公开(公告)号：US07879903B2

公开(公告)日：2011-02-01

申请号：US12810660

申请日：2008-12-22

申请人： Rumiko Sakurai ,  Atsushi Yuzawa ,  Kenichi Sakai

发明人： Rumiko Sakurai ,  Atsushi Yuzawa ,  Kenichi Sakai

IPC分类号： C07D207/00 ,  A01N43/36

CPC分类号： C07D207/14 ,  C07B2200/07 ,  C07C51/412 ,  C07C59/64

摘要： An optically active 3-aminopyrrolidine (3AP) salt has a high optical purity which is useful as an intermediate in an industrial production method of an optically active 3AP, an efficient method for producing it, and an efficient industrial method for optical resolution of 3AP. Optical resolution of 3AP is efficiently carried out by reacting racemic 3AP with optically active 2-methoxyphenylacetic acid in the presence of a mineral acid such as hydrochloric acid in an aqueous solvent, followed by separation of the resulting diastereomer salt constituted by 1 mole of optically active 3AP and 2 moles of optically active 2-methoxyphenylacetic acid.

摘要翻译： 光学活性3-氨基吡咯烷（3AP）盐具有高光学纯度，可用作光学活性3AP的工业生产方法中的中间体，其有效的制备方法，以及3AP的光学拆分的有效工业方法。 在无机酸如盐酸的存在下，在水性溶剂中，通过使外消旋3AP与光学活性的2-甲氧基苯基乙酸反应，有效地进行3AP的光学拆分，然后分离由1摩尔光学活性的所得非对映异构体盐 3AP和2摩尔光学活性2-甲氧基苯基乙酸。

公开(公告)号：US07119211B2

公开(公告)日：2006-10-10

申请号：US10947333

申请日：2004-09-23

申请人： Kenichi Sakai ,  Rumiko Sakurai ,  Atsushi Yuzawa ,  Kaoru Hatahira

发明人： Kenichi Sakai ,  Rumiko Sakurai ,  Atsushi Yuzawa ,  Kaoru Hatahira

IPC分类号： C07D333/12 ,  C07D333/22

CPC分类号： C07D333/20

摘要： Disclosed is a process for commercial preparation of 3-(methylamino)-1-(2-thienyl)propan-1-ol (hereinafter abbreviated as “MMAA”) of the formula below: The process is carried out by the diastereomeric salt formation method using optically active mandelic acid or its derivatives, or an optically active tartaric acid derivative as the resolving agent. The product compound, diastereomeric satls, is useful as the intermediate for producing pharmaceuticals, such as duloxetine.

摘要翻译： 公开了用于商业制备下式的3-（甲基氨基）-1-（2-噻吩基）丙-1-醇（以下简称为“MMAA”）的方法：该方法通过非对映体盐形成法 使用光学活性扁桃酸或其衍生物，或光学活性酒石酸衍生物作为拆分剂。 产物化合物，非对映体ls可用作制备药物的中间体，例如度洛西汀。

公开(公告)号：US20100267966A1

公开(公告)日：2010-10-21

申请号：US12810660

申请日：2008-12-22

申请人： Rumiko Sakurai ,  Atsushi Yuzawa ,  Kenichi Sakai

发明人： Rumiko Sakurai ,  Atsushi Yuzawa ,  Kenichi Sakai

IPC分类号： C07D207/14

CPC分类号： C07D207/14 ,  C07B2200/07 ,  C07C51/412 ,  C07C59/64

摘要： An optically active 3-aminopyrrolidine (3AP) salt has a high optical purity which is useful as an intermediate in an industrial production method of an optically active 3AP, an efficient method for producing it, and an efficient industrial method for optical resolution of 3AP. Optical resolution of 3AP is efficiently carried out by reacting racemic 3AP with optically active 2-methoxyphenylacetic acid in the presence of a mineral acid such as hydrochloric acid in an aqueous solvent, followed by separation of the resulting diastereomer salt constituted by 1 mole of optically active 3AP and 2 moles of optically active 2-methoxyphenylacetic acid.

摘要翻译： 光学活性3-氨基吡咯烷（3AP）盐具有高光学纯度，可用作光学活性3AP的工业生产方法中的中间体，其有效的制备方法，以及3AP的光学拆分的有效工业方法。 在无机酸如盐酸的存在下，在水性溶剂中，通过使外消旋3AP与光学活性的2-甲氧基苯基乙酸反应，有效地进行3AP的光学拆分，然后分离由1摩尔光学活性的所得非对映异构体盐 3AP和2摩尔光学活性2-甲氧基苯基乙酸。

公开(公告)号：US20060063943A1

公开(公告)日：2006-03-23

申请号：US10947333

申请日：2004-09-23

申请人： Kenichi Sakai ,  Rumiko Sakurai ,  Atsushi Yuzawa ,  Kaoru Hatahira

发明人： Kenichi Sakai ,  Rumiko Sakurai ,  Atsushi Yuzawa ,  Kaoru Hatahira

IPC分类号： C07D333/12

CPC分类号： C07D333/20

摘要： Disclosed is a process for commercial preparation of 3-(methylamino)-1-(2-thienyl)propan-1-ol (hereinafter abbreviated as “MMAA”) of the formula below: The process is carried out by the diastereomeric salt formation method using optically active mandelic acid or its derivatives, or an optically active tartaric acid derivative as the resolving agent. The product compound, diastereomeric satls, is useful as the intermediate for producing pharmaceuticals, such as duloxetine.

摘要翻译： 公开了用于商业制备下式的3-（甲基氨基）-1-（2-噻吩基）丙-1-醇（以下简称为“MMAA”）的方法：

公开(公告)号：US4822967A

公开(公告)日：1989-04-18

申请号：US163618

申请日：1988-03-03

申请人： Naoki Kumagami ,  Yoshihiro Nakagawa ,  Atsushi Yuzawa ,  Kiichiro Hirose ,  Yukie Sato ,  Akihiro Shiosaka

发明人： Naoki Kumagami ,  Yoshihiro Nakagawa ,  Atsushi Yuzawa ,  Kiichiro Hirose ,  Yukie Sato ,  Akihiro Shiosaka

IPC分类号： A23L3/01 ,  H05B6/80 ,  H05B6/78

CPC分类号： H05B6/782 ,  A23L3/01 ,  Y10S99/14

摘要： The present invention provides a microwave heating sterilizer provided with a mechanism for turning over a retainer made from a material being permeable to microwave and which contains a "material to be sterilized" in a cavity irradiated with microwave therein supporting shafts extend from positions determined at point symmetry with respect to the center of the retainer on the opposite ends thereof, and turning-over parts each having a higher slide surface than the other part thereof on the midway of a guide which conveys the retainer and a turning-over groove on the midpoint thereof are provided.

公开(公告)号：US5262126A

公开(公告)日：1993-11-16

申请号：US848212

申请日：1992-03-10

申请人： Etsuo Shimamura ,  Sukenori Ito ,  Yuji Kawamura ,  Takuya Adachi ,  Atsushi Yuzawa ,  Masaaki Takada

发明人： Etsuo Shimamura ,  Sukenori Ito ,  Yuji Kawamura ,  Takuya Adachi ,  Atsushi Yuzawa ,  Masaaki Takada

IPC分类号： B65B55/10 ,  A61L2/00

CPC分类号： B65B55/103 ,  B65B55/10

摘要： A method for sterilizing a liquid packaging sleeve-like blank having two open ends and made of a laminated material including a paper layer, includes the steps of sterilizing the blanks by circulating a circulating unit holding a large number of blanks in a sterilizing tank which contains a sterilizing agent, to dip the blanks in the sterilizing agent, and removing the sterilizing agent by circulating another circulating unit holding the large number of blanks in a hot air drying tank in which hot air is blown, to dry the blanks.

摘要翻译： 一种用于对具有两个开口端并由包括纸层的层叠材料制成的液体包装套筒状坯料进行杀菌的方法包括以下步骤：将含有大量坯料的循环单元循环到消毒罐中，所述循环单元包含： 杀菌剂，将毛坯浸渍在灭菌剂中，通过将保存大量毛坯的另一个循环装置循环到热空气吹入的热风干燥箱中，除去灭菌剂，使毛坯干燥。

公开(公告)号：US4950772A

公开(公告)日：1990-08-21

申请号：US429425

申请日：1989-10-31

申请人： Hiroyuki Nohira ,  Shoko Takebayashi ,  Atsushi Yuzawa ,  Masami Yajima

发明人： Hiroyuki Nohira ,  Shoko Takebayashi ,  Atsushi Yuzawa ,  Masami Yajima

IPC分类号： C07D307/24

CPC分类号： C07D307/24

摘要： Disclosed is a method of racemization of optically active tetrahydrofuran-2-carboxylic acid. (+)-Tetrahydrofuran-2-carboxylic acid is useful as a side chain intermediate of the antibiotics of penem series, and is prepared by optical resolution of racemic compound. The remaining (+)-isomer should be racemized and reused as the material for further optical resolution. The racemization can be, in accordance with the present invention, carried out by heating the optically active tetrahydrofuran-2-carboxylic acid to a temperature of 100.degree. C. or higher in the presence of a strong base.

摘要翻译： 公开了光学活性四氢呋喃-2-羧酸外消旋化的方法。 （+） - 四氢呋喃-2-羧酸可用作penem系列抗生素的侧链中间体，并通过旋光拆分外消旋化合物制备。 其余（+） - 异构体应外消旋化并重新用作进一步光学拆分的材料。 根据本发明，外消旋化可以通过在强碱存在下将光学活性四氢呋喃-2-羧酸加热至100℃或更高的温度进行。

公开(公告)号：US5122340A

公开(公告)日：1992-06-16

申请号：US349839

申请日：1989-05-10

申请人： Etsuo Shimamura ,  Sukenori Ito ,  Yuji Kawamura ,  Takuya Adachi ,  Atsushi Yuzawa ,  Masaaki Takada

发明人： Etsuo Shimamura ,  Sukenori Ito ,  Yuji Kawamura ,  Takuya Adachi ,  Atsushi Yuzawa ,  Masaaki Takada

IPC分类号： B65B55/10

CPC分类号： B65B55/103 ,  B65B55/10

摘要： A method for sterilizing a liquid packaging sleeve-like blank having two open ends and made of a laminated material including a paper layer, includes the steps of sterilizing the blanks by circulating a circulating unit holding a large number of blanks in a sterilizing tank which contains a sterilizing agent, to dip the blanks in the sterilizing agent, and removing the sterilizing agent by circulating another circulating unit holding the large number of blanks in a hot air drying tank in which hot air is blowed, to dry the blanks.

公开(公告)号：US4963335A

公开(公告)日：1990-10-16

申请号：US347875

申请日：1989-05-05

申请人： Takuya Adachi ,  Sukenori Ito ,  Akihiro Shiosaka ,  Atsushi Yuzawa ,  Masaaki Takada ,  Kiichiro Okano ,  Masaru Kurihara ,  Hiromitsu Uchiyama

发明人： Takuya Adachi ,  Sukenori Ito ,  Akihiro Shiosaka ,  Atsushi Yuzawa ,  Masaaki Takada ,  Kiichiro Okano ,  Masaru Kurihara ,  Hiromitsu Uchiyama

IPC分类号： B65B55/10

CPC分类号： B65B55/10

摘要： A sterilizing apparatus for sterilizing a hollow prism-shaped carton open at both ends includes a sterilizing station, a drying station, and a solution-removing station located between the sterilizing station and the drying station. The solution-removing station has a solution-removing device which rotates intermittently in synchronism with carton conveyers. The solution-removing device includes a plurality of thin and long mandrels extending in a radial direction and spaced apart from each other at regular intervals. Each mandrel supports a carton and has a nozzle which supplies the aseptic air from an aseptic air source into the carton.