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公开(公告)号：US10195356B2
公开(公告)日：2019-02-05
申请号：US14905382
申请日：2014-07-17
申请人： Sanofi
发明人： Tom Oakley , Karl Hewson , Stuart Milne , Mark Pawulski
摘要： A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device includes a cartridge containing liquid, a dosing element, which rotates during dose selecting, a last dose nut coupled to the dosing element during dose selecting such that rotation of the dosing element causes an axial movement of the last dose nut, and a stop element, which is provided on the dosing element and which blocks further movement of the last dose nut, if a dose is selected corresponding to the amount of liquid left in the cartridge. The device further includes a last dose sleeve rotationally coupled to the dosing element during dose selecting and rotationally decoupled from the dosing element during dose dispensing.
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公开(公告)号：US09987429B2
公开(公告)日：2018-06-05
申请号：US14904720
申请日：2014-07-17
申请人： Sanofi
发明人： Tom Oakley , Stuart Milne
CPC分类号： A61M5/31 , A61M5/31553 , A61M2005/2411 , A61M2005/3126 , A61M2205/583
摘要： A display assembly is proposed, comprising: a body (4) defining a window (17) having an axial extension, an indication member (2) for providing information to be displayed in the window (17), wherein the indication member (2) is movable relative to the body (4) for changing the information displayed in the window (17), a selection member (3), wherein the selection member (3) defines a masking section (45) and a non-masking section (46), the selection member (3) is rotatable around a rotation axis (x) with respect to the body (4) and with respect to the indication member (2), the non-masking section (46) and the masking section (45) partially overlap with the window (17) to define a displayed section (52) of the indication member (2), and wherein the selection member (3) and the indication member (2) are coupled such that the displayed section (52) of the indication member (2) is axially displaced within the window (17).
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公开(公告)号：US10912888B2
公开(公告)日：2021-02-09
申请号：US14905230
申请日：2014-07-17
申请人： Sanofi
发明人： Tom Oakley , Stuart Milne
摘要： The driving configuration for a drug delivery device comprises an energy storing member (2) providing a force suitable for driving a bung (1) arranged in a container (3), the bung being movable relative to the container. The energy storing member (2) is loaded by an alteration of its mechanical state with respect to a mounting element (5), which is relocatable in such a manner that a force provided by the energy storing member when it is loaded is reduced by a relocation of the mounting element.
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公开(公告)号：US10155089B2
公开(公告)日：2018-12-18
申请号：US14905393
申请日：2014-07-17
申请人： Sanofi
发明人： Tom Oakley , Karl Hewson , Stuart Milne , Mark Pawulski
摘要： A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a housing, a cartridge holder for receiving a cartridge, a lead screw and means for driving the lead screw during dose dispensing. The lead screw is coupled to the cartridge holder such that the cartridge holder is axially displaced with respect to the housing and the lead screw during dose dispensing.
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公开(公告)号：US20160144128A1
公开(公告)日：2016-05-26
申请号：US14905129
申请日：2014-07-17
申请人： SANOFI
发明人： Tom Oakley , Matt Schumann
IPC分类号： A61M5/315
CPC分类号： A61M5/31568 , A61M5/20 , A61M5/2033 , A61M5/3155 , A61M5/31583 , A61M2005/3126
摘要： The present disclosure relates to a counting mechanism (2) for a drug delivery device (1) comprising a first counting member (4) arranged for displaying a counted number and being biased to move in a first rotational direction and a connecting member (5) having a dose setting position and a dose dispensing position, wherein, in the dose setting position, the connecting member (5) impedes a rotation of the first counting member (4) in the first rotational direction, and wherein, in the dose dispensing position, the connecting member (5) permits the first counting member (4) to rotate in the first rotational direction.
摘要翻译： 本公开涉及一种用于药物输送装置（1）的计数机构（2），包括：第一计数构件（4），被布置成用于显示计数并被偏置以沿第一旋转方向移动;以及连接构件（5） 具有剂量设定位置和剂量分配位置，其中，在所述剂量设定位置，所述连接部件（5）阻止所述第一计数部件（4）沿所述第一旋转方向旋转，并且其中，在所述剂量分配位置 ，连接构件（5）允许第一计数构件（4）沿第一旋转方向旋转。
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公开(公告)号：US10279118B2
公开(公告)日：2019-05-07
申请号：US14905078
申请日：2014-07-17
申请人： Sanofi
发明人： Tom Oakley , Matt Schumann , Mark Pawulski
摘要： A drive mechanism (11) for a delivery device comprising a drive member (17) for driving a piston rod (13); a moveable dose setting member (19, 35) being disengaged from the drive member (17) in a dose setting state and being moveable in a drive direction in a dose delivery state, wherein the dose setting member (19, 35) engages with the drive member (17) in the dose delivery state in such a manner that the movement of the dose setting member (19, 35) in the drive direction is transferred to the drive member (17); and a spring member (21) being coupled to the dose setting member (19, 35) in such a manner that the movement of the dose setting member (19, 35) in a setting direction loads the spring member (21) in the dose setting state, the spring force of the loaded spring member (21) driving the dose setting member (19, 35) in the drive direction in the dose delivery state.
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公开(公告)号：US10137249B2
公开(公告)日：2018-11-27
申请号：US14904746
申请日：2014-07-17
申请人： Sanofi
发明人： Tom Oakley , Matt Schumann , Stuart Milne
摘要： The priming configuration comprises a piston rod (1), a bung (2), which is provided to be driven by the piston rod, and a movable element (5), which is engaged with the piston rod. The movable element is arranged to be movable in a predefined direction (10) with respect to the piston rod by a user of the drug delivery device. A movement of the movable element in the predefined direction advances the piston rod in a further direction (11), providing a priming of the drug delivery device before use. The predefined direction may especially be transverse to the further direction, and the further direction may especially be directed from the piston rod towards the bung (2). A gap (12) or clearance between the piston rod (1) and the bung (2) can thus be removed, and the stiction of the bung (2) to the cartridge (3) can be reduced.
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公开(公告)号：US09987433B2
公开(公告)日：2018-06-05
申请号：US14905446
申请日：2014-07-17
申请人： Sanofi
发明人： Tom Oakley , Matt Schumann , Stuart Milne
CPC分类号： A61M5/31541 , A61M5/20 , A61M5/3146 , A61M5/31501 , A61M5/31535 , A61M5/31543 , A61M5/31553 , A61M5/31561 , A61M5/3157 , A61M5/31573 , A61M5/31583 , A61M2005/3126 , A61M2205/581 , A61M2205/586
摘要： An assembly for a drug delivery device (200) is presented which comprises a housing (24) having a proximal end (25) and a distal end (26), a cartridge, a plunger (19) which is movably retained in the cartridge (14) and a piston rod (6). The assembly further comprises a rod displacement feature (33). The assembly is configured such that, in an initial state of the assembly, the piston rod (6) and the rod displacement feature (33) are arranged such that movement of the rod displacement feature (33) from the first position to the second position is transferred to the piston rod (6) such that the piston rod (6) is moved with respect to the cartridge (14) and the assembly is switched from the initial state to a primed state. In the primed state, movement of the rod displacement feature (33) from the first position to the second position is not transferred to the piston rod (6).
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公开(公告)号：US20160158454A1
公开(公告)日：2016-06-09
申请号：US14904739
申请日：2014-07-17
申请人： SANOFI
发明人： Tom Oakley , Karl Hewson , Stuart Milne , Mark Pawulski
摘要： The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a cartridge (170) containing a medicament and a last dose protection mechanism for preventing the selection of a dose, which exceeds the amount of medicament left in a cartridge (170). This last dose protection mechanism comprises a first member (60), which is rotatable in a first direction during dose FIG. 2 selecting and in the opposite direction during dose dispensing, a second member (50) coupled to the first member (60) and to the housing (10) such that the second member is moved relative to the first member (60) and to the housing (10) upon rotation of the first member (60) and a third member (100) which is moved relative to the first and second member (50, 60) during dose dispensing. Abutment of the second and third member (50, 100) prevents increasing the selected dose.
摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置。 该装置包括壳体（10），容纳药物的药筒（170）和用于防止剂量的最后剂量保护机构，其超过药盒（170）中留下的药物量。 该最后剂量保护机构包括第一构件（60），其可以在剂量期间沿第一方向旋转。 2在剂量分配期间选择和相反方向，联接到第一构件（60）和壳体（10）的第二构件（50），使得第二构件相对于第一构件（60）移动到第二构件 第一构件（60）旋转时的壳体（10）和在剂量分配期间相对于第一和第二构件（50,60）移动的第三构件（100）。 第二和第三成员（50,100）的基台防止增加所选择的剂量。
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公开(公告)号：US20160158453A1
公开(公告)日：2016-06-09
申请号：US14905147
申请日：2014-07-17
申请人： SANOFI
发明人： Tom Oakley , Matt Schumann , Mark Pawulski
IPC分类号： A61M5/315
CPC分类号： A61M5/31526 , A61M5/20 , A61M5/31535 , A61M5/31536 , A61M5/31551 , A61M5/31553 , A61M5/31558 , A61M5/31563 , A61M5/31578 , A61M5/31583 , A61M2005/3126
摘要： A drive mechanism (11) for a delivery device comprising —a drive member (17) for driving a piston rod (13); —a moveable dose setting member (19, 35) being decoupled from the drive member (17) in a dose setting state; the dose setting member (19, 35) being moveable in a drive direction in a dose delivery state, wherein the movement of the dose setting member (19, 35) is transferred to the drive member (17); and —a dose control means (49) being coupled to the dose setting member (19, 35) by a rack-and-pinion means (51, 67) in such a manner that the movement of the dose setting member (19, 35) is transferred to a movement of the dose control means (49), wherein the movement of the dose setting member (19, 35) is stopped when the dose control means (49) reaches an end position.
摘要翻译： 一种用于输送装置的驱动机构（11），包括：用于驱动活塞杆（13）的驱动构件（17）。 - 可动剂量设定构件（19,35）在剂量设定状态下与所述驱动构件（17）分离; 所述剂量设定部件（19,35）能够在剂量输送状态下沿驱动方向移动，其中所述剂量设定部件（19,35）的移动被传递到所述驱动部件（17）。 和 - 剂量控制装置（49），其通过齿条和小齿轮装置（51,67）以剂量设定构件（19,35）的移动方式联接到剂量设定构件（19,35） ）被转移到剂量控制装置（49）的移动，其中当剂量控制装置（49）到达结束位置时，剂量设定构件（19,35）的移动停止。
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