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15 条记录 (耗时 0.042 秒)

    Isoxazole, Dihydroisoxazole, And Oxadiazole Substituted Imidazo Ring Compounds And Method
    8.
    发明申请
    Isoxazole, Dihydroisoxazole, And Oxadiazole Substituted Imidazo Ring Compounds And Method 失效
    异恶唑，二氢异恶唑和恶二唑取代的咪唑环化合物及方法

    公开(公告)号：US20070287725A1

    公开(公告)日：2007-12-13

    申请号：US11570716

    申请日：2005-06-17

    申请人： William Miser ,  Joan Moseman ,  Tushar Kshirsagar ,  Philip Heppner

    发明人： William Miser ,  Joan Moseman ,  Tushar Kshirsagar ,  Philip Heppner

    IPC分类号： A61K31/437 ,  A61P31/12 ,  A61P35/00 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： Imidazo ring compounds, (e.g. imidazo[4,5-c]pyridine, imidazo[4,5-c]quinoline, 6,7,8,9-tetrahydro imidazo[4,5-c]quinoline, and imidazo[4,5-c]naphthyridine compounds) having an isoxazole, dihydroisoxazole, or oxadiazole substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

    摘要翻译： 咪唑环化合物（例如咪唑并[4,5-c]吡啶，咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉和咪唑并[ 在1位具有异恶唑，二氢异恶唑或恶二唑取代基的5-c]萘啶化合物，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成 并且公开了治疗包括病毒和肿瘤疾病在内的疾病。

    Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds
    10.
    发明申请
    Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds 失效
    哌嗪，[1,4]二氮杂环庚烷，[1,4]二氮杂环辛烷和[1,5]二氮辛烷稠合咪唑环化合物

    公开(公告)号：US20070167476A1

    公开(公告)日：2007-07-19

    申请号：US10596895

    申请日：2004-12-22

    申请人： Tushar Kshirsagar ,  George Griesgraber ,  Azim Celebi ,  Philip Heppner

    发明人： Tushar Kshirsagar ,  George Griesgraber ,  Azim Celebi ,  Philip Heppner

    IPC分类号： A61K31/4745 ,  C07D487/22

    CPC分类号： C07D471/14 ,  C07D471/04

    摘要： Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds (i.e., imidazoquinolines, tetrahydroimidazoquinolines, imidazonaphthyridines, tetrahydroimidazonaphthyridines, and imidazopyridines), pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

    摘要翻译： 哌嗪，[1,4]二氮杂环庚烷，[1,4]二氮杂环辛烷和[1,5]二氮辛烷稠合的咪唑环化合物（即咪唑并喹啉，四氢咪唑并喹啉，咪唑并噻嗪，四氢咪唑并萘啶和咪唑并吡啶） 公开了制备方法以及这些化合物作为免疫调节剂用于诱导或抑制动物细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病的方法。