公开(公告)号：US20240277828A1

公开(公告)日：2024-08-22

申请号：US18653422

申请日：2024-05-02

申请人： SANOFI PASTEUR INC

发明人： Timothy ALEFANTIS ,  Mario BARRO ,  Anthony BYERS ,  Guadalupe CORTES-GARCIA ,  Philippe-Alexandre GILBERT ,  Harold KLEANTHOUS ,  Armaghan NAIK ,  Konstantin PUGACHEV ,  Saranya SRIDHAR ,  Thorsten VOGEL ,  William WARREN

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P37/04

CPC分类号： A61K39/145 ,  A61P37/04 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/70

摘要： Disclosed herein are multivalent vaccine or immunogenic compositions comprising one or more recombinant influenza virus hemagglutinin (HA), one or more recombinant influenza virus neuraminidase (NA), and an optional adjuvant. Also disclosed are methods of using the vaccine or immunogenic composition.

公开(公告)号：US20240335525A1

公开(公告)日：2024-10-10

申请号：US18682372

申请日：2022-08-10

申请人： SANOFI PASTEUR INC.

发明人： Mario BARRO ,  Yvonne CHAN ,  Guadalupe CORTES-GARCIA ,  Raul GOMILA ,  Liqun HAN ,  Justin KLEKOTA ,  Fuqin MA ,  Satyajit RAY ,  Svetlana STEGALKINA ,  Tod STRUGNELL ,  Irina USTYUGOVA ,  Thorsten VOGEL ,  Jianxin ZHANG

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005 ,  C07K14/705 ,  C12N9/24

CPC分类号： A61K39/145 ,  A61P37/04 ,  C07K14/005 ,  C07K14/70596 ,  C12N9/2402 ,  C12Y302/01018 ,  A61K2039/645 ,  C07K2319/02 ,  C12N2760/16134

摘要： Provided are modified influenza virus subtype 2 neuraminidase molecules lacking all or substantially all of the stalk region that form active, soluble tetrameric neuraminidase when expressed in host cells and vaccine compositions comprising the tetrameric neuraminidase or a nucleic acid encoding the modified monomeric influenza virus subtype 2 neuraminidase molecules that forms tetrameric NA when expressed in a cell. Also provided are methods of using the vaccine compositions to vaccinate or immunize a subject against influenza virus.

公开(公告)号：US20240269258A1

公开(公告)日：2024-08-15

申请号：US18627824

申请日：2024-04-05

申请人： SANOFI PASTEUR INC.

发明人： Timothy ALEFANTIS ,  Mario BARRO ,  Anthony BYERS ,  Philip DAVIDSON ,  Maryann GIEL-MOLONEY ,  Philippe-Alexandre GILBERT ,  Harold KLEANTHOUS ,  Armaghan NAIK ,  Konstantin PUGACHEV ,  Saranya SRIDHAR ,  William WARREN ,  Konstantin ZELDOVICH

IPC分类号： A61K39/145 ,  A61K9/00 ,  A61K39/00 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61K9/0019 ,  C07K14/005 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16322 ,  C12N2760/16334

摘要： Disclosed are multivalent vaccine or immunogenic compositions comprising influenza virus hemagglutinin (HA) from standard of care influenza virus strains, or ribonucleic acid molecules encoding the same; and one or more influenza virus HA identified or designed by machine learning, or one or more ribonucleic acid molecules that encode the influenza virus HA identified or designed by machine learning. Also disclosed are methods of using the vaccine or immunogenic compositions.