗制剂。
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公开(公告)号：US20100233213A1
公开(公告)日：2010-09-16
申请号：US12650606
申请日：2009-12-31
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/523 , C07K14/33 , Y02A50/412
摘要： Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing such Mycobacterium strains.
摘要翻译： 提供具有增强的引起MHC-I类限制性CD8 + T细胞免疫应答能力的分枝杆菌菌株。 分枝杆菌菌株经遗传工程化以表达：在中性pH下具有活性的内分泌蛋白（例如Perfringolysin O），允许分枝杆菌从内体逃逸到细胞的细胞质中; 和目的抗原，如结核抗原。 本发明还提供含有这样的分枝杆菌菌株的疫苗制剂。
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公开(公告)号：US07666656B2
公开(公告)日：2010-02-23
申请号：US11755936
申请日：2007-05-31
IPC分类号： C12N1/12
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/523 , C07K14/33 , Y02A50/412
摘要： Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomolytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing such Mycobacterium strains.
摘要翻译： 提供具有增强的引起MHC-I类限制性CD8 + T细胞免疫应答能力的分枝杆菌菌株。 分枝杆菌菌株被遗传工程化以表达：在中性pH下具有活性的内分解蛋白（例如Perfringolysin O），允许分枝杆菌从内体逃逸到细胞的细胞质中; 和目的抗原，如结核抗原。 本发明还提供含有这样的分枝杆菌菌株的疫苗制剂。
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4.发明授权Transformed bacterium lacking selectable marker and overexpression of antigens in mycobacteria 有权在分枝杆菌中缺乏选择性标记和抗原过表达的转化细菌公开(公告)号：US07625572B2
公开(公告)日：2009-12-01
申请号：US11288424
申请日：2005-11-29
CPC分类号： C12N15/74 , A61K39/04 , A61K2039/523
摘要： Recombinant Mycobacterium strains with improved vaccinal properties for use as vaccinating agents are provided. The parent strains of the recombinant Mycobacterium strains are selected for their potent immunogenicity. The Mycobacterium strains do not display antibiotic resistance, and do not exhibit horizontal transfer to gram-negative bacteria.
摘要翻译： 提供具有改进疫苗性质的重组分枝杆菌菌株用作疫苗接种剂。 选择重组分枝杆菌菌株的亲本菌株具有有效的免疫原性。 分枝杆菌菌株不显示抗生素抗性，并不表现出向革兰氏阴性细菌的水平转移。
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5.发明授权Electroporation of Mycobacterium and overexpression of antigens in mycobacteria 有权分枝杆菌的电穿孔和抗原在分枝杆菌中的过表达公开(公告)号：US07829104B2
公开(公告)日：2010-11-09
申请号：US11755768
申请日：2007-05-31
CPC分类号： A61K39/04 , A61K2039/523 , C12N15/74
摘要： Recombinant Mycobacterium strains with improved vaccinal properties for use as vaccinating agents are provided. The parent strains of the recombinant Mycobacterium strains are selected for their potent immunogenicity. The Mycobacterium strains do not display antibiotic resistance, and do not exhibit horizontal transfer to gram-negative bacteria.
摘要翻译： 提供具有改进疫苗性质的重组分枝杆菌菌株用作疫苗接种剂。 选择重组分枝杆菌菌株的亲本菌株具有有效的免疫原性。 分枝杆菌菌株不显示抗生素抗性，并不表现出向革兰氏阴性细菌的水平转移。
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6.发明申请Electroporation of Mycobacterium and Overexpression of Antigens in Mycobacteria 有权分枝杆菌的电穿孔和抗原在分枝杆菌中的过表达公开(公告)号：US20080286852A1
公开(公告)日：2008-11-20
申请号：US11755768
申请日：2007-05-31
IPC分类号： C12N1/21
CPC分类号： A61K39/04 , A61K2039/523 , C12N15/74
摘要： Recombinant Mycobacterium strains with improved vaccinal properties for use as vaccinating agents are provided. The parent strains of the recombinant Mycobacterium strains are selected for their potent immunogenicity. The Mycobacterium strains do not display antibiotic resistance, and do not exhibit horizontal transfer to gram-negative bacteria.
摘要翻译： 提供具有改进疫苗性质的重组分枝杆菌菌株用作疫苗接种剂。 选择重组分枝杆菌菌株的亲本菌株具有有效的免疫原性。 分枝杆菌菌株不显示抗生素抗性，并不表现出向革兰氏阴性细菌的水平转移。
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7.发明申请NOVEL RECOMBINANT BCG TUBERCULOSIS VACCINE DESIGNED TO ELICIT IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS IN ALL PHYSIOLOGICAL STAGES OF INFECTION AND DISEASE 有权新型重组BCG TUBERCULOSIS VACCINE设计用于在感染和疾病的所有生理阶段免疫应答MYCOBACTERIUM TUBCCOSOSIS公开(公告)号：US20090136534A1
公开(公告)日：2009-05-28
申请号：US11945680
申请日：2007-11-27
申请人： Avigdor Shafferman , Anat Zvi , Naomi Ariel , John Fulkerson , Ronggai Sun , Rosemary Chang , Jerald C. Sadoff
发明人： Avigdor Shafferman , Anat Zvi , Naomi Ariel , John Fulkerson , Ronggai Sun , Rosemary Chang , Jerald C. Sadoff
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/53 , C07K14/35
摘要： A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
摘要翻译： 提供了一种针对结核分枝杆菌（Mtb）的疫苗。 该疫苗包含一种重组的基于卡介苗（BCG）亚基的疫苗，其中一种或多种Mtb抗原和一种或多种Mtb复苏或再激活抗原过表达，其中至少部分DosR调节子被上调 。 疫苗在Mtb前后暴露于Mtb感染时可以防止活动性Mtb感染，从而预防由于潜伏的Mtb感染复发引起的疾病症状。
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8.发明申请公开(公告)号：US20100047286A1
公开(公告)日：2010-02-25
申请号：US11578124
申请日：2005-11-23
申请人： Ronggai Sun , David M. Hone , Jerald C. Sadoff
发明人： Ronggai Sun , David M. Hone , Jerald C. Sadoff
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/523 , C07K14/33 , Y02A50/412
摘要： Mycobacterium strains that have an enhanced ability to elicit a Histocompatibility-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell. The invention also provides vaccine preparations containing the Mycobacterium strains.
摘要翻译： 提供了具有增强的能够引发组织相容性I类限制性CD8 + T细胞免疫应答的分枝杆菌菌株。 分枝杆菌菌株进行遗传工程改造以表达在中性pH（例如Perfringolysin O）上有活性的内分泌蛋白，允许分枝杆菌从内体逃逸到细胞的细胞质中。 本发明还提供含有分枝杆菌菌株的疫苗制剂。
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9.发明授权Recombinant BCG tuberculosis vaccine designed to elicit immune responses to Mycobacterium tuberculosis in all physiological stages of infection and disease 有权设计用于在感染和疾病的所有生理阶段引起结核分枝杆菌的免疫应答的重组BCG结核病疫苗公开(公告)号：US07670609B2
公开(公告)日：2010-03-02
申请号：US11945680
申请日：2007-11-27
申请人： Avigdor Shafferman , Anat Zvi , Naomi Ariel , John Fulkerson , Ronggai Sun , Rosemary Chang , Jerald C. Sadoff
发明人： Avigdor Shafferman , Anat Zvi , Naomi Ariel , John Fulkerson , Ronggai Sun , Rosemary Chang , Jerald C. Sadoff
IPC分类号： A61K39/095
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/53 , C07K14/35
摘要： A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
摘要翻译： 提供了一种针对结核分枝杆菌（Mtb）的疫苗。 该疫苗包含一种重组的基于卡介苗（BCG）亚基的疫苗，其中一种或多种Mtb抗原和一种或多种Mtb复苏或再激活抗原过表达，其中至少部分DosR调节子被上调 。 疫苗在Mtb前后暴露于Mtb感染时可以防止活动性Mtb感染，从而防止由于潜在的Mtb感染复发引起的疾病症状。
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公开(公告)号：US08202723B2
公开(公告)日：2012-06-19
申请号：US13134190
申请日：2011-05-31
申请人： Menzo Jans Emco Havenga , Ronald Vogels , Jerald C. Sadoff , David Hone , Yasir Abdul Wahid Skeiky , Katarina Rado{hacek over (s)}evic
发明人： Menzo Jans Emco Havenga , Ronald Vogels , Jerald C. Sadoff , David Hone , Yasir Abdul Wahid Skeiky , Katarina Rado{hacek over (s)}evic
IPC分类号： C12N15/00 , C12N15/09 , C12N15/48 , C12N15/52 , C12N15/867
CPC分类号： A61K39/04 , A61K35/761 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/55544 , C07K14/35 , C07K2319/00 , C12N2710/10343
摘要： Described are vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding at least two antigens from one or more tuberculosis-causing bacilli. Also described is the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. Also described is the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.
摘要翻译： 描述了包含重组载体例如重组腺病毒的疫苗。 载体包含编码来自一种或多种结核分枝杆菌的至少两种抗原的异源核酸。 还描述了连接抗原的特异性蛋白酶识别位点的使用，通过该抗原，编码的抗原在切割时被分离。 在切割后，抗原以单独的方式有助于免疫应答。 重组载体可以包含编码切割接头并分离抗原的蛋白酶的核酸。 还描述了由重组载体编码的遗传佐剂的用途，其中这种遗传佐剂也可以通过可切割接头和特异性蛋白酶的存在来切割。
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