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    Crystalline mixture solid containing maltitol and preparation therefor
    1.
    发明授权
    Crystalline mixture solid containing maltitol and preparation therefor 有权
    含有麦芽糖醇的结晶混合物固体及其制备方法

    公开(公告)号：US06863737B2

    公开(公告)日：2005-03-08

    申请号：US10048585

    申请日：2001-07-03

    申请人： Ryuzo Ueno ,  Akihiko Tabata ,  Junya Honda ,  Yojiro Furukawa

    发明人： Ryuzo Ueno ,  Akihiko Tabata ,  Junya Honda ,  Yojiro Furukawa

    IPC分类号： C07H3/04 ,  C07H15/04 ,  C13F1/02 ,  C07H1/00 ,  C07H1/06 ,  C08B30/00 ,  C13K5/00

    CPC分类号： C07H15/04 ,  C07H3/04

    摘要： A crystalline mixture solid containing maltitol having an oil absorptivity of 0.1 to 6.9 wt % and a bulk density of 0.60 to 0.75 g/cc when it is ground and classified to ensure that at least 70 wt % of the obtained particles should have a particle size of 16 to 50 mesh and a process for producing a crystalline mixture solid containing maltitol, comprising introducing air bubbles into a maltitol aqueous solution. According to this process, a crystalline mixture solid containing maltitol having high solubility and almost no moisture absorption is produced at a high work efficiency and a low cost in a short period of time.

    摘要翻译： 一种含有麦芽糖醇的结晶混合物固体，其研磨时的吸油率为0.1〜6.9重量％，体积密度为0.60〜0.75g / cc，并进行分级，以确保至少70重量％的所得颗粒具有粒径 16至50目的筛网和包含麦芽糖醇的结晶混合物固体的方法，包括将气泡引入到麦芽糖醇水溶液中。 根据该方法，以高工作效率和短时间内的低成本生产含有高溶解度且几乎不吸湿的麦芽糖醇的结晶混合物固体。

    Crystalline mixture solid composition and process for preparation thereof
    2.
    发明授权
    Crystalline mixture solid composition and process for preparation thereof 失效
    结晶混合物固体组合物及其制备方法

    公开(公告)号：US06746541B2

    公开(公告)日：2004-06-08

    申请号：US09958666

    申请日：2001-10-12

    申请人： Ryuzo Ueno ,  Akihiko Tabata ,  Junya Honda ,  Yojiro Furukawa ,  Sho Arai

    发明人： Ryuzo Ueno ,  Akihiko Tabata ,  Junya Honda ,  Yojiro Furukawa ,  Sho Arai

    IPC分类号： C13F300

    CPC分类号： C07H1/08 ,  A23L27/34 ,  C40B40/00

    摘要： A crystalline mixture solid composition which has almost no hygroscopicity, is easy to handle and dissolve and hardly worn by abrasion, and comprises &agr;-D-glucopyranosyl-1,1-mannitol and &agr;-D-glucopyranosyl-1,6-sorbitol and may further comprise &agr;-D-glucopyranosyl-1,1-sorbitol in a certain case is obtained in an extremely short period of time by a power-saving and labor-saving process with a small-scale apparatus. A composition which comprises 20 to 75 wt % of &agr;-D-glucopyranosyl-1,1-mannitol, 23 to 70 wt % of &agr;-D-glucopyranosyl-1,6-sorbitol and 2 to 25 wt % of &agr;-D-glucopyranosyl-1,1-sorbitol and is in a crystalline mixture solid state or has a specific surface area of 0.07 to 0.1 m2/g, and a composition which comprises 30 to 75 wt % of &agr;-D-glucopyranosyl-l,1-mannitol, 25 to 70 wt % of &agr;-D-glucopyranosyl-1,6-sorbitol and has a specific surface area of 0.07 to 0.1 m2/g. The above compositions are produced by a process comprising supplying a raw material, which is obtained by optionally removing trehalulose from a mixture containing isomaltulose and trehalulose produced from cane sugar through an isomerization reaction and hydrogenating into a kneader having a thin and long cooling zone together with seed crystals and discharging the obtained composition from an outlet continuously.

    摘要翻译： 具有几乎没有吸湿性的结晶混合物固体组合物易于处理和溶解并且几乎不被磨损磨损，并且包括α-D-吡喃葡萄糖基-1,1-甘露醇和α-D-吡喃葡萄糖基-1,6-山梨糖醇，并且还可以包含α 通过小型装置的省电省力的方法，在极短的时间内可以获得一定的D-吡喃葡萄糖基-1,1-山梨醇.1。一种组合物，其含有20〜75重量％ α-D-吡喃葡萄糖基-1,1-甘露醇，23〜70重量％的α-D-吡喃葡萄糖基-1,6-山梨醇和2〜25重量％的α-D-吡喃葡萄糖基-1,1-山梨醇， 结晶混合物固态或比表面积为0.07〜0.1m 2 / g，组成为30〜75重量％的α-D-吡喃葡萄糖基-1,1-甘露糖醇，25〜70重量％ 的α-D-吡喃葡萄糖基-1,6-山梨糖醇，其比表面积为0.07〜0.1m 2 / g。上述组合物通过包括供给原料的方法制备， 通过任选地通过异构化反应从蔗糖产生的异麦芽酮糖和海藻糖醇的混合物中任选除去海藻糖糖，并将其与晶种一起氢化成具有薄而长的冷却区的捏合机，并连续从出口排出所得组合物。

    Maltitol crystals containing crystal of saccharide except maltitol and method for production thereof
    3.
    发明申请
    Maltitol crystals containing crystal of saccharide except maltitol and method for production thereof 审中-公开
    含麦芽糖醇以外的糖的结晶的麦芽糖醇晶体及其制造方法

    公开(公告)号：US20050118316A1

    公开(公告)日：2005-06-02

    申请号：US10451778

    申请日：2002-10-17

    申请人： Ryuzo Ueno ,  Akihiko Tabata ,  Junya Honda ,  Yojiro Furukawa ,  Yoshiaki Kuriyama

    发明人： Ryuzo Ueno ,  Akihiko Tabata ,  Junya Honda ,  Yojiro Furukawa ,  Yoshiaki Kuriyama

    IPC分类号： C07H15/04 ,  A23L1/236

    CPC分类号： C07H15/04

    摘要： Maltitol crystals containing sugar crystals other than maltitol which have excellent solubility, almost no hygroscopicity, do not become bulky when they are stored or transported because they have a large bulk density, a small difference between packed bulk density and loose bulk density thereof and excellent flowability. The maltitol crystals containing sugar crystals other than maltitol have a loose bulk density of particles having a particle size of 20 to 50 mesh after grinding and classification of more than 0.750 g/cd and 0.850 g/cc or less.

    摘要翻译： 含有麦芽糖醇以外的糖晶体的麦芽糖醇晶体具有优异的溶解性，几乎没有吸湿性，由于它们具有大的堆积密度，堆积密度和其松散堆积密度之间的小差异以及优异的流动性，因此在储存或运输时不会变得笨重 。 含麦芽糖醇以外的糖晶体的麦芽糖醇晶体在研磨后的粒径为20〜50目的粒子的松散体积密度大于0.750g / cm 2，分级为0.850g / cc以下。

    Crystalline mixture solid composition and preparation thereof
    4.
    发明授权
    Crystalline mixture solid composition and preparation thereof 失效
    结晶混合物固体组合物及其制备

    公开(公告)号：US06755914B2

    公开(公告)日：2004-06-29

    申请号：US10030981

    申请日：2002-01-16

    申请人： Ryuzo Ueno ,  Akihiko Tabata ,  Junya Honda ,  Yojiro Furukawa ,  Sho Arai

    发明人： Ryuzo Ueno ,  Akihiko Tabata ,  Junya Honda ,  Yojiro Furukawa ,  Sho Arai

    IPC分类号： C08B3000

    CPC分类号： C07H15/04 ,  A23L27/34

    摘要： A crystalline mixture solid composition comprising &agr;-D-glucopyranosyl-1,1-mannitol (GPM), &agr;-D-glucopyranosyl-1,6-sorbitol (GPS-6) and a small amount of &agr;-D-glucopyranosyl-1,1-sorbitol (GPS-1) and a production process therefor. The above crystalline mixture solid composition is produced by mixing a hydrophilic solvent with a solid composition or aqueous solution comprising 50 to 80 wt % of GPM, 1 to 50 wt % of GPS-6 and 0.01 to 20 wt % of GPS-1, separating solid matter from a liquid, and removing water and the solvent from the solid matter and can be obtained as a thin scale crystal.

    摘要翻译： 包含α-D-吡喃葡萄糖基-1,1-甘露醇（GPM），α-D-吡喃葡萄糖基-1,6-山梨糖醇（GPS-6）和少量α-D-吡喃葡萄糖基-1的结晶混合物固体组合物， 1-山梨糖醇（GPS-1）及其制备方法。 上述结晶混合物固体组合物通过将亲水性溶剂与固体组合物或包含50-80重量％GPM，1至50重量％的GPS-6和0.01至20重量％的GPS-1的水溶液混合来制备，分离 来自液体的固体物质，并且从固体物质中除去水和溶剂，并且可以作为薄标尺晶体获得。

    Process for producing crystalline maltitol
    5.
    发明申请
    Process for producing crystalline maltitol 审中-公开
    生产结晶麦芽糖醇的方法

    公开(公告)号：US20050220959A1

    公开(公告)日：2005-10-06

    申请号：US10517451

    申请日：2003-06-16

    申请人： Ryuzo Ueno ,  Junya Honda ,  Yojiro Furukawa

    发明人： Ryuzo Ueno ,  Junya Honda ,  Yojiro Furukawa

    IPC分类号： A23L1/236 ,  C07H1/00 ,  C07H15/04 ,  C13B30/02

    CPC分类号： C07H15/04 ,  A23L27/34 ,  A23V2002/00 ,  C07H1/00 ,  C13B30/02 ,  A23V2250/6416

    摘要： There is provided methods for producing crystalline maltitol without using seed crystals, with good workability, at low costs, and with efficiency in a short time. One of the methods comprises the steps of feeding a first maltitol aqueous solution to a kneader so as to knead and cool it, then feeding a second maltitol aqueous solution having a high solid content in place of the first maltitol aqueous solution and further kneading and cooling the resulting mixture so as to produce a plastic mass, cooling the plastic mass so as to solidify it, and pulverizing the solidified mass. The other method comprises the steps of feeding a maltitol aqueous solution to a kneader so as to knead and cool it, then adding water and further kneading and cooling the mixture so as to produce a plastic mass, cooling the plastic mass so as to solidify it, and pulverizing the solidified mass.

    摘要翻译： 提供了不使用晶种生产结晶麦芽糖醇的方法，具有良好的可加工性，低成本和短时间的效率。 其中一种方法包括以下步骤：将第一麦芽糖醇水溶液加入到捏和机中进行混炼和冷却，然后加入固体含量高的第二麦芽糖醇水溶液代替第一麦芽糖醇水溶液，并进一步混炼和冷却 得到的混合物，以产生塑料块，冷却塑料块使其固化，并粉碎固化的物料。 另一种方法是将麦芽糖醇水溶液进料到捏合机中进行混合和冷却，然后加水并进一步混炼和冷却混合物以产生塑料块，冷却塑料块使其固化 ，并粉碎固化物。

    Method for inhibiting infection of human T-cells
    8.
    发明授权
    Method for inhibiting infection of human T-cells 失效
    抑制人类T细胞感染的方法

    公开(公告)号：US4840941A

    公开(公告)日：1989-06-20

    申请号：US144131

    申请日：1988-01-15

    申请人： Ryuzo Ueno ,  Ryuji Ueno ,  Sachiko Kuno ,  Akihiko Tabata

    发明人： Ryuzo Ueno ,  Ryuji Ueno ,  Sachiko Kuno ,  Akihiko Tabata

    IPC分类号： A61K31/715 ,  C07H11/00

    CPC分类号： C07H11/00 ,  A61K31/715

    摘要： Method of treatment of diseases caused by retroviruses which comprises administering therapeutically effective amount of a natural or synthetic oligo- or polysaccharide having at least one S-oxoacid group attached to the saccharic carbon atom through a linking group of lower molecular weight or a pharmaceutically acceptable salt thereof to a subject in need of such treatment.

    摘要翻译： 治疗由逆转录病毒引起的疾病的方法，该方法包括给予治疗有效量的具有至少一个S-糖酸基团的天然或合成的寡糖或多糖，其通过低分子量的连接基团或药学上可接受的盐连接到糖质碳原子上 对于需要这种治疗的对象。